| Project/Area Number |
23592385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Fujita Health University |
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Principal Investigator |
KUSAKA Mamoru 藤田保健衛生大学, 医学部, 教授 (40309141)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHINAGA Kiyotaka 藤田保健衛生大学, 医学部, 教授 (30229174)
SHIROKI Ryoichi 藤田保健衛生大学, 医学部, 教授 (70226330)
KAWAI Akihiro 藤田保健衛生大学, 医学部, 助手 (00617144)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腎移植 / バイオマーカー / 循環器合併症 / 心機能 / 移植腎機能 / 献腎移植 / 移植腎予後 / 虚血再潅流障害 |
|---|
| Research Abstract |
This study evaluated the usefulness of serum NGAL, L-FABP and HMGB-1 as potential biomarkers to predict early graft functional recovery of transplanted kidneys from donors after cardiac death(DCD). From our results suggested that serial monitoring of serum NGAL, L-FABP and HMGB-1 may predict graft recovery and the need for hemodialysis after a kidney transplantation from DCD.
Cardiovascular morbidity and mortality are highly prevalent in kidney transplant recipients. Troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are well known maker of cardiac dysfunction and is a strong predictor of mortality in dialysis patients. We evaluated the serum Troponin T and NT-proBNP as predictive biomarkers for the adverse cardiac events after KTx from DCD. From our results suggested that serial analysis of sTroponin T and sNT-proBNP, even though under the influence of graft recovery, may predict adverse cardiac events after kidney transplantation from DCD .
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