| Project/Area Number |
23592382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
UMEMOTO Yukihiro 名古屋市立大学, 医学(系)研究科(研究院), 講師 (80381812)
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| Co-Investigator(Kenkyū-buntansha) |
KOHRI Kenjiro 名古屋市立大学, 大学院医学研究科, 教授 (30122047)
SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 准教授 (50225869)
KUBOTA Hiroki 名古屋市立大学, 大学院医学研究科, 研究員 (10347403)
MIZUNO Kentaro 名古屋市立大学, 大学院医学研究科, 講師 (70448710)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | Numb / Numb-like / 造精機能障害 / 男性不妊症モデル / 停留精巣 / siRNA / Fem1b / 男性不妊症モデルマウス |
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| Research Abstract |
Notch signaling pathway plays a key role in gametogenesis in nematodes by maintaining proliferative ability of spermatogenic stem cells.
Our result showed that a relative ratio of Numb and Nbl expression might play a role in differentiation of germ cells in rat testes. This is analogous to regulation of Notch signaling pathway and development of the central nervous system. Our gene knock-down experiment suggested that Numb and Nbl have essential roles in the regulation of germ cell differentiation after meiotic phase (spermatocytes or spermatids). Suppressing the Notch signaling pathway by disrupting Numb/Nbl may induce germ cell differentiation in the testes of patients with male infertility.
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