| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Prostate cancer progress to castration resistant prostate cancer (CRPC) leading to the cancer death. Most of the patients who died with CRPC was initially revealed advanced disease with bone metastasis. We had analyzed the expression profiles of micro-RNAs in advanced prostate cancer. From 2011 to 2012, we confirmed the expression profile of microRNA of advanced prostate cancer. We had further analyzed the functions of down-regulated microRNAs in prostate cancer.
a) miR-145 target FASN1 and controls proliferation, invasion and migration functions of prostate cancer. b) miR a and miR-133a target PNP and controls proliferation, invasion and migration functions of prostate cancer. c) miR-222 and miR-31 involved cancer pathway (by KEGG pathway). d) miR-143/145 forms cluster and target GOLM1 which affect proliferation, invasion and migration functions of prostate cancer.
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