Mechanism of deteriorated recovery of cavernous nerve function with aging.

• Project/Area Number: 23592381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Juntendo University (2013); Teikyo University (2011-2012)
• Principal Investigator: HISASUE Shin-ichi 順天堂大学, 医学部, 准教授 (90404673)
• Co-Investigator(Kenkyū-buntansha): 井手 久満 帝京大学, 医学部, 准教授 (00301383)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 再生医学 / アンドロロジー / 海綿体神経 / 加齢 / 神経機能回復 / 神経栄養因子 / Neurturin / GFRa-2 / 神経再生 / 勃起能 / 根治的前立腺摘除術 / 海綿体神経機能回復 / クーリッジ効果 / 肥満 / nNOS陽性神経

Research Abstract

The cohabitation with female rats w/ rotation induces the recovery from ED following CN injury. We established the rehabilitation animal model using the 'Coolidge effect.' Preoperative administration of Eviprostat improved the erectile function following cavernous nerve injury, which implicated that the anti-inflammatory and anti-oxidative effect induces the early recovery of erectile function following cavernous nerve injury. Higher age has a negative impact on the nNOS-positive ganglionic neuron count in human. This result will lead to the rationale why older people show the poor outcome in their recovery of erection following radical prostatectomy.

Research Products

• [Journal Article] Correlation between the Japanese Aging Male Questionnaire (JAMQ) and Aging Male's Symptom (AMS) scale in Japanese male. (2014)
  • Author(s): Horie S, Hisasue S, Nakao M, Ide H, China T, Nagae M, Saito K, Isotani S, Yamaguchi R, Muto S, Kumamoto Y
  • Journal Title: Aging Male Volume: 17 Issue: 1 Pages: 35-41
  • DOI: 10.3109/13685538.2013.801436
  • Peer Reviewed
• [Journal Article] Role of Androgen in the Elderly. What is LOH syndrome? (2013)
  • Author(s): Hisasue S and Horie S
  • Journal Title: Clin Calcium Volume: 23 Pages: 1101-7
• [Journal Article] 中等度または高リスクの筋層非浸潤性膀胱癌患者におけるBCG膀胱内投与による維持療法(Maintenance Therapy with intravesical Bacillus Calmette-Guerin in Patients with intermediate- or High-risk Non-muscle-invasive Bladder Cancer) (2013)
  • Author(s): Muto S, Nakajima A, Horiuchi A, Inoue M, China T, Saito K, Isotani S, Hisasue S, Yamaguchi R, Ide H, Horie S.
  • Journal Title: Jpn J Clin Oncol. Volume: 43 Issue: 3 Pages: 305
  • DOI: 10.1093/jjco/hys225
  • Peer Reviewed
• [Journal Article] Interferon-α Treatment for Growing Teratoma Syndrome of the Testis. (2013)
  • Author(s): Inoue M, Hisasue S, Nagae M, China T, Saito K, Isotani S, Yamaguchi R, Ide H, Muto S, Horie S.
  • Journal Title: Case Rep Nephrol Urol. Volume: 10 Issue: 1 Pages: 40-45
  • DOI: 10.1159/000350897
  • Peer Reviewed
• [Journal Article] <b>Hochuekkito Efficacy in Late-Onset Hypogonadism (LOH) Patients </b> (2013)
  • Author(s): 熊本 友香, 久末 伸一, 安田 弥子, 井手 久満, 知名 俊幸, 井上 正浩, 斉藤 恵介, 磯谷 周治, 山口 雷蔵, 武藤 智, 堀江 重郎
  • Journal Title: Kampo Medicine Volume: 64 Issue: 3 Pages: 160-165
  • DOI: 10.3937/kampomed.64.160
  • NAID: 130003385089
  • ISSN: 0287-4857, 1882-756X
  • Peer Reviewed
• [Journal Article] Late onset hypogonadism(LOH)症候 群の概念と今後の展望 (2013)
  • Author(s): 久末 伸一, 堀江 重郎
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 36 Pages: 453-459
  • NAID: 40019700977
• [Journal Article] The Relationship Between Second-to-Fourth Digit Ratio and Female Gender Identity (2012)
  • Author(s): Hisasue S, Sasaki S, Tsukamoto T, Horie S
  • Journal Title: J Sex Med
  • Peer Reviewed
• [Journal Article] The impact of second-to-fourth digit ratio on the female gender identity. (2012)
  • Author(s): Hisasue, S. I., Sasaki, S., Tsukamoto, T., Horie, S.
  • Journal Title: Journal of Sexual Medicine Volume: 9(11) Issue: 11 Pages: 2903-2910
  • DOI: 10.1111/j.1743-6109.2012.02815.x
  • Peer Reviewed
• [Journal Article] Extranodal Rosai-Dorfman disease of the kidney and bone. (2012)
  • Author(s): Tabata H, Hisasue S, Tsukamoto T.
  • Journal Title: Int J Urol. Volume: 19 Issue: 5 Pages: 486-7
  • DOI: 10.1111/j.1442-2042.2011.02959.x
  • NAID: 10030755079
  • Peer Reviewed
• [Journal Article] The relationship between second-to-fourth digit ratio and female gender identity (2012)
  • Author(s): Shin-ichi Hisasue, Shoko Sasaki, Taiji Tsukamoto, Ph.D., Shigeo Horie
  • Journal Title: Journal of Sexual Medicine Volume: 未定
  • Peer Reviewed
• [Journal Article] 男性医学の25年 (2012)
  • Author(s): 久末 伸一、堀江 重郎
  • Journal Title: 泌尿器外科 Volume: 特別号 Pages: 608-611
• [Journal Article] Animal model for the study of the relationship between lower urinary tract symptoms/bladder outlet obstruction and erectile dysfunction (2011)
  • Author(s): Kobayashi K, Kato R, Hisasue S, Yamashita S, Tanaka T, Masumori N, et al
  • Journal Title: Int J Urol Volume: 18(10) Pages: 710-5
  • NAID: 10031164856
  • Peer Reviewed
• [Journal Article] Inhibition of interleukin-6 attenuates erectile dysfunction in a rat model of nerve-sparing radical prostatectomy (2011)
  • Author(s): Yamashita S, Kato R, Kobayashi K, Hisasue S, Arai Y, Tsukamoto T
  • Journal Title: J Sex Med Volume: 8(7) Pages: 1957-64
  • Peer Reviewed
• [Journal Article] 雌との共棲が加齢雄ラットのテストステロン値と勃起能に及ぼす影響 (2011)
  • Author(s): 金谷正秀,久末伸一,橋本浩平,伊藤志織里,松田洋平,塚本泰司
  • Journal Title: 日本性機能学会雑誌 Volume: 26(1) Pages: 7-14
  • NAID: 10029401454
  • Peer Reviewed
• [Journal Article] 雌との共棲が加齢雄ラットのテストステロン値に及ぼす影響 (2011)
  • Author(s): 金谷 正秀 , 久末 伸一 , 橋本 浩平 , 伊藤 志織里 , 松田 洋平 , 塚本 泰司
  • Journal Title: 日本性機能学会雑誌 Volume: 26(1) Pages: 7-14
  • Peer Reviewed
• [Presentation] Erectile Dysfunction and Prostate Cancer (2012)
  • Organizer: 2012年国際泌尿器科学会Société Inter nationale d'Urologie 2012
  • Place of Presentation: 福岡(Plenary Speaker)
  • Year and Date: 2012-10-04
• [Presentation] 『PDE5阻害剤無効例に対する対応-最新の知見を交えて-』勃起障害に対する低強度衝撃波治療の有効性 (2012)
  • Organizer: 第22回日本性機能学会中部総会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2012-08-04
• [Presentation] Initial experience of low energy shockwaves for the treatment of erectile dysfunction (2012)
  • Organizer: KSSMA 2012シンポジウム
  • Place of Presentation: 韓国
  • Year and Date: 2012-04-07
• [Presentation] 前立腺がんと性機能:QOLの向上を目ざして開腹と鏡視下手術:知っておくべき5つのこと (2012)
  • Organizer: 性機能学会東部総会イブニングセミナー
  • Place of Presentation: 千葉
  • Year and Date: 2012-02-17
• [Presentation] 前立腺癌治療後のED–前立腺全摘治療後のEDの対処を考える (2012)
  • Organizer: 第22回性機能学会西部総会ランチョンセミナー
  • Place of Presentation: 鹿児島
  • Year and Date: 2012-01-07
• [Presentation] アンドロロジーにおけるテストステロンの新展開 (2012)
  • Author(s): 久末伸一
  • Organizer: 関東アンドロロジーカンファレンス(招待講演)
  • Place of Presentation: 東京
• [Presentation] 前立腺がんと性機能：QOLの向上を目ざして 開腹と鏡視下手術：知っておくべき5つのこと (2012)
  • Author(s): 久末伸一、堀江重郎
  • Organizer: 東部性機能学会(招待講演)
  • Place of Presentation: 千葉
• [Presentation] 低強度体外衝撃波(ED1000)によるED治療の検討 (2012)
  • Author(s): 久末伸一、知名俊幸、磯谷周治、武藤 智、山口雷蔵、井手久満、堀江重郎
  • Organizer: 東部性機能学会
  • Place of Presentation: 千葉
• [Presentation] Higher age decrease the number of nNOS-positive ganglionic neuron around the prostate; decreased potential for collateral sprouting of cavernous nerve with age. (2011)
  • Author(s): Shin-ichi Hisasue, Kohei Hashimoto, Yohei Matsuda, Masahide Kanaya, Satoshi Takahashi, Taiji Tsukamoto
  • Organizer: 米国泌尿器科学会
  • Place of Presentation: Washington DC, USA
• [Presentation] THE IMPACT OF THE COHABITATION WITH FEMALES ON THE RECOVERY FROM THE ERECTILE DYSFUNCTION FOLLOWING CAVERNOUS NERVE INJURY IN RATS. (2011)
  • Author(s): Shin-ichi Hisasue, Kohei Hashimoto, Yohei Matsuda, Masahide Kanaya, Satoshi Takahashi, Taiji Tsukamoto
  • Organizer: 米国泌尿器科学会
  • Place of Presentation: Washington DC, USA
• [Presentation] Testosterone replacement alters the size of visceral fat cell but does not improve intracavernous pressure in aged male rats (2011)
  • Author(s): Shin-ichi Hisasue, Kohei Hashimoto, Yohei Matsuda, Masahide Kanaya, Satoshi Takahashi, Taiji Tsukamoto
  • Organizer: 米国泌尿器科学会
  • Place of Presentation: Washington DC, USA
• [Presentation] Initial experience of low energy shockwaves for the treatment of erectile dysfunction in Teikyo University Hospital, Japan (2011)
  • Author(s): Shin-ichi Hisasue, Hisamitsu Ide, Toshiyuki China, Satoru Muto, Raizo Yamaguchi, Shigeo Horie
  • Organizer: Men's Health World Congress
  • Place of Presentation: Vienna, Austria
• [Presentation] 外来受診患者における第2手指/第4手指の指長比と性ホルモン値の関連 (2011)
  • Author(s): 久末伸一、井手久満、磯谷周治、知名俊幸、永栄美香、吉井 隆、小関達郎、常盤紫野、斉藤恵介、武藤 智、山口雷蔵、堀江重郎
  • Organizer: テストステロン研究会
  • Place of Presentation: 福岡
• [Presentation] テレビ放送前後における帝京大学泌尿器科メンズヘルス外来受診患者背景の検討 (2011)
  • Author(s): 久末伸一、井手久満、吉井 隆、知名俊幸、磯谷周治、斉藤恵介、小関達郎、常盤紫野、永栄美香、山口雷蔵、武藤 智、堀江重郎
  • Organizer: 日本性機能学会
  • Place of Presentation: 倉敷
• [Presentation] 低強度体外衝撃波(ED1000)によるED治療の可能性 (2011)
  • Author(s): 久末伸一
  • Organizer: 西日本泌尿器科学会(招待講演)
  • Place of Presentation: 福岡
• [Presentation] Treatment of Erectile Dysfunction (2011)
  • Author(s): Shin-ichi Hisasue
  • Organizer: Korea-Japan Urological meeting(招待講演)
  • Place of Presentation: ソウル、韓国
• [Presentation] 超音波を用いた腎・泌尿器領域の各臓器血 流測定とその意義 陰茎海綿体血流と勃起機能
  • Author(s): 久末伸一
  • Organizer: 日本超音波医学会第 86 回学術集会パネルディスカッション
  • Place of Presentation: 大阪
  • Invited
• [Presentation] ドライシンドロームの基礎と臨床 ドライシンドロ ームとテストステロン
  • Author(s): 久末伸一
  • Organizer: 第 13 回日本抗加齢医学会総会 シンポジウム)
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 男性力ドックの試み
  • Author(s): 久末伸一
  • Organizer: 第 13 回日本抗加齢医学会総会 ランチョンセミナー
  • Place of Presentation: 横浜
  • Invited
• [Presentation] ED に対する低強度体外衝撃波治療と未来の治療戦略
  • Author(s): 久末伸一
  • Organizer: 第 101 回泌尿器科学会総会パネルディスカッション
  • Place of Presentation: 札幌
  • Invited
• [Presentation] The low-intensity shock wave therapy for erectile dysfunction: Who needs it? Who benefits from it?
  • Author(s): Shin-ichi Hisasue
  • Organizer: The 8th Japan-ASEAN Conference on Men’s Health and Aging
  • Place of Presentation: 軽井沢
  • Invited
• [Presentation] The actual practice of ED medical examination in Asia－based on Guidelines－
  • Author(s): Shin-ichi Hisasue, Shigeo Horie
  • Organizer: The 8th Japan-ASEAN Conference on Men’s Health and Aging
  • Place of Presentation: 軽井沢
  • Invited
• [Presentation] 女性の情緒・行動に及ぼすAndrogenの作用
  • Author(s): 久末伸一、堀江重郎
  • Organizer: テストステロン研究会
  • Place of Presentation: 軽井沢
  • Invited
• [Presentation] The efficacy and feasibility of low-intensity shock wave therapy for erectile dysfunction in Japanese patients
  • Author(s): Shin-ichi Hisasue, Shigeo Horie
  • Organizer: 14th Asia-Pacific Society for Sexual Medicine
  • Place of Presentation: 金沢
  • Invited
• [Presentation] Initial experience of low-intensity shock wave therapy for the ED patients in Japan
  • Author(s): Shin-ichi Hisasue, Toshiyuki China, Hisamitsu Ide, Masahiro Inoue, Takashi Yosii, Keisuke Saito, Shuji Isotani, Satoru Muto, Raizo Yamaguchi, Shigeo Horie
  • Organizer: 国際性機能学会
  • Place of Presentation: 米国 シカゴ
• [Presentation] 世界と日本：ネットワークの貢献
  • Author(s): 久末伸一
  • Organizer: 日本性機能学会第23回学術総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 勃起障害に対する低強度体外衝撃波の治療効果予測因子の検討
  • Author(s): 久末伸一、知名俊幸、磯谷周治、武藤 智、山口雷蔵、井手久満、堀江重郎
  • Organizer: 日本性機能学会第23回学術総会
  • Place of Presentation: 東京
• [Presentation] Aging Males' Symptoms (AMS) スコアとSF36v2による生活の質との関連の検討
  • Author(s): 久末伸一、井手久満、吉井 隆、知名俊幸、磯谷周治、斉藤恵介、小関達郎、常盤紫野、永栄美香、山口雷蔵、武藤 智、堀江重郎
  • Organizer: 日本泌尿器科学会総会
  • Place of Presentation: 横浜