Study on new sperm laboratory procedure for appropriate treatment options in the assisted reproductive technology
Project/Area Number |
23592383
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | International University of Health and Welfare |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kaoru 桐蔭横浜大学, 先端医用工学センター, 講師 (70398973)
YOSHIIKE Miki 聖マリアンナ医科大学, 医学部, 研究技術員 (60398964)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 精子運動抑制因子 / セメノジェリン / 精子無力症 / 精液検査 / 男性不妊症 / 精嚢蛋白 / 妊孕能 / 少子化 / 妊孕性 / semenogelin |
Research Abstract |
Half of infertile couples are caused by a male factor. However, the most of the cause are unknown. Therefore, it is forced to use current state assisted reproductive technology (ART). Research delegates worked on the development of new tests that can diagnose the fertility of sperm for the treatment decision-in addition to a conventional semen analysis (sperm concentration, motility and morphology). Semenogelin (Sg), seminal vesicle protein is one of the causes of asthenozoospermia.Therefore, Sg binding rate and the amount of binding to the sperm of male infertility patients and partners of fertile women as control were measured. As a result, it was revealed that these parameters were significantly higher in former cases than in latter. In the future, it is necessary to clarify association with the relevance pregnancy rate and the birth rate of infertile couple whether the measurements of Sg binding to male infertile patient's sperm can be a new method for semen analysis.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men2014
Author(s)
Sato Y, Iwamoto T, Shinka T, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Yamauchi A, Nakahori Y
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Journal Title
Biol Reprod
Volume: 90(6)(Epub 2014 Apr 23)
Issue: 6
Pages: 116-116
DOI
Related Report
Peer Reviewed
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[Journal Article] Semen quality of 1559 young men from2014
Author(s)
Teruaki Iwamoto,Shiari Nozawa, Makiko Naka Mieno, Katsunori Yamakawa, Katsuyuki Baba, Miki Yoshiike, Mikio Namiki, Eitetsu Koh,Jiro Kanaya, Akihiko Okuyama, Kiyomi Matsumiya, Akira Tsujimura, Hiroshi Kanetake, Jiro Eguchi, Niels E Skakkebaek, Matti Vierula, Jorma Toppari, Niels Jørgensen
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Journal Title
BMJ Open
Volume: 3
Issue: 4
Pages: e002222-e002222
DOI
Related Report
Peer Reviewed
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[Journal Article] Semen quality of 1559 young men from four cities in Japan : a cross-sectional population-based study2013
Author(s)
T Iwamoto,S Nozawa,MN Mieno,K Yamakawa,K Baba, M Yoshiike, M Namiki, E Koh, J Kanaya,A Okuyama, K Matsumiya, A Tsujimura, H Kanetake,J Eguchi, NE Skakkebaek, M Vierula,J Toppari, N Jorgensen
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Journal Title
bmjopen
Volume: (bmj.com on April 30, 2013 -Published by group.bmj.com)
NAID
Related Report
Peer Reviewed
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[Journal Article] Semen quality of fertile Japanese men : a cross-sectional population-based study of 792 men2013
Author(s)
T Iwamoto, S Nozawa,M Yoshiike,M Namiki, E Koh,J Kanaya, A Okuyama, K Matsumiya,A Tsujimura,K Komatsu, T Tsukamoto,N Itoh, MN Mieno.M Vierula,J Toppari, NE Skakkebak, N Jorgensen
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Journal Title
bmjopen
Volume: (bmj.com onJanuary 31, 2013 - Published bygroup.bmj.com)
Related Report
Peer Reviewed
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[Journal Article] Climatic influence on the reproductive characteristics of Japanese males2012
Author(s)
Nakahori Y,Sato Y, Ewis AA, Iwamoto T, Shinka T, Nozawa S,Yoshiike M, Yang XJ, Sei M,Namiki M,Koh E,Ito N, Matsumiya K, Nakagome Y
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Journal Title
J Hum Genet
Volume: 57(6)(Epub 2012 Apr 26)
Issue: 6
Pages: 375-8
DOI
NAID
Related Report
Peer Reviewed
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