The effect of afferent activation from prostate on rat bladder overactivity

Research Project

Project/Area Number	23592373
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Urology
Research Institution	Fukushima Medical University
Principal Investigator	AIKAWA Ken 福島県立医科大学, 医学部, 准教授 (80295419)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	前立腺 / 過活動膀胱 / 求心性刺激 / c-fos / アンジオテンシンII / 下部尿路機能 / ノルアドレナリン / アンジオテンシン
Research Abstract	The present study tried to determine whether the increased afferent activation from prostate is the pathophysiology of overactive bladder in males. Angiotensin II increased the discharge of noradrenaline from prostate. In addition, angiotensin II increased the afferent activity of prostate as indicated by c-fos expression in L6. Furthermore, continuous cystometry demonstrated that angiotensin II shortened bladder contraction intervals. Taken together, this study suggests that the afferent activity of prostate involves overactive bladder and angiotensin II type 1 receptor antagonists may be therapeutic medicine.