A trial of the establishment of the umbilical cord blood stem cell transplantation for the neonatal brain injury: a search for the effective transplantation -
Project/Area Number |
23592402
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Osaka University |
Principal Investigator |
KANAGAWA Takeshi 大阪大学, 医学(系)研究科(研究院), 助教 (40346218)
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Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Yukiko 大阪大学, 医学系研究科, 助教 (60423175)
MIMURA Kazuya 大阪大学, 医学系研究科, 助教 (50437422)
TOMIMATSU Takuji 川崎医科大学, 医学部, 准教授 (30346209)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 新生児低酸素虚血性脳障害 / 胎児付属物 / 幹細胞 / カフェイン / NF-κB / プレコンディショニング / 新生児低酸素性虚血性脳障害 / 神経再生 / 間葉系幹細胞 / preconditioning / IMD-0354 / 1.新生児低酸素性虚血性脳障害 / HIF-1α |
Research Abstract |
The Perinatal brain damage due to the fetal distress or neonatal distress remains the most important problem although the perinatal care develops rapidly remarkably. The aims of this research are the decrease the perinatal damage.In this research,we discovered that the short-term treatment of caffeine induced the neuroprotection which is attributed from the activation of NF-kappaB.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Hypoxic preconditioning increases triiodothyronine (T3) level in the developing rat brain2013
Author(s)
Minato K, Tomimatsu T, Mimura K, Jugder O, Kakigano A, Kanayama T, Fujita S, Taniguchi Y, Kanagawa T, Endo M, Kimura T
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Journal Title
Brain Res
Volume: 1501
Pages: 89-97
Related Report
Peer Reviewed
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[Journal Article] Disease flare-ups and obstetric outcomes in pregnant women with systemic lupus erythematosus2013
Author(s)
Takahashi, K. Mimura, K. Kanagawa, T. Kinugasa-Taniguchi, Y. Endo, M. Matsuzaki, S. Kumasawa, K. Hashimoto, K. Tomimatsu, T. Kimura, T.
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Journal Title
Hypertens Res Pregnancy
Volume: 2
Pages: 1-5
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice.2013
Author(s)
Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I.
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Journal Title
J Reprod Immunol.
Volume: 100(2)
Issue: 2
Pages: 118-127
DOI
Related Report
Peer Reviewed
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[Journal Article] Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report2013
Author(s)
Kakigano, A. Mimura, K. Kanagawa, T. Nakayama, M. Kanayama, T. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
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Journal Title
Placenta
Volume: 34
Issue: 7
Pages: 628-630
DOI
Related Report
Peer Reviewed
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[Journal Article] The prognostic factors and the outcome of primary isolated fetal ascites.2011
Author(s)
Nose S, Usui N, Soh H, Kamiyama M, Tani G, Kanagawa T, Kimura T, Arahori H, Nose K, Kubota A, Fukuzawa M.
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Journal Title
Pediatr Surg Int.
Volume: 27
Pages: 799-804
Related Report
Peer Reviewed
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[Journal Article] Effects of 4-hydroxy-2-nonenal, a major lipid peroxidation-derived aldehyde, and N-acetylcysteine on the cyclooxygenase-2 expression in human uterine myometrium.2011
Author(s)
Temma-Asano K, Tskitishvili E, Kanagawa T, Tomimatsu T, Tsutsui T, Kimura T, Chang YS, Nakamura T, Nakai Y, Shimoya K.
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Journal Title
Gynecol Obstet Invest.
Volume: 72
Pages: 37-42
Related Report
Peer Reviewed
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[Journal Article]
Author(s)
Tomimatsu T, Kakigano A, Mimura K, Kanayama T, Koyama S, Fujita S, Taniguchi Y, Kanagawa T, Kimura T
Related Report
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[Presentation] 新生児GBS感染症予防対策は新生児大腸菌保有率を上昇させるか2012
Author(s)
藤田 聡子, 金川 武司, 石井 貴子, 脇本 哲, 柿ヶ野 藍子, 金山 智子, 湊 健志, 味村 和哉, 谷口 友基子, 冨松 拓治, 木村 正
Organizer
日本産科婦人科学会
Place of Presentation
兵庫
Related Report
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[Presentation] 発作性夜間血色素尿症合併妊娠の1例.2012
Author(s)
笹野智之, 冨., 栗谷健太郎, 澤田育子, 高橋恵, 木瀬康人, 後安聡子, 味村和哉, 熊澤恵一, 木村敏啓, 谷口友基子, 橋本香映, 金川武司, 木村正
Organizer
第126回近畿産科婦人科学会学術集会
Place of Presentation
大阪
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[Presentation] 大阪大学病院における電子カルテによる遺伝子情報管理の取り組み2011
Author(s)
佐藤友紀, 酒井規夫, 金川武司, 大友孝信, 濱田悠介, 國府力, 小巻正泰, 吉津紀久子, 西田千夏子, 市村沙希, 上田郁奈代, 松村泰志, 野口眞三郎
Organizer
遺伝医学合同学術集会2011
Place of Presentation
京都大学(京都)
Related Report
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