Mechanism of deteriorated recovery of cavernous nerve function with aging.
Project/Area Number |
23592381
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Juntendo University (2013) Teikyo University (2011-2012) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
井手 久満 帝京大学, 医学部, 准教授 (00301383)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 再生医学 / アンドロロジー / 海綿体神経 / 加齢 / 神経機能回復 / 神経栄養因子 / Neurturin / GFRa-2 / 神経再生 / 勃起能 / 根治的前立腺摘除術 / 海綿体神経機能回復 / クーリッジ効果 / 肥満 / nNOS陽性神経 |
Research Abstract |
The cohabitation with female rats w/ rotation induces the recovery from ED following CN injury. We established the rehabilitation animal model using the 'Coolidge effect.' Preoperative administration of Eviprostat improved the erectile function following cavernous nerve injury, which implicated that the anti-inflammatory and anti-oxidative effect induces the early recovery of erectile function following cavernous nerve injury. Higher age has a negative impact on the nNOS-positive ganglionic neuron count in human. This result will lead to the rationale why older people show the poor outcome in their recovery of erection following radical prostatectomy.
|
Report
(4 results)
Research Products
(43 results)
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[Journal Article] Correlation between the Japanese Aging Male Questionnaire (JAMQ) and Aging Male's Symptom (AMS) scale in Japanese male.2014
Author(s)
Horie S, Hisasue S, Nakao M, Ide H, China T, Nagae M, Saito K, Isotani S, Yamaguchi R, Muto S, Kumamoto Y
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Journal Title
Aging Male
Volume: 17
Issue: 1
Pages: 35-41
DOI
Related Report
Peer Reviewed
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[Journal Article] Maintenance therapy with intravesical bacillus Calmette-Guerin in patients with intermediate- or high-risk non-muscle-invasive bladder cancer.2013
Author(s)
Muto S, Nakajima A, Horiuchi A, Inoue M, China T, Saito K, Isotani S, Hisasue S, Yamaguchi R, Ide H, Horie S.
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Journal Title
Jpn J Clin Oncol.
Volume: 43
Issue: 3
Pages: 305-313
DOI
Related Report
Peer Reviewed
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[Journal Article] <b>Hochuekkito Efficacy in Late-Onset Hypogonadism (LOH) Patients </b>2013
Author(s)
熊本 友香, 久末 伸一, 安田 弥子, 井手 久満, 知名 俊幸, 井上 正浩, 斉藤 恵介, 磯谷 周治, 山口 雷蔵, 武藤 智, 堀江 重郎
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Journal Title
Kampo Medicine
Volume: 64
Issue: 3
Pages: 160-165
DOI
NAID
ISSN
0287-4857, 1882-756X
Related Report
Peer Reviewed
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