Physiological and pathological roles of lipid immune mediators in pregnancy

• Project/Area Number: 23592394
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: FUJII TOMOYUKI 東京大学, 医学部附属病院, 教授 (40209010)
• Co-Investigator(Kenkyū-buntansha): KAWANA Kei 東京大学, 医学部附属病院, 准教授 (60311627)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脂質メディエーター / リゾフォスファチジン酸 / オートタキシン / 妊娠 / 胎盤 / オメガ３脂肪酸 / 妊娠高血圧症候群 / 早産 / リゾリン酸 / 脂質メディエータ / オメガ６脂肪酸 / 炎症 / マクロファージ / 動物実験

Research Abstract

We investigated the roles of autotaxin (ATX)/lysophosphatidic acid (LPA) system and omega3/omega6 fatty acids system during pregnancy. AS for ATX/LPA system, both ATX and LPA concentrations in maternal blood increased along with the weeks of gestation. Placental trophoblasts expressed LPA3, a receptor for LPA. Expression of ATX in placenta decreased in pregnancy-induced hypertension compared to normal pregnancy. A specific agonist for LPA3 enhanced the expression of cyclooxygenase2 in trophoblasts. As for omega3/omega6 fatty acids system, abundance of omega3 fatty acids reduced the incidence of preterm birth in mice model. In those mice, inflammation in the uterus was suppressed and high level of metabolites in omega3 fatty acids system was observed. The intravenous injection of resolvin to LPS exposed pregnant wild type mice lowered the incidence of preterm birth

Research Products

• [Journal Article] Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth (2013)
  • Author(s): Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Arimoto T, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Kozuma S, Arai H, Arita M, Osuga Y, Fujii T
  • Journal Title: Sci Rep Volume: 3 Pages: 3113-3113
  • Peer Reviewed
• [Journal Article] Increased tissue level of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. (2013)
  • Author(s): Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 3113-3113
  • DOI: 10.1038/srep03113
  • Peer Reviewed
• [Presentation] リゾフォスファチジン酸系は絨毛細胞における血管新生関連因子の発現を誘導するー妊娠高血圧症候群の病因の解明にむけてー (2014)
  • Author(s): 市川麻佑子、永松健、山下隆博、板岡奈央、佐山晴亮、河合有希、川名敬、大須賀穣、藤井知行
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
• [Presentation] EPA(エイコペンタエン酸)の活性代謝物は新規の早産予防薬になりうる (2013)
  • Author(s): 山下亜紀、川名敬、有田誠、田口歩、古屋仁美、冨尾賢介、長阪一憲、永松健、織田克利、矢野哲、藤井知行、上妻志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 正常妊娠における母体血中LPA濃度の推移と妊娠高血圧症候群における胎盤のATX発現量の評価 (2013)
  • Author(s): 市川麻佑子、山下隆博、永松健、板岡奈央、佐山晴亮、川名敬、藤井知行、上妻志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] EPA（エイコペンタエン酸）の活性代謝物は新規の早産予防薬になりうる (2013)
  • Author(s): 山下亜紀、川名敬、有田誠、田口歩、古屋仁美、冨尾賢介、長阪一憲、永松健、織田克利、矢野哲、藤井知行、上妻志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] オメガ3脂肪酸(EPA, DHA等)による早産予防効果とその機序に関する研究 (2012)
  • Author(s): 山下亜紀、川名敬、冨尾賢介、田口歩、小島聡子、佐山晴亮、永松健、織田克利、山下隆博、藤井知行、上妻志郎、武谷雄二
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] オメガ３脂肪酸(EPA, DHA等)による早産予防効果とその機序に関する研究 (2012)
  • Author(s): 山下亜紀、川名敬、冨尾賢介、田口歩、小島聡子、佐山晴亮、永松健、織田克利、山下隆博、藤井知行、上妻志郎、武谷雄二
  • Organizer: 日本産科婦人科学会第６４回学術講演会
  • Place of Presentation: 神戸市