Functional analysis of isolated specific antibody to prostate cancer specific antigen using phage-display method
| Project/Area Number |
23592353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSHINAGA Kiyotaka 藤田保健衛生大学, 医学部, 教授 (30229174)
AKAHORI Yasushi 三重大学, 医学系研究科, 産学官連携講座講師 (80221711)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 前立腺癌 / 前立腺膜特異的抗原（PSMA) / 癌特異的抗原 / 抗体 / 前立腺膜特異的抗原 / 癌特異的抗体 / 癌特異抗原 / 抗体療法 / ファーズデイスプレイ / 完全ヒト型抗体 / 免疫療法 / 前立腺膜抗原（PSMA） / 去勢抵抗性前立腺癌 |
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| Research Abstract |
In Antibody project in Comprehensive Research Institute of Fujita Heath University, Human phage antibody library; AIMS5 library, was established using human extracted B lymphocyte from the almond of dozens of people, marrow, peripheral blood, umbilical cord blood. Applying the phage-display method, specific antibody to PSMA, prostate specific membrane antibody, (75-10) was isolated from this library using ICOS method, J Immunol Methods. 351:1-12, 2009. Specific antibody to PSMA (75-10) was demonstrated to show the specific prostate membane-specific reactivity to prostate cancer tissue (the specific stainability to cell surface membrane) and an in vitro cancer cytotoxicity in cultured and a clinical specimen of the prostate cancer.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Selection and analysis of anti-cancer antibodies for cancer therapy obtained from antibody phage library2011
Author(s)
Kurosawa G,Sumitomo M,Ukai Y,Subera J,Muramatsu C,Eguchi K,Tanaka-Hashiba M,Sugiura M,Ando M,Morita M,Inaba K,Morigaki S,Takasaki A,Miyakawa S,Uyama I,Maeda K,Shiroki R,Hoshinaga K,Mizoguchi Y,Hattori Y,Sugioka A,Sugiura M,Kurosawa Y
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Journal Title
Cancer Science
Volume: 102
Pages: 175-181
NAID
Related Report
Peer Reviewed
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[Presentation] 当院における去勢抵抗性前立腺癌(CRPC)に対するDoxetaxel療法の長期成績2011
Author(s)
引地克,白木良一,河合昭浩,西野将,深谷孝介,彦坂和信,平野泰広,深見直彦,石瀬仁司,丸山高広,佐々木ひと美,日下守,石川清仁,星長清隆
Organizer
第49回日本癌治療学会学術集会
Place of Presentation
名古屋
Related Report
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