Treatment of metastatic carcinoma using non-viable bacterial BCG formulation

• Project/Area Number: 23592323
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: University of Tsukuba
• Principal Investigator: KAWAI Kouji 筑波大学, 医学医療系, 講師 (90272195)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI Jun 筑波大学, 医学医療系, 准教授 (10550246)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 泌尿器科 / ビーシージー / 癌免疫 / リポソーム / ミコール酸 / 発光タンパク質 / BCG-CWS / cell wall skeleton / BCG / 膀胱癌

Research Abstract

Mycobacteriuma bovis bacillus Calmette-Guerin (BCG) intravesical therapy is a cancer immunotherapy which has been established. However, it is not applicable to metastatic lesion because of side effects caused by live bacteria. We have developed a small-diameter particles of liposome BCG-CWS (cell wall skeleton) with a view to industrialization.

Research Products

• [Journal Article] Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: current understanding and perspectives on engineered BCG vaccine. (2013)
  • Author(s): Kawai K, Miyazaki J, Joraku A, Nishiyama H, Akaza H.
  • Journal Title: Cancer Sci. Volume: 104 Issue: 1 Pages: 22-27
  • DOI: 10.1111/cas.12075
  • Peer Reviewed
• [Presentation] BCG-CWS搭載ナノ粒子を基盤とした膀胱癌治療剤の開発 (2013)
  • Author(s): 中村孝司、吹上雅文、中谷彰洋、矢野郁也、宮崎淳、西山博之、赤座英之、伊藤俊宏、細川裕之、中山俊憲、原島秀吉
  • Organizer: 第6回BCG注入療法研究会
  • Place of Presentation: 如水会館
  • Year and Date: 2013-11-22
• [Presentation] BCGミコール酸(MA)搭載リポソーム製剤投与によるBBN発癌ラットの治療効果について (2011)
  • Author(s): 宮崎淳、河合弘二、矢野郁也、西山博之、中村孝司、原島秀吉、赤座英之
  • Organizer: 第4回BCG注入療法研究会
  • Place of Presentation: 東京
• [Patent(Industrial Property Rights)] 特許 (2012)
  • Inventor(s): 宮崎淳
  • Industrial Property Rights Holder: 宮崎淳
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-188129
  • Filing Date: 2012-08-28