| Project/Area Number |
23592389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hirosaki University |
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Principal Investigator |
ITO Asami 弘前大学, 医学(系)研究科(研究院), 研究員 (30536511)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Kanji 弘前大学, 医学部付属病院, 准教授 (20311540)
KAKIZAKI Ikuko 弘前大学, 医学(系)研究科, 准教授 (80302024)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 切迫早産 / 子宮頸管無力症 / ヒアルロン酸 / 4-methylumbelliferone / プロゲステロン |
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| Research Abstract |
Hyaluronate is a main component of the uterine cervix. Rapid increase of hyaluronate affects ripening and dilatation of the uterine cervix, and delivery is performed quickly. Therefore, it can be the medical treatment of preventing premature labor to inhibit the synthesis of hyaluronate. I researched about the fundamental study of 4-methylumbelliferone (MU), and the possibility of controlling cervical ripening. In the cultured fibroblasts from human uterine cervix, the effects of MU were evaluated by the suppression of hyaluronate synthesis, and it suppressed dependently by a concentration. Moreover, in the rat models of preterm labor, MU subcutaneous continuous infusion cannot significantly extend their gestational age. Although the usefulness of MU was shown in the cultured fibroblasts from human uterine cervix, clinical application requires examination of an administration route (a vagina suppository and taking orally).
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