| Project/Area Number |
23592384
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
ISHIDA Hideki 東京女子医科大学, 医学部, 臨床教授 (60246543)
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| Co-Investigator(Kenkyū-buntansha) |
TANABE Kazunari 東京女子医科大学, 医学部, 教授 (80188359)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 腎移植 / 血液型不適合 / 抗体 / カイメリズム / 抗体拒絶反応 / 抗体関与 / 慢性拒絶反応 / 血管キメラ / 腎臓移植 / 長期生着 / 免疫寛容 / 血管キメリズム / 血液型抗原 / 抗体型拒絶反応 / キメラ |
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| Outline of Final Research Achievements |
Endothelial chimerism in transplanted organs can be defined as the presence of recipient-derived endothelial cells in the donor organ. First, we investigated the presence of chimerism in renal allografts of ABO-incompatible kidney transplantation recipients. Second, we analyzed the association between chimerism and the clinical course. We investigated the presence of chimerism in renal allografts of ABO-incompatible kidney transplantation recipients by immunohistochemical detection of blood type A and B antigens and assessed the association between chimerism and the clinical course. Twelve of the 49 patients (24.5%) exhibited endothelium chimerism in a biopsy sample. Among the 12 patients with endothelium chimerism, 7 patients ( 59%) had acute and chronic active antibody-mediated rejection. The graft survival rate in the chimerism group was significantly lower than that in the no-chimerism group. Endothelial chimerism appears to be a hallmark of vigorous immune or non-immune responses.
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