• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Tissue Engineering for lower urinary tract by autologous bone marrow stem cell and adispose tissue

Research Project

Project/Area Number 23592363
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionShinshu University

Principal Investigator

ISHIZUKA Osamu  信州大学, 医学部, 准教授 (20184541)

Co-Investigator(Kenkyū-buntansha) IMAMURA Tetsuya  信州大学, 医学部, 講師 (00467143)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords移植・再生医療 / 骨髄幹細胞 / 脂肪細胞 / 膀胱 / 尿道括約筋 / 脂肪幹細胞 / 再生医学 / 細胞・組織 / 生体機能利用 / 脳神経疾患
Research Abstract

From the clinical point of view, urethral sphincter reconstruction is important to prevent urinary incontinence in the field of bladder reconstruction. At first, we could culture and proliferate the bone-marrow-derived mesenchymal stem cells derived from the femur of rabbit and abdominal adipose tissue derived stem cells. The cultured stem cells were implanted into the injured urethral sphincter, and we could found the reconstruction of the urethral sphincter by histological methods (immunohistochemistry, RT-PCR method) and functional study.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Implantation of autologous adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra2014

    • Author(s)
      Sudha, G.S., Imamura, T., Ishizuka, O., Zhang, L., Yamagishi, T., Yokoyama, H., Minagawa, T., Ogawa, T., Kurizaki, Y., Kato, H., Nishizawa, O.
    • Journal Title

      Tissue Eng. Part A

      Volume: (Epub ahead of print)

    • NAID

      120007100147

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Editorial commnet from Dr. Ishizuka to periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress incontinence: report of three initial cases.2013

    • Author(s)
      Ishizuka O
    • Journal Title

      Int.J.Urol.

      Volume: 20 Issue: 2 Pages: 240-240

    • DOI

      10.1111/j.1442-2042.2012.03145.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells implanted into radiation-injured urinary bladders reconstructe functional bladder tissues in rats2012

    • Author(s)
      Imamura, T., Ishizuka, O., Zhang, L., Hida, S., Sudha, G.S., Kato, H., Nishizawa, O.
    • Journal Title

      Tissue Eng Part A

      Volume: 18(15-16) Pages: 1698-709

    • NAID

      120007110571

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone Marrow-Derived Cells Implanted into Radiation-Injured Urinary Bladders Reconstruct Functional Bladder Tissues in Rats2012

    • Author(s)
      Imamura T, Ishizuka O, Lei Z, Hida S, Sudha GS, Kato H, Nishizawa O
    • Journal Title

      Tissue Eng Part A

      Volume: (in press) Issue: 15-16 Pages: 1698-1709

    • DOI

      10.1089/ten.tea.2012.0061

    • NAID

      120007110571

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autologous bone marrow-derived cells regenerate urethral sphincters2012

    • Author(s)
      Imamura, T., Ishizuka, O., Nishizawa, O.
    • Journal Title

      LUTS

      Volume: 4 Issue: s1 Pages: 87-94

    • DOI

      10.1111/j.1757-5672.2011.00136.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Editorial Comment from Dr Ishizuka to periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: report of three initial cases2012

    • Author(s)
      Ishizuka O
    • Journal Title

      Int. J.Urol.

      Volume: Mar 27 Issue: 7 Pages: 659-659

    • DOI

      10.1111/j.1442-2042.2012.03011.x

    • NAID

      10030824000

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Implantation of autologous bone marrow-derived cells reconstructs functional urethral sphincters in rabbits2011

    • Author(s)
      Imamura, T., Ishizuka, O., Kinebuchi, Y., Kurizaki, Y., Nakayama, T., Ishikawa, M., Nishizawa, O.
    • Journal Title

      Tissue Eng. Part A

      Volume: 17(7-8) Pages: 1069-81

    • NAID

      120007110472

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implantation of autologous bone-marrow-derived cells reconstructs functional urethral sphincters in rabbits.2011

    • Author(s)
      Imamura T, Ishizuka O, Kinebuchi Y, Nakayama T, Ishikawa M, Nishizawa O
    • Journal Title

      Tissue Eng PartA

      Volume: 17 Pages: 1069-81

    • NAID

      120007110472

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] The implantation of autologous adipose-derived cells makes the functional regeneration of frozen-injured rabbit urethra2013

    • Author(s)
      Sudha, G., Imamura, T., Ishizuka, O., Zhang, L., Noguchi, W., Yamagishi, T., Yokoyama, H., Kurizaki, Y., Nishizawa, O., Andersson, K.E.
    • Organizer
      33th congress of the Societe Internationale d'Urologie
    • Place of Presentation
      Vancouver(Urology 82(9) suppl , S96, 2013). (presented by O.Ishizuka)
    • Related Report
      2013 Final Research Report
  • [Presentation] The implantation of autologous adipose-derived celss makes the functional regeneration of frozen-injured rabbit urethra2013

    • Author(s)
      Sudha, G., Imamura, T., Ishizuka, O., Zhang, L., Noguchi, W., Yamagishi, T., Yokoyama, H., Kurizaki, Y., Nishizawa, O., Andersson, K.E.
    • Organizer
      33th congress of the Societe Internationale d’Urologie
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Implantation of Bone Marrow-derived cells recovers tissue structures and functions of radiation-injured urinary bladders in rats2012

    • Author(s)
      Imamura, T., Ishizuka, O., Kurizaki, Y., Yokoyama, H., Noguchi, W., Yamagishi, T., Zhang, L., Kato, H., Nishizawa, O.
    • Organizer
      2012 annual meeting of American Urological Association
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Final Research Report
  • [Presentation] Implantation of Bone Marrow-derived cells recovers tissue structures and functions of radiation-injured urinary bladders in rats.2012

    • Author(s)
      Imamura, T., Ishizuka, O., Kurizaki, Y., Yokoyama, H., Noguchi, W., Yamagishi, T., Zhang, L., Kato, H., Nishizawa, O.
    • Organizer
      2012 annual meeting of American Urological Asscociation
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Implantation of autologous bone marrow-derived cells recovers urethral sphincter in rabbits2011

    • Author(s)
      Imamura, T., Ishizuka, O., Kurizaki, Y., Ishikawa, M., Noguchi, A., Zhang, L., Ichino, M., Kato, H., Nishizawa, O.
    • Organizer
      The 41^<th> Annual Meeting of the International Continence Society
    • Place of Presentation
      Glasgow
    • Related Report
      2013 Final Research Report
  • [Presentation] Implantation of autologous bone marrow -derived cells recovers urethral spinster composed of striated and smooth muscle layers in rabbits2011

    • Author(s)
      Imamura T, Ishizuka O et al.
    • Organizer
      41st annual meeting of the international continence society
    • Place of Presentation
      Glasgow, UK
    • Related Report
      2011 Research-status Report
  • [Book] 下部尿路機能ポケットマニュアル2012

    • Author(s)
      石塚 修、井川靖彦
    • Publisher
      メデイカルレビュー
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi