• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on new sperm laboratory procedure for appropriate treatment options in the assisted reproductive technology

Research Project

Project/Area Number 23592383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionInternational University of Health and Welfare

Principal Investigator

IWAMOTO Teruaki  国際医療福祉大学, 大学病院, 教授 (60046117)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Kaoru  桐蔭横浜大学, 先端医用工学センター, 講師 (70398973)
YOSHIIKE Miki  聖マリアンナ医科大学, 医学部, 研究技術員 (60398964)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords精子運動抑制因子 / セメノジェリン / 精子無力症 / 精液検査 / 男性不妊症 / 精嚢蛋白 / 妊孕能 / 少子化 / 妊孕性 / semenogelin
Research Abstract

Half of infertile couples are caused by a male factor. However, the most of the cause are unknown. Therefore, it is forced to use current state assisted reproductive technology (ART). Research delegates worked on the development of new tests that can diagnose the fertility of sperm for the treatment decision-in addition to a conventional semen analysis (sperm concentration, motility and morphology). Semenogelin (Sg), seminal vesicle protein is one of the causes of asthenozoospermia.Therefore, Sg binding rate and the amount of binding to the sperm of male infertility patients and partners of fertile women as control were measured. As a result, it was revealed that these parameters were significantly higher in former cases than in latter. In the future, it is necessary to clarify association with the relevance pregnancy rate and the birth rate of infertile couple whether the measurements of Sg binding to male infertile patient's sperm can be a new method for semen analysis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (12 results)

  • [Journal Article] Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men2014

    • Author(s)
      Sato Y, Iwamoto T, Shinka T, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Yamauchi A, Nakahori Y
    • Journal Title

      Biol Reprod

      Volume: 90(6)(Epub 2014 Apr 23) Issue: 6 Pages: 116-116

    • DOI

      10.1095/biolreprod.114.118810

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pyrethroid insecticide exposure and semen quality of young Japanese men2014

    • Author(s)
      Imai K, Yoshinaga J, Yoshikane M, Shiraishi H, Mieno MN, Yoshiike M, Nozawa S, Iwamoto T.
    • Journal Title

      Reprod Toxicol.

      Volume: 43: Pages: 38-44

    • DOI

      10.1016/j.reprotox.2013.10.010

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semen quality of 1559 young men from2014

    • Author(s)
      Teruaki Iwamoto,Shiari Nozawa, Makiko Naka Mieno, Katsunori Yamakawa, Katsuyuki Baba, Miki Yoshiike, Mikio Namiki, Eitetsu Koh,Jiro Kanaya, Akihiko Okuyama, Kiyomi Matsumiya, Akira Tsujimura, Hiroshi Kanetake, Jiro Eguchi, Niels E Skakkebaek, Matti Vierula, Jorma Toppari, Niels Jørgensen
    • Journal Title

      BMJ Open

      Volume: 3 Issue: 4 Pages: e002222-e002222

    • DOI

      10.1136/bmjopen-2012-002222

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺肥大症治療薬であるエビプロスタットの造精機能障害に対する有効性ーカルナクリンを対照薬とした、ランダム化、オープン並行群間比較試験ー2014

    • Author(s)
      岩本晃明、山崎一恭、三重野牧子、平野泰子、古井久仁子、室井美樹、唐松美佳、圓成寺真美、高見澤聡、柳田薫
    • Journal Title

      日受着学会誌

      Volume: 31 Pages: 42-50

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semen quality of 1559 young men from four cities in Japan : a cross-sectional population-based study2013

    • Author(s)
      T Iwamoto,S Nozawa,MN Mieno,K Yamakawa,K Baba, M Yoshiike, M Namiki, E Koh, J Kanaya,A Okuyama, K Matsumiya, A Tsujimura, H Kanetake,J Eguchi, NE Skakkebaek, M Vierula,J Toppari, N Jorgensen
    • Journal Title

      bmjopen

      Volume: (bmj.com on April 30, 2013 -Published by group.bmj.com)

    • NAID

      120006985858

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semen quality of fertile Japanese men : a cross-sectional population-based study of 792 men2013

    • Author(s)
      T Iwamoto, S Nozawa,M Yoshiike,M Namiki, E Koh,J Kanaya, A Okuyama, K Matsumiya,A Tsujimura,K Komatsu, T Tsukamoto,N Itoh, MN Mieno.M Vierula,J Toppari, NE Skakkebak, N Jorgensen
    • Journal Title

      bmjopen

      Volume: (bmj.com onJanuary 31, 2013 - Published bygroup.bmj.com)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Y chromosome haplogroup D2* lineage is associated with azoospermia in Japanese males2013

    • Author(s)
      Youichi Sato, Toshikatsu Shinka, Teruaki Iwamoto, Aiko Yamauchi and Yutaka Nakahori
    • Journal Title

      Biology of Reproduction

      Volume: Vol.88, No.4 Issue: 4 Pages: 107-107

    • DOI

      10.1095/biolreprod.112.105718

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of adult mouse sertoli cell lines by using starvation method2013

    • Author(s)
      Y Sato, K Yoshida, S Nozawa,MYoshiike, M Arai, T Otoi, and T Iwamoto
    • Journal Title

      Reproduction

      Volume: (REP-12-0086 Reproduction Advance Publication first posted online on 18 March 2013)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication Study and Meta-Analysis of Human Non-Obstructive Azoospermia in Japanese Populations2013

    • Author(s)
      Sato Y, Jinam T, Iwamoto T, Yamauchi A, Imoto I, Inoue I, Tajima A
    • Volume
      (Epub ahead of print)
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 男性性腺機能低下症2013

    • Author(s)
      山崎一恭、西山博之、岩本晃明
    • Journal Title

      Medicina10号

      Volume: 50巻 Pages: 1828-1831

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Climatic influence on the reproductive characteristics of Japanese males2012

    • Author(s)
      Nakahori Y,Sato Y, Ewis AA, Iwamoto T, Shinka T, Nozawa S,Yoshiike M, Yang XJ, Sei M,Namiki M,Koh E,Ito N, Matsumiya K, Nakagome Y
    • Journal Title

      J Hum Genet

      Volume: 57(6)(Epub 2012 Apr 26) Issue: 6 Pages: 375-8

    • DOI

      10.1038/jhg.2012.38

    • NAID

      10030808079

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel Y chromosome microdeletion with the loss of an endogenous retrovirus (ERV)-related testis-specific transcript in AZFb region2011

    • Author(s)
      Sin HS, Koh E, Taya M, IIjima M, Sugimoto K, Maeda Y, Yoshida A, Iwamoto T, Namiki M
    • Journal Title

      J Urol

      Volume: 186(4) Pages: 1545-52

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム7高齢不妊カップルに対する治療戦略加齢が精子の質/男性生殖機能に及ぼす影響~射出精子の質の向上を目指して~2013

    • Author(s)
      山崎一恭、西山博之、岩本晃明
    • Organizer
      第58日本生殖医学会学術講演会・総会
    • Place of Presentation
      神戸
    • Year and Date
      2013-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 精漿タンパク質SEMGの精子の受精能評価マーカーとしての検討2013

    • Author(s)
      吉田薫、山崎一恭、吉池美紀、岩本晃明
    • Organizer
      第58回 日本生殖医学会 学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 精嚢分泌タンパクSVS2のマウス体内受精における役割について2011

    • Author(s)
      河野菜摘子、荒木直也、吉田薫、吉田学、宮戸健二
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 両側精索静脈瘤に対して腹腔鏡下内精索静脈結紮術を施行し、精子運動率の著明な改善を得た高度精子無力症の1例2011

    • Author(s)
      山崎一恭、菅藤哲、高見澤聡、藤倉洋子、室井美樹、柳田薫、岩本晃明
    • Organizer
      第76回日本泌尿器科学会東部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 精嚢分泌タンパクSVS2のマウス体内受精における役割について2011

    • Author(s)
      河野菜摘子、荒木直也、吉田薫、吉田学、宮戸健二
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-23
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 精管精巣上体管吻合術後47日目に射出精子の出現を見た閉塞性無精子症の一例2011

    • Author(s)
      松下知彦、長谷川太郎、中野勝、岩本晃明
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 両側精索静脈瘤に対して腹腔鏡下内精索静脈結紮術を施行し、精子運動率の著明な改善を得た高度精子無力症の1例2011

    • Author(s)
      山崎一恭、菅藤哲 、高見澤聡 、藤倉洋子 、室井美樹 、柳田薫 、岩本晃明
    • Organizer
      144回日本生殖医学会関東地方部会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 国際医療福祉大学病院リプロダクションセンター男性不妊部門開設後4年の手術統計2011

    • Author(s)
      山崎一恭、菅藤哲、寺井一隆、松下知彦、石塚竜太郎、稲井広夢、内田克紀、高見澤聡、柳田薫、岩本晃明
    • Organizer
      第76回日本泌尿器科学会東部総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 精管精巣上体管吻合術後47日目に射出精子の出現を見た閉塞性無精子症の一例2011

    • Author(s)
      松下知彦、長谷川太郎、中野勝、岩本晃明
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス精子受精能獲得における精嚢分泌タンパク質SVSsの機能解析2011

    • Author(s)
      荒木直也 吉田薫 河野菜摘子 宮戸健二 吉田学
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] インジゴカルミン精巣内注入によるリンパ管温存精索静脈瘤根治術の有用性につ いて

    • Author(s)
      山崎一恭、菅藤哲、福崎篤、遠藤 剛、稲井広夢、内田克紀、 石橋広樹、大塩猛人、森川康英、岩本晃明
    • Organizer
      第101回 日本泌尿器科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] シンポジウム7 高齢不妊カップルに対する治療戦略。加齢が精子の質/男性生殖機能に及ぼす影響

    • Author(s)
      山崎一恭、西山博之、岩本晃明
    • Organizer
      第58回 日本生殖医学会 学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi