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Identification and functional analysis of cytokine signal transduction-related factors in human urethral rhabdosphincter

Research Project

Project/Area Number 23592372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionOita University

Principal Investigator

MIMATA hiromitsu  大分大学, 医学部, 教授 (60219714)

Co-Investigator(Kenkyū-buntansha) SATO Fuminori  大分大学, 医学部, 准教授 (30305049)
SUMINO Yasuhiro  大分大学, 医学部, 講師 (30325716)
MORI Kenichi  大分大学, 医学部, 助教 (00579013)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords外尿道括約筋 / 尿失禁 / サイトカイン
Research Abstract

We explored the identification of specifically expressed factors in human RS and examined the effect on RS satellite cell growth, differentiation and the mechanisms of intracellular signal transduction by those factors. TGF-beta highly increased in ECM of RS by immunohistochemistry. Moreover, we identified that TGF-beta could inhibit cell proliferation and differentiation of human RS satellite cells through Smad2/3 phosphorylation.In the experiments using rat, urethral fnctions significantly decreased with aging after child-birth, and it has been considered that aging after child-birth attenuated urethral support. On the other hand, transcripts of ECM in urethra were significantly decreased with aging, although there were no significant changes in those of inflammatory cytokines between young and aged groups. Reduction of ECM or chronic inflammatory state in urethra including RS with aging might attenuate urethral support system,and be a part of SUI in elderly people.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (14 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Therapeutic effects of IGF-1 on stress urinary incontinence in rats with simulated childbirth trauma2014

    • Author(s)
      Sumino Y, Yoshikawa S, Mimata H, Yoshimura N
    • Journal Title

      J Urol

      Volume: 191 Pages: 529-38

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia2014

    • Author(s)
      Hirai K, Nomura T, Yamasaki M, Inoue T, Narimatsu T, Chisato Nakada PD, Yoshiyuki Tsukamoto PD, Matsuura K, Sato F, Moriyama M, Mimata H
    • Journal Title

      Urol Oncol

      Volume: 32 Pages: 101-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CLP1 links tRNA metabolism to progressive motor-neuron loss2013

    • Author(s)
      Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ,Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM
    • Journal Title

      Nature

      Volume: 495 Pages: 474-480

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regenerative medicine as a new therapeutic strategy for lower urinary tract dysfunction2013

    • Author(s)
      Sumino Y, Mimata H
    • Journal Title

      Int J Urol

      Volume: 20 Pages: 670-5

    • NAID

      10031190511

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia2013

    • Author(s)
      Nomura T, Yamasaki M, Hirai K, Inoue T, Sato R, Matsuura K, Moriyama M, Sato F, Mimata H
    • Journal Title

      Mol Cancer

      Volume: 8(12) Pages: 27-27

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myostatin inhibits proliferation of human urethral rhabdosphincter satellite cells2013

    • Author(s)
      Akita Y, Sumino Y, Mori KI, Nomura T, Sato F, Mimata H.
    • Journal Title

      Int J Urol.

      Volume: 20 Pages: 522529-522529

    • NAID

      10031177689

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myostatin inhibits proliferation of human urethral rhabdosphincter satellite cells2012

    • Author(s)
      Akita Y, Sumino Y, Mori K, Nomura T, Sato F, Mimata H
    • Journal Title

      Int J Urol

      Pages: 522-9

    • NAID

      10031177689

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of procalcitonin in patients on chronic hemodialysis : procalcitonin is not related with increased serum calcitonin2012

    • Author(s)
      Mori K, Noguchi M, Sumino Y, Sato F, Mimata H
    • Journal Title

      ISRN Urol

      Pages: 431859-431859

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Left Transperitoneal Adrenalectomywith a Laparoendoscopic Single-Site SurgeryCombined Technique : InitialCaseReports2011

    • Author(s)
      Sumino Y, Nakano D, Mori K, Nomura T, Sato F and Mimata H
    • Journal Title

      Case report in Med

      Pages: 651380-651380

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-TermCryopreservationof Pyramidalis Muscle Specimens as a Source of Striated Muscle Stem Cells for Treatment of Post-Prostatectomy Stress Urinary Incontinence2011

    • Author(s)
      Sumino Y, Hirata Y, Hanada M, Akita Y, Sato F and Mimata H
    • Journal Title

      Prostate

      Pages: 1225-30

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Association of remodelling of extracellular matrix and urethral dysfunction inducing stress urinary incontinence in aged, multiparous rats2013

    • Author(s)
      Sumino Y, Yoshikawa S, Mimata H, Yoshimura N
    • Organizer
      ICS 2013 (Annual Meeting of the International Continence Society)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Insulin-like growth factor-1 as an important endogenous growth factor for the recovery from stress urinary incontinence in rats with simulated childbirth injury2013

    • Author(s)
      Sumino Y, Yoshikawa S, Mimata H, Yoshimura N
    • Organizer
      AUA2013
    • Place of Presentation
      San Diego CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Therapeutic effects of insulin-like growth factor-1 on stress urinary incontinence in rats with simulated child birth trauma injury2013

    • Author(s)
      Sumino Y, Yoshikawa S, Mimata H, Yoshimura N
    • Organizer
      American Urology Association 2013
    • Place of Presentation
      Atlanta GA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膣拡張による腹圧性尿失禁モデルラットにおけるInsulin-like growth actor-1(IGF-1)の治療効果2012

    • Author(s)
      住野泰弘、吉川悟、三股浩光,吉村直樹
    • Organizer
      第9回泌尿器科再建再生研究会
    • Place of Presentation
      湯布院
    • Year and Date
      2012-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Therapeutic effects of insulin-like growth factor-1 on stress urinary incontinence in rats with simulated child birth trauma injury2012

    • Author(s)
      Sumino Y, Yoshikawa S, Mimata H, Yoshimura N
    • Organizer
      AUA
    • Place of Presentation
      Atlanta GA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト外尿道括約筋衛星細胞におけるTGF-βの増殖抑制作用(第2報)2012

    • Author(s)
      三木大輔
    • Organizer
      第21回泌尿器科分子・細胞研究会
    • Place of Presentation
      札幌市
    • Related Report
      2011 Research-status Report
  • [Presentation] 腹圧性尿失禁に対する外尿道括約筋自己再生を目指して2011

    • Author(s)
      住野泰弘、三股浩光
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋(シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] プロテオミクスによる外尿道括約筋特異蛋白の同定2011

    • Author(s)
      秋田泰之
    • Organizer
      第8回泌尿器科再建再生研究会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト外尿道括約筋衛星細胞におけるTGF-βの増殖抑制作用2011

    • Author(s)
      三木大輔
    • Organizer
      第8回泌尿器科再建再生研究会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト外尿道括約筋に高発現する分子の同定2011

    • Author(s)
      秋田泰之
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井市
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト外尿道括約筋衛星細胞におけるTGF-βの増殖抑制作用2011

    • Author(s)
      三木大輔
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井市
    • Related Report
      2011 Research-status Report
  • [Presentation] Distinct Gene and Protein Expression Profile in Human Urethral Rhabdosphincter2011

    • Author(s)
      秋田泰之
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Research-status Report
  • [Presentation] Insulin-like growth factor-1 (IGF-1) accelerates recovery from stress urinary incontinence in rats with simulated child birth trauma injury through Akt signal transduction pathway2010

    • Author(s)
      Sumino Y, Yoshikawa S, Mimata H, Yoshimura N
    • Organizer
      ICS 2012 (Annual Meeting of the International Continence Society)
    • Place of Presentation
      Peking, China
    • Related Report
      2013 Final Research Report
  • [Presentation] 外尿道括約筋衛星細胞におけるTGF-β機能解析

    • Author(s)
      三木大輔
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Book] 泌尿器科基礎手術学泌尿器科手術の術前・術後管理.ベッドサイド泌尿器科学(改訂第4版)2013

    • Author(s)
      三股浩光,佐藤文憲
    • Related Report
      2013 Final Research Report
  • [Book] 泌尿器科疾患:後腹膜腫瘍,後腹膜線維症.今日の治療指針.2012年版2012

    • Author(s)
      三股浩光(山口徹、北原光夫、福井次矢)
    • Publisher
      医学書院.東京
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.med.oita-u.ac.jp/hinyoki/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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