Research Project
Grant-in-Aid for Scientific Research (C)
Endometriosis is a chronic inflammatory disease in which the Th2 immune response is activated and has been suggested to promote the disease. TSLP is a master cytokine that drive Th2 immune response.IL-1b stimulated the expression of TSLP mRNA and secretion of TSLP protein from ESCs. IL-4 enhanced the IL-1b-induced TSLP secretion from ESCs, while IFNg reduced it. Inhibitors of p42/44 MAPK, p38 MAPK and SAPK/JNK suppressed the IL-1b-induced secretion of TSLP from ESCs. Positive immunostaining of TSLP was observed in the stroma of endometrioma tissue. TSLP concentrations in the serum and PF were both higher in women with endometriosis compared with those without endometriosis.This study provided new insights in the Th2 immune response-related mechanism in endometriosis.
All 2014 2013 2012 2011 Other
All Journal Article (21 results) (of which Peer Reviewed: 17 results) Presentation (9 results) (of which Invited: 1 results) Book (3 results) Remarks (1 results)
J Obstet Gynaecol Res
Volume: 40 Issue: 3 Pages: 770-8
10.1111/jog.12252
Volume: 40 Issue: 1 Pages: 40-5
10.1111/jog.12118
Volume: (Epub ahead of print) Issue: 2 Pages: 495-500
10.1111/jog.12189
Int J Womens Health
Volume: 6 Pages: 11-23
10.2147/ijwh.s52429
PLoS One
Volume: 8 Issue: 9 Pages: 2013-2013
10.1371/journal.pone.0073085
J Clin Endocrinol Metab
Volume: 98(4) Issue: 4 Pages: 1583-90
10.1210/jc.2012-3475
Reprod Sci
Volume: 20(6) Issue: 6 Pages: 675-9
10.1177/1933719112463253
Gynecological Endocrinology
Volume: 29 Issue: 2 Pages: 113-115
10.3109/09513590.2012.706669
(第10章)性ホルモン関連エストロゲン・プロゲステロン.内分泌・糖尿病・代謝内科(1884-2917)
Volume: 36巻Suppl Pages: 345-351
手術療法チョコレート嚢胞産婦人科の実際(0558-4728)
Volume: 62巻5号 Pages: 651-657
Fertil Steril
Volume: 98 Issue: 5 Pages: 1218-24
10.1016/j.fertnstert.2012.07.1117
Hum Reprod
Volume: 27 Issue: 10 Pages: 3028-35
10.1093/humrep/des291
Front Biosci (Schol Ed)
Volume: Review Pages: 1201-12
http://www.ncbi.nlm.nih.gov/pubmed/22652866
Eur J Obstet Gynecol Reprod Biol
Volume: 162(1) Issue: 1 Pages: 87-90
10.1016/j.ejogrb.2012.01.018
子宮内膜症子宮内膜症の病態の新たな側面. HORMONE FRONTIER IN GYNECOLOGY
Volume: 19巻4号 Pages: 291-296
日本産科婦人科学会雑誌
Volume: 64巻1号 Pages: 105-111
110008913810
Volume: 96(1) Issue: 1 Pages: 118-21
10.1016/j.fertnstert.2011.05.006
Volume: 96(1) Issue: 1 Pages: 113-7
10.1016/j.fertnstert.2011.04.060
Volume: 26(7) Issue: 7 Pages: 1892-8
10.1093/humrep/der125
Gynecol Endocrinol
Volume: 27(9) Issue: 9 Pages: 717-20
10.3109/09513590.2010.533800
Volume: 96 Pages: 113-117
http://square.umin.ac.jp/tkyobgyn/