Tissue Engineering for lower urinary tract by autologous bone marrow stem cell and adispose tissue
Project/Area Number |
23592363
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Shinshu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
IMAMURA Tetsuya 信州大学, 医学部, 講師 (00467143)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 移植・再生医療 / 骨髄幹細胞 / 脂肪細胞 / 膀胱 / 尿道括約筋 / 脂肪幹細胞 / 再生医学 / 細胞・組織 / 生体機能利用 / 脳神経疾患 |
Research Abstract |
From the clinical point of view, urethral sphincter reconstruction is important to prevent urinary incontinence in the field of bladder reconstruction. At first, we could culture and proliferate the bone-marrow-derived mesenchymal stem cells derived from the femur of rabbit and abdominal adipose tissue derived stem cells. The cultured stem cells were implanted into the injured urethral sphincter, and we could found the reconstruction of the urethral sphincter by histological methods (immunohistochemistry, RT-PCR method) and functional study.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Implantation of autologous adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra2014
Author(s)
Sudha, G.S., Imamura, T., Ishizuka, O., Zhang, L., Yamagishi, T., Yokoyama, H., Minagawa, T., Ogawa, T., Kurizaki, Y., Kato, H., Nishizawa, O.
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Journal Title
Tissue Eng. Part A
Volume: (Epub ahead of print)
NAID
Related Report
Peer Reviewed
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[Journal Article] Bone marrow-derived cells implanted into radiation-injured urinary bladders reconstructe functional bladder tissues in rats2012
Author(s)
Imamura, T., Ishizuka, O., Zhang, L., Hida, S., Sudha, G.S., Kato, H., Nishizawa, O.
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Journal Title
Tissue Eng Part A
Volume: 18(15-16)
Pages: 1698-709
NAID
Related Report
Peer Reviewed
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[Journal Article] Implantation of autologous bone marrow-derived cells reconstructs functional urethral sphincters in rabbits2011
Author(s)
Imamura, T., Ishizuka, O., Kinebuchi, Y., Kurizaki, Y., Nakayama, T., Ishikawa, M., Nishizawa, O.
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Journal Title
Tissue Eng. Part A
Volume: 17(7-8)
Pages: 1069-81
NAID
Related Report
Peer Reviewed
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[Presentation] The implantation of autologous adipose-derived cells makes the functional regeneration of frozen-injured rabbit urethra2013
Author(s)
Sudha, G., Imamura, T., Ishizuka, O., Zhang, L., Noguchi, W., Yamagishi, T., Yokoyama, H., Kurizaki, Y., Nishizawa, O., Andersson, K.E.
Organizer
33th congress of the Societe Internationale d'Urologie
Place of Presentation
Vancouver(Urology 82(9) suppl , S96, 2013). (presented by O.Ishizuka)
Related Report
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[Presentation] The implantation of autologous adipose-derived celss makes the functional regeneration of frozen-injured rabbit urethra2013
Author(s)
Sudha, G., Imamura, T., Ishizuka, O., Zhang, L., Noguchi, W., Yamagishi, T., Yokoyama, H., Kurizaki, Y., Nishizawa, O., Andersson, K.E.
Organizer
33th congress of the Societe Internationale d’Urologie
Place of Presentation
Vancouver, Canada
Related Report
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[Presentation] Implantation of Bone Marrow-derived cells recovers tissue structures and functions of radiation-injured urinary bladders in rats2012
Author(s)
Imamura, T., Ishizuka, O., Kurizaki, Y., Yokoyama, H., Noguchi, W., Yamagishi, T., Zhang, L., Kato, H., Nishizawa, O.
Organizer
2012 annual meeting of American Urological Association
Place of Presentation
Atlanta
Related Report
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[Presentation] Implantation of Bone Marrow-derived cells recovers tissue structures and functions of radiation-injured urinary bladders in rats.2012
Author(s)
Imamura, T., Ishizuka, O., Kurizaki, Y., Yokoyama, H., Noguchi, W., Yamagishi, T., Zhang, L., Kato, H., Nishizawa, O.
Organizer
2012 annual meeting of American Urological Asscociation
Place of Presentation
Atlanta, USA
Related Report
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[Presentation] Implantation of autologous bone marrow-derived cells recovers urethral sphincter in rabbits2011
Author(s)
Imamura, T., Ishizuka, O., Kurizaki, Y., Ishikawa, M., Noguchi, A., Zhang, L., Ichino, M., Kato, H., Nishizawa, O.
Organizer
The 41^<th> Annual Meeting of the International Continence Society
Place of Presentation
Glasgow
Related Report
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