The development of fertility treatment for patients with premature ovarian failure or diminished ovarian reserve by regulating activin action.
| Project/Area Number |
23592400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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|---|
| Keywords | 早発卵巣不全 / 原始卵胞活性化 / アクチビン / 黄体ホルモン / 原始卵胞 / 休眠原始卵胞 |
|---|
| Research Abstract |
Mouse neonatal ovaries of day 5.5 were cultured with or without progestin for 48 hours. We found the Activin beta A and beta B mRNA expression was decreased to half. Based on the fact we researched the effect of continuous progestin exposure to mouse ovarian function. Five mg of dienogest solved in corn oil or corn oil was given by intraperitoneal injection to sixteen week old mice every four days. After sixteen times injection the mice were housed with male mice. The total numbers of pups born from a mouse were compared. It was greater in dienogest group (P < 0.03). The last delivery age was also higher in dienogest group. We speculate that dienogest suppressed primordial follicle activation and maintained the primordial follicle pool through the suppression of activin action. This result would be applicable for the maintenance of ovarian reserve and fertility in the developed country including Japan, where women get married in older age. Now we investigate this progestin effect.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] 子宮腺筋症の月経中の凝固線溶系の解析2012
Author(s)
木村 文則, 山中 章義, 高橋 顕雅, 竹林 明枝, 高島 明子, 天野 創, 清水 良彦, 中川 哲也, 喜多 伸幸, 高橋 健太郎, 村上 節
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Journal Title
エンドメトリオーシス学会会誌
Volume: 33
Pages: 145-148
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[Journal Article] 子宮内膜症性疼痛に対する治療2011
Author(s)
木村文則, 脇ノ上史朗, 山中章義, 高橋顕雅, 竹林明枝, 高島明子, 清水良彦, 中川哲也, 喜多伸幸, 村上節, 高橋健太郎
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Journal Title
滋賀県産科婦人科雑誌
Volume: 3
Pages: 5-12
NAID
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Peer Reviewed
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[Presentation] 妊娠中の卵巣腫瘍に対し単孔式アプローチを用いて腹腔鏡下卵巣腫瘍核出術を施行した3症例2011
Author(s)
高島明子,脇ノ上史朗, 清水良彦, 山中章義, 竹林明枝, 齊藤真理, 天野創, 辻俊一郎, 井上貴至, 木村文則, 喜多伸幸, 高橋健太郎, 村上節
Organizer
第51回日本産科婦人科内視鏡学会
Place of Presentation
大阪 大阪国際会議場
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