The role of EMT on malignant progression of urothelial carcinoma.

• Project/Area Number: 23592331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: MURAMAKI Mototsugu 神戸大学, 医学部附属病院, 講師 (10448178)
• Co-Investigator(Kenkyū-buntansha): MIYAKE Hideaki 神戸大学, 医学家研究科 泌尿器科学分野 (60379435)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膀胱癌 / 上皮間葉転換 / 尿路上皮癌 / N-cadherin / E-cadherin / E-cadhein / 腎盂癌 / N-cadheri

Research Abstract

Theloss of E-cadherin and gain of N-cadherin expression in on NMIBC appeared to be significantly associated with postoperative recurrence; therefore, the switch from E-cadherin to N-cadherin expression might be involved in the mechanism underlying intravesical recurrence of on NMIBC. Expression profiles of E-cadherin and N-cadherin, particularly the gain of N-cadherin rather than loss of E-cadherin expression, in UC-UUT appeared to be significantly associated with disease recurrence after nephroureterectomy.

Research Products

• [Journal Article] Expression profile of E-cadherin and N-cadherin in non-muscle-invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection (2012)
  • Author(s): Muramaki M, Miyake H, Terakawa T, Kumano M, Sakai I, Fujisawa M
  • Journal Title: Urol Oncol Volume: 30(2) Pages: 6-161
• [Journal Article] Expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract is associated with disease recurrence in patients undergoing nephroureterectomy. (2012)
  • Author(s): Mototsugu Muramaki
  • Journal Title: Urology Volume: 78 Issue: 6 Pages: 1443-1443
  • DOI: 10.1016/j.urology.2011.07.1388
  • Peer Reviewed
• [Journal Article] Expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract is associated with disease recurrence in patients undergoing nephroureterectomy
  • Author(s): Muramaki M, Miyake H, Terakawa T, Kusuda Y, Fujisawa M
  • Journal Title: Urology Volume: 78(6) Pages: 1443-1443
• [Presentation] Expression profile of E-cadherin, N-cadherin and P-cadherin in renal cell carcinoma as prognostic indicators. (2014)
  • Author(s): Mototsugu Muramaki
  • Organizer: Annual congress of Eurpean Association of Urology
  • Place of Presentation: Stockholm
• [Presentation] Expression profile of E-cadherin, N-cadherin and P-cadherin in localized prostate cancer as prognostic indicators (2013)
  • Author(s): 村蒔基次
  • Organizer: 2013癌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2013-10-05
  • Invited
• [Presentation] Expression profile of E-cadherin, N-cadherin and P-cadherin in renal cell carcinoma as prognostic indicators. (2013)
  • Author(s): 村蒔 基次
  • Organizer: 日本癌学会
  • Place of Presentation: 京都
• [Presentation] Expression profile of E-cadherin, N-cadherin and P-cadherin in renal cell carcinoma as prognostic indicators (2012)
  • Author(s): 村蒔基次
  • Organizer: 2012癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-20
  • Invited
• [Presentation] Expression profile of E-cadherin, N-cadherin and P-cadherin in renal cell carcinoma as prognostic indicators. (2012)
  • Author(s): 村蒔基次
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌
• [Presentation] Expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract as a novel predictor of recurrence following nephroureterectomy (2011)
  • Author(s): Mototsugu Muramaki
  • Organizer: American Urological Association, Annual meeting
  • Place of Presentation: Washington, DC