Development of bladder cancer early diagnosis and treatment method using the CXCR4-beta arrestin2-ERK pathway
Project/Area Number |
23592330
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Jun 筑波大学, 医学医療系, 准教授 (10550246)
OIKAWA Takehiro 筑波大学, 医学医療系, 講師 (00361345)
SUETOMI Takahiro 筑波大学, 医学医療系, 講師 (10574650)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | CXCR4 / ARRB2 / TXNIP / bladder / carcinogenesis / 尿路上皮癌 / βarrestin2 / 膀胱癌早期診断治療法 / BBN / EMT / E cadherin |
Research Abstract |
The result of gene and protein expression of CXCR4-ERK pathway and TXNIP-ARRB2 pathway in mouse bladder cancer model and bladder cancer cell lines. We indicate that TXNIP negatively regulates bladder carcinogenesis by attenuating SDF-1-CXCR4-induced ERK activation. This signal transduction pathway can be a potent target in preventing or treating bladder cancer.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The Transcription Factor Sp3 Regulates the Expression of a Metastasis-Related Marker of Sarcoma, Actin Filament-Associated Protein 1-Like 1 (AFAP1L1).2013
Author(s)
Kajita Y, Kato T Jr, Tamaki S, Furu M, Takahashi R, Nagayama S, Aoyama T, Nishiyama H, Nakamura E, Katagiri T, Nakamura Y, Ogawa O, Toguchida J.
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Journal Title
PLoS One
Volume: 8
Issue: 1
Pages: e49709-e49709
DOI
Related Report
Peer Reviewed
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