| Project/Area Number |
23592380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Horo-omi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (10214446)
TAKAHASHI Masayuki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (50325255)
FUKUMORI Tomoharu 徳島大学, 病院, 講師 (10314874)
NAKATSUJI Hiroyoshi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 非常勤講師 (50437638)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腎虚血再灌流障害 / ischemic preconditioning / remoteorgen ischemic / 腹腔境下腎部分切除 / 心筋保護作用 / remotergan ischemic / 腹腔境下腎部分切除術 / remoteorgan ischemic |
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| Research Abstract |
We made a rat model of renal ischemia/reperfusion and examined the effectiveness of ischemic preconditioning for preventing renal ischemia/reperfusion injury. We also sought to reveal the underlying mechanism of ischemic preconditioning.
We found that ischemic preconditioning could efficiently reduce the damage for uriniferous tubules by renal ischemia/reperfusion. We focused on Preconditioning inducible factor-A (PICA) as a factor that is related to the damage of uriniferous tubules after renal ischemia/reperfusion according to the results of comprehensive gene expression analyses with DNA microarray. We found that the expression of this gene was conspicuously elevated at mRNA and protein level in HK2 cells when the cells were exposed to the hypoxic condition. As this gene was shown to regulate the molecules that are related to endoplasmic reticulum stress, we are in progress for analyzing the relationship of this gene and endoplasmic reticulum stress.
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