Discovery of diagonositc and therapeutic biomarker by circulating tumor endothelial cells in metastatic renal cell carcinoma
| Project/Area Number |
23592320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHINOHARA Nobuo 北海道大学, 医学(系)研究科(研究院), 准教授 (90250422)
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| Co-Investigator(Kenkyū-buntansha) |
HIDA Kyoko 北海道大学, 歯学研究科, 特任准教授 (40399952)
HIDA Yasuhiro 北海道大学, 大学病院, 講師 (30399919)
NONOMURA Katsuya 北海道大学, 大学院医学研究科, 特任教 授 (60113750)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 腎癌 / バイオマーカー / 腫瘍血管内皮細胞 / 腫瘍血管内皮 / 循環血管内皮 / 転移 / 腎臓がん / 末梢循環主要血管内皮細胞 / 転移性腎癌 / 診断・治療バイオマーカー |
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| Research Abstract |
We identified several markers (PTGIR, Biglycan, LOX, CXCR7 etc. ) highly expressed in mouse tumor endothelial cell (TEC) by real-time PCR of circulating endothelial cell (CEC) in metastatic renal cell carcinoma(RCC). We isolated human TEC from human RCC tissues and human normal endothelial cell (NEC) from normal kidney tissues of six patients. PTGIR, Biglycan, LOX and CXCR7 expression levels were significantly higher in human TEC than in human NEC for all paired cases. These results suggested that CEC might be a useful biomarker of RCC.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Chromophobe renal cell carcinoma, oncocytic variant : A proposal of a new variant and a critical diagnostic pitfall in diagnosing renal oncocytic tumors2013
Author(s)
Kuroda N, Tanaka A, Yamaguchi T, Kasahara K, Naruse K, Yamada Y, Chikai-Kubota K, Shinohara N, Nagashima Y, Mikami S, Oya M, Hamashima T, Michal M, Hes O
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Journal Title
Med. Mol. Morphol
Volume: 46(1)
Pages: 49-55
Related Report
Peer Reviewed
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[Journal Article] The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma2013
Author(s)
Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, Hida K
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Journal Title
Pathol. Int
Volume: 63(1)
Pages: 37-44
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safey of axitinib versus sorafenib in metastatic renal cell carcinoma : subgroup analysis of Japanese patients from a randomized phase 3 AXIS trial2013
Author(s)
Ueda T, Uemura H, Tomita Y, Tsukamoto T, Kanayama H, Shinohara N, Tarazl J, Chen C, Kim S, Ozono S, Naito S, Akaza H
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Journal Title
Jpn. J. Clin. Oncol
Volume: 43(6)
Pages: 616-628
Related Report
Peer Reviewed
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[Journal Article] Lysyl oxidase secreted by tumor endothelial cells promotes angiogenesis and metastasis2013
Author(s)
Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujita M, Shinohara N, Nonomura K, Shindoh M, Hida K
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Journal Title
Br J Cancer
Volume: 109(8)
Pages: 2237-2247
Related Report
Peer Reviewed
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[Journal Article] The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma2013
Author(s)
Akiyama K., Ohga N., Maishi N., Hida Y., Kitayama K., Kawamoto T., Osawa T., Suzuki Y., Shinohara N., Nonomura K., Shindoh M., Hida K.
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Journal Title
Pathol. Int.
Volume: 63(1)
Issue: 1
Pages: 37-44
DOI
Related Report
Peer Reviewed
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