Nuclear matrix associating factors, Satb, are novel regulators of murine placentation
| Project/Area Number |
23592405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Kotaro 九州大学病院, 産科婦人科, 講師 (40304779)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 胎盤 / 栄養膜幹細胞 / 分化 / 転写因子 / 転写調節 / 国際情報交換 / 胎盤栄養膜幹細胞 / 転写調節機構 |
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| Research Abstract |
We identified novel regulators of trophoblast cell differentiation, Satb1 and Satb2. They had been known as nuclear matrix associating molecules. Satb1 and Satb2 are necessary to maintain rodent trophoblast cells at stem cell condition. We also discovered Eomes as a target gene of Satb1 and Satb2. Eomes is a well-known regulator necessary for maintenance of trophoblast stem cells. Therefore, Satb1 and Satb2 upregulate Eomes expression to keep trophoblast cells from differentiation. We published these results as a paper (Asanoma et al., 2012).
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Inhibition of AHR transcription by NF1C is affected by a single nucleotide polymorphism, and is involved in suppression of human uterine endometrial cancer2013
Author(s)
Li D, Takao T, Tsunematsu R, Morokuma S, Fukushima K, Kobayashi H, Saito T, Furue M, Wake N, Asanoma K
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Journal Title
Oncogene
Volume: 32
Pages: 4950-4959
Related Report
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[Journal Article] Inhibition of AHR transcription by NF1C is affected by a single-nucleotide polymorphism, and is involved in suppression of human uterine endometrial cancer.2012
Author(s)
Li D, Takao T, Tsunematsu R, Morokuma S, Fukushima K, Kobayashi H, Saito T, Furue M, Wake N, Asanoma K
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Journal Title
Oncogene
Volume: in press
Issue: 41
Pages: 4950-4959
DOI
Related Report
Peer Reviewed
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