Identification and functional analysis of cytokine signal transduction-related factors in human urethral rhabdosphincter
| Project/Area Number |
23592372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Fuminori 大分大学, 医学部, 准教授 (30305049)
SUMINO Yasuhiro 大分大学, 医学部, 講師 (30325716)
MORI Kenichi 大分大学, 医学部, 助教 (00579013)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 外尿道括約筋 / 尿失禁 / サイトカイン |
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| Research Abstract |
We explored the identification of specifically expressed factors in human RS and examined the effect on RS satellite cell growth, differentiation and the mechanisms of intracellular signal transduction by those factors. TGF-beta highly increased in ECM of RS by immunohistochemistry. Moreover, we identified that TGF-beta could inhibit cell proliferation and differentiation of human RS satellite cells through Smad2/3 phosphorylation.In the experiments using rat, urethral fnctions significantly decreased with aging after child-birth, and it has been considered that aging after child-birth attenuated urethral support. On the other hand, transcripts of ECM in urethra were significantly decreased with aging, although there were no significant changes in those of inflammatory cytokines between young and aged groups. Reduction of ECM or chronic inflammatory state in urethra including RS with aging might attenuate urethral support system,and be a part of SUI in elderly people.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia2014
Author(s)
Hirai K, Nomura T, Yamasaki M, Inoue T, Narimatsu T, Chisato Nakada PD, Yoshiyuki Tsukamoto PD, Matsuura K, Sato F, Moriyama M, Mimata H
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Journal Title
Urol Oncol
Volume: 32
Pages: 101-9
Related Report
Peer Reviewed
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[Journal Article] CLP1 links tRNA metabolism to progressive motor-neuron loss2013
Author(s)
Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ,Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM
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Journal Title
Nature
Volume: 495
Pages: 474-480
Related Report
Peer Reviewed
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