| Project/Area Number |
23592368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
TSUJIMURA Akira 大阪大学, 医学(系)研究科(研究院), 准教授 (40294053)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAGAWA Yasushi 大阪大学, 大学院医学系研究科, 講師 (70362704)
TAKAO Tetsuya 大阪大学, 大学院医学系研究科, 講師 (30379177)
NOMURA Taisei 独立行政法人医薬基盤研究所) (90089871)
松岡 庸洋 大阪大学, 医学(系)研究科(研究院), 助教 (10379183)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 前立腺肥大症 / 動物モデル / 5α還元酵素阻害剤 / PDE5阻害剤 / super-SCIDマウス / デュタステライド / タダラフィル / Super-SCIDマウス / ヒトBPHモデル |
|---|
| Research Abstract |
We evaluated histological changes in human prostate tissue caused by dutasteride and tadalafil, after establishing a xenograft model with improved severe combined immunodeficient mice. Our data showed that a proliferation index was significantly reduced and apoptosis rate were significantly increased after 2 months of dutasteride and tadalafil treatment, compared with control. These results provide a therapeutic potential of both drugs for reducing prostate volume in patients with BPH.
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