| Project/Area Number |
23592337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagasaki University |
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Principal Investigator |
OHBA Kojiro 長崎大学, 医歯(薬)学総合研究科, 助教 (20593825)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYATA Yasuyoshi 長崎大学, 大学院医歯薬学総合研究科, 准教授 (60380888)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Tomohiro 長崎大学, 大学院医歯薬学総合研究科, 助教 (60622024)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アノイキス / 腎細胞癌 / TWIST / Fer / Anoikis / MMP2 / TAM / RCC |
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| Research Abstract |
We have determined the pathological roles and clinical significance of Twist that was the transcription factor (in the process of the examination), although the mechanism of the anoikis resistance acquisition in the renal cell carcinoma (RCC) is complex and not interpretable. Twist expression is speculated to play important roles in the gain of malignant potential and malignant aggressiveness, including cancer cell invasion and metastasis, and is associated with cause- specific survival in patients with RCC. Multi-variate analyses showed that the up-regulation of Twist influences tumor progression in patients with RCC via the acceleration of MMP2 expression, and the recruitment of macrophages. We suggest that Twist is useful predictor and potential therapeutic target for the treatment of RCC.
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