Direct effect of 5 alpha reductase inhibitora and PDE5 inhibitor on prostatic tissue
| Project/Area Number |
23592368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
TSUJIMURA Akira 大阪大学, 医学(系)研究科(研究院), 准教授 (40294053)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAGAWA Yasushi 大阪大学, 大学院医学系研究科, 講師 (70362704)
TAKAO Tetsuya 大阪大学, 大学院医学系研究科, 講師 (30379177)
NOMURA Taisei 独立行政法人医薬基盤研究所) (90089871)
松岡 庸洋 大阪大学, 医学(系)研究科(研究院), 助教 (10379183)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 前立腺肥大症 / 動物モデル / 5α還元酵素阻害剤 / PDE5阻害剤 / super-SCIDマウス / デュタステライド / タダラフィル / Super-SCIDマウス / ヒトBPHモデル |
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| Research Abstract |
We evaluated histological changes in human prostate tissue caused by dutasteride and tadalafil, after establishing a xenograft model with improved severe combined immunodeficient mice. Our data showed that a proliferation index was significantly reduced and apoptosis rate were significantly increased after 2 months of dutasteride and tadalafil treatment, compared with control. These results provide a therapeutic potential of both drugs for reducing prostate volume in patients with BPH.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Finger taps and constipation are closely related to symptoms of overactive bladder in male patients with Parkinson's disease2014
Author(s)
Tsujimura A, Yamamoto Y, Sakoda S, Okuda H, Yamamoto K, Fukuhara S, Yoshioka I, Kiuchi H, Takao T, Miyagawa Y, Nonomura N
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Journal Title
Int J Urol
Volume: 21
Pages: 69-73
Related Report
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[Journal Article] Is low testosterone concentration a risk factor for metabolic syndrome in healthy middle-aged men?2013
Author(s)
Tsujimura A, Miyagawa Y, Takezawa K, Okuda H, Fukuhara S, Kiuchi H, Takao T, Yamamoto R, Nishida M, Yamauchi-Takihara K, Moriyama T, Nonomura N
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Journal Title
Urology
Volume: 82
Pages: 814-819
Related Report
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[Journal Article] Low serum free testosterone level is associated with carotid intima-media thickness in middle aged Japanese men2012
Author(s)
Tsujimura A, Yamamoto R, Okuda H, Yamamoto K, Fukuhara S, Kiuchi H, Takao T, Miyagawa Y, Nishida M, Yamauchi-Takihara K, Moriyama T, Nonomura N
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Journal Title
Endocrine J
Volume: 59
Pages: 809-815
NAID
Related Report
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[Journal Article] A survey of overactive bladder symptoms influencing bother before and after treatment with tamsulosin hydrochloride in Japanese benign prostatic hyperplasia patients2011
Author(s)
Tsujimura A, Takao T, Miyagawa Y, Okuda H, Yamamoto K, Fukuhara S, Nakayama J, Ueda T, Kiuchi H, Hirai T, Nonomura N, Tsujimoto Y, Miura H, Kannno N, Higashino M, Nakamura Y, Nishimura K, Okuyama A
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Journal Title
Urology
Volume: 78
Pages: 1058-1062
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