An investigation of novel treatment of prostate cancer through ubiquitinated protein accumulation

• Project/Area Number: 23592355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: National Defense Medical College
• Principal Investigator: SATO Akinori 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (00296675)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ユビキチン化蛋白蓄積 / 前立腺癌 / ユビキチン化蛋白 / 小胞体ストレス / ヒストンアセチル化 / ユビキチン化 / SAHA / bortezomib / ritonavir

Research Abstract

Unfolded proteins are normally repaired by the proteasome. I postulated that vorinostat or ritonavir increased unfolded proteins and bortezomib in combination would inhibit their degradation, leading to cell death. As expected, the combination therapies caused ubiquitinated proteins to accumulate in the cell and killed prostate cancer cells.

Research Products

• [Journal Article] Vorinostat and Bortezomib Synergistically Cause Ubiquitinated Protein Accumulation in Prostate Cancer Cells (2012)
  • Author(s): Sato, A., Asano, T., Ito, K. and Asano, T.
  • Journal Title: J. Urol Volume: 188(6) Pages: 2410-2418
• [Journal Article] Vorinostat and bortezomib synergistically cause ubiquitinated protein accumulation in prostate cancer cells. (2012)
  • Author(s): Sato Akinori
  • Journal Title: Journal of Urology Volume: 188 Issue: 6 Pages: 2410-2418
  • DOI: 10.1016/j.juro.2012.07.108
  • Peer Reviewed
• [Presentation] Might cancer cells be killed by something accumulating in them? : The idea of treating urological malignancies by causing the accumulation of ubiquitinated proteins (2013)
  • Author(s): Sato, A
  • Organizer: Heinrich Heine University Lecture
  • Place of Presentation: Düsseldorf, Germany
  • Invited
• [Presentation] 前立腺癌に対するvorinostatとbortezomibを用いた併用療法の開発:ユビキチン化蛋白蓄積を介する新たな治療戦略 (2013)
  • Author(s): 佐藤全伯、浅野貴子、伊藤敬一、浅野友彦
  • Organizer: 第22回泌尿器科分子・細胞研究会
  • Place of Presentation: 高知
• [Presentation] 前立腺癌に対するvorinostatとbortezomibを用いた併用療法の開発：ユビキチン化蛋白蓄積を介する新たな治療戦略 (2013)
  • Author(s): 佐藤全伯
  • Organizer: 第22回泌尿器科分子・細胞研究会
  • Place of Presentation: 高知
• [Presentation] Might cancer cells be killed by something accumulating in them? : The idea of treating urological malignancies by causing the accumulation of ubiquitinated proteins (2013)
  • Author(s): 佐藤全伯
  • Organizer: Heinrich Heine大学講演
  • Place of Presentation: デュッセルドルフ
  • Invited
• [Presentation] 前立腺癌に対するvorinostatとbortezomibによる新規治療 (2012)
  • Author(s): 佐藤全伯、浅野貴子、伊藤敬一、浅野友彦
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Ritonavir interacts with bortezomib synergistically to enhance endoplasmic reticulum stress in prostate cancer cells (2012)
  • Author(s): Sato, A., Asano, T., Ito, K. and Asano, T
  • Organizer: The 107th American Urological Association Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] What wandering along the Rhein brought me : The idea of treating urological malignancies by causing the accumulation of ubiquitinated proteins (2012)
  • Author(s): Sato, A
  • Organizer: The 100th Japanese Urological Association Annual Meeting
  • Place of Presentation: Yokohama, Japan
  • Invited
• [Presentation] 前立腺癌に対する新規治療の開発:ユビキチン化蛋白蓄積による戦略 (2012)
  • Author(s): 佐藤全伯、浅野貴子、伊藤敬一、浅野友彦
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] Vorinostat interacts with bortezomib to enhance protein ubiquitination synergistically in prostate cancer cells (2012)
  • Author(s): Sato, A., Asano, T., Ito, K. and Asano, T.
  • Organizer: The 27th European Association of Urology Congress
  • Place of Presentation: Paris, France
• [Presentation] What wandering along the Rhein brought me: The idea of treating urological malignancies by causing the accumulation of ubiquitinated proteins (2012)
  • Author(s): 佐藤全伯
  • Organizer: 第100回日本泌尿器科学会総会(International Session)
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Ritonavir interacts with bortezomib synergistically to enhance endoplasmic reticulum stress in prostate cancer cells (2012)
  • Author(s): 佐藤全伯
  • Organizer: 第107回米国泌尿器科会議
  • Place of Presentation: アトランタ
• [Presentation] Vorinostat interacts with bortezomib to enhance protein ubiquitination synergistically in prostate cancer cells (2012)
  • Author(s): 佐藤全伯
  • Organizer: 第27回ヨーロッパ泌尿器科学会
  • Place of Presentation: パリ
• [Presentation] 前立腺癌に対する新規治療の開発: ユビキチン化蛋白蓄積による戦略 (2012)
  • Author(s): 佐藤全伯
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://researchmap.jp/zenpaku/
• [Remarks] ReaD&Researchmap佐藤全伯
  • URL: http://researchmap.jp/zenpaku/