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Identification of cell-free placental mRNAs/microRNAs and their clinical significance

Research Project

Project/Area Number 23592406
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNagasaki University

Principal Investigator

MIURA KIYONORI  長崎大学, 医歯(薬)学総合研究科, 准教授 (00363490)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords胎盤機能 / RNA / 母体血 / 胎盤 / 胎児 / microRNA / 胎児発育不全 / 母体血漿 / C19MC / 遺伝子 / 核酸 / マイクロRNA
Research Abstract

1)Placenta-specific miRNA located on 19q13.42 in maternal plasma were identified. 2) Expression levels of placenta-specific miRNAs during 3rd trimester were twice or more than those during first trimester. 3)-1. In cases of monochorionic diamniotic twins, the measurement of cell-free placenta-specific miRNAs may be predictive markers for twin to twin transfusion syndrome (TTTS). 3)-2. Circulating levels of placenta-specific miRNAs was associated with the status of preeclampsia. 3)-3. Circulating levels of placenta-specific miRNAs was associated with fetal growth. 3)-4. The plasma CHM-miRNAs could be an additional follow-up marker for malignant changes of CHM. 4) The measurement of cell-free pregnancy-associated placenta-specific miRNAs levels in maternal plasma may reflect the pregnancy status related to placenta volume.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (86 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (47 results) (of which Peer Reviewed: 7 results) Presentation (33 results) (of which Invited: 2 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Placental mesenchymal dysplasia differentially diagnosed from molar pregnancy by 3-D inversion mode rendering : A case report2014

    • Author(s)
      Minekawa-Mehandjiev R, Masuda K, Yamamoto K, Miura K, Nakayama M, Murata Y
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Pages: 284-287

    • Related Report
      2013 Final Research Report
  • [Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome2014

    • Author(s)
      Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura KI, Masuzaki H
    • Journal Title

      Prenat Diagn

      Volume: 34 Pages: 345-349

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of Endometrioid Endometrial Carcinoma-associated microRNAs in Tissue and Plasma2014

    • Author(s)
      Tsukamoto O, Miura K, Mishima H, Abe S, Kaneuchi M, Higashijima A, Miura S, Kinoshita A, Yoshiura KI, Masuzaki H
    • Journal Title

      Gynecologic Oncology

      Volume: 132 Pages: 715-21

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Genome-wide Association Study of HPV Associated Cervical Cancer in Japanese Women2014

    • Author(s)
      Miura K, Mishima H, Kinoshita A, Hayashida C, Abe S, Tokunaga K, Masuzaki H, Yoshiura KI
    • Journal Title

      Journal of Medical Virology

      Volume: 86 Pages: 1153-8

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 母体血を用いた胎児診断2014

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      日本産婦人科・新生児血液学会誌

      Volume: 23巻2号 Pages: 9-18

    • Related Report
      2013 Final Research Report
  • [Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome2014

    • Author(s)
      Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura KI, Masuzaki H.
    • Journal Title

      Prenatal Diagnosis

      Volume: 34 Issue: 4 Pages: 345-349

    • DOI

      10.1002/pd.4307

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placental mesenchymal dysplasia differentially diagnosed from molar pregnancy by 3-D inversion mode rendering: A case report2014

    • Author(s)
      Minekawa-Mehandjiev R, Masuda K, Yamamoto K, Miura K, Nakayama M, Murata Y
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 1 Pages: 284-287

    • DOI

      10.1111/jog.12152

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uniparental disomy analysis in trios using genome-wide SNP array and whole-genome sequencing data imply segmental uniparental isodisomy in general populations2013

    • Author(s)
      Sasaki K, Mishima H, Miura K, Yoshiura KI
    • Journal Title

      Gene

      Volume: 512 Pages: 267-274

    • NAID

      120006985901

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Aggressive ovarian plasmacytoma resistant to radiation and chemotherapy2013

    • Author(s)
      Yamasaki K, Miura K, Abe K, Masuzaki H
    • Journal Title

      ACTA MEDICA NAGASAKIENSIA

      Volume: 58 Pages: 9-12

    • NAID

      130004451032

    • Related Report
      2013 Final Research Report
  • [Journal Article] A case of chorioangioma with polyhydramnios2013

    • Author(s)
      Yoshida A, Murakami Y, Masuzaki M, Miura K, Masuzaki H
    • Journal Title

      ACTA MEDICA NAGASAKIENSIA

      Volume: 58 Pages: 29-31

    • NAID

      110009577020

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of placenta-specific microRNAs in fetal growth restriction pregnancy2013

    • Author(s)
      Higashijima A, Miura K, Mishima H, Kinoshita A, Jo O, Abe S, Hasegawa Y, Miura S, Yamasaki K, Yoshida A, Yoshiura KI, and Masuzaki H
    • Journal Title

      Prenatal Diagnosis

      Volume: 33 Pages: 214-222

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer2013

    • Author(s)
      Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Sasaki K, Yoshida A, Yoshiura KI, and Masuzaki H
    • Journal Title

      J Hum Genet

      Volume: 58 Pages: 250-253

    • NAID

      10031177218

    • Related Report
      2013 Final Research Report
  • [Journal Article] A triploid partial mole placenta from paternal isodisomy with a diploid fetus derived from one sperm and one oocyte may have caused angiogenic imbalance leading to preeclampsia-like symptoms at 19 weeks of gestation2013

    • Author(s)
      Yoneda N, Shiozaki A, Miura K, Yonezawa R, Takemura K, Yoneda S, Masuzaki H, Saito S
    • Journal Title

      Placenta

      Volume: 34 Pages: 631-634

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
  • [Journal Article] IFPA Meeting 2012 Workshop Report III : Trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis2013

    • Author(s)
      Al-Khan A, Bulmer JN, Chantraine F, Chen CP, Chen Q, Collins S, Cotechini T, Fitzgerald JS, He M, Holland O, Hung TH, Illsley NP, Ino K, Iwaki T, Kanayama N, Kaneki E, Katabuchi H, Kobayashi Y, Kondo A, Masuzaki H, Matjila M, Miura K, Mori A, Murthi P, Nagahashi K, Nie G, Ohba T, Sood R, Sugimura M, Takizawa T, Usui H, Velicky P, Lash GE.
    • Journal Title

      Placenta

      Volume: S0143-4004 (12) Pages: 453-455

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of Complete Hydatidiform Mole Pregnancy-associated MicroRNAs in Plasma2013

    • Author(s)
      Hasegawa Y, Miura K, Furuya K, Yoshiura KI, Masuzaki H
    • Journal Title

      Clinical Chemistry

      Volume: 59 Pages: 1410-1412

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix2013

    • Author(s)
      Hamaguchi D, Miura K, Abe S, Kinoshita A, Miura S, Yamasaki K, Yoshiura K, Masuzaki H
    • Journal Title

      J Med Virol

      Volume: 85 Pages: 2093-2100

    • Related Report
      2013 Final Research Report
  • [Journal Article] HTLV-12013

    • Author(s)
      三浦清徳、築山尚史、増崎英明
    • Journal Title

      臨床婦人科産科

      Volume: 67巻1号 Pages: 152-162

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 胎児超音波検査を用いた出生前診断の現状と今後の方向性2013

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      日本遺伝カウンセリング学会誌

      Volume: 第34巻1号 Pages: 5-10

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 母体血による胎児DNA診断2013

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      産科と婦人科

      Volume: 80巻9号 Pages: 1206-1215

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 絨毛由来cell-free DNA/RNA2013

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      産婦人科の実際

      Volume: 62巻8号 Pages: 1047-1055

    • Related Report
      2013 Final Research Report
  • [Journal Article] 胎児徐脈性不整脈2013

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      ペリネイタルケア画像で見る産科学

      Volume: 32巻10号 Pages: 2-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] 胎児染色体異常の母体血による出生前診断2013

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      九州連合産科婦人科学会誌

      Volume: 64巻 Pages: 23-29

    • Related Report
      2013 Final Research Report
  • [Journal Article] Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix2013

    • Author(s)
      Hamaguchi D, Miura K, Abe S, Kinoshita A, Miura S, Yamasaki K, Yoshiura K, Masuzaki H
    • Journal Title

      Journal of Medical Virology

      Volume: 85 Issue: 12 Pages: 2093-2100

    • DOI

      10.1002/jmv.23709

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer.2013

    • Author(s)
      Abe, S, Miura, K, Kinoshita, A, Mishima, H, Miura, S, Yamasaki, K, Hasegawa, Y, Higashijima, A, Jo, O, Sasaki, K, Yoshida, A, Yoshiura, KI, Masuzaki.
    • Journal Title

      Journal of Human Genetics

      Volume: 58 Issue: 5 Pages: 250-253

    • DOI

      10.1038/jhg.2013.7

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aggressive Ovarian Plasmacytoma Resistant to Radiochemotherapy: Case Report2013

    • Author(s)
      Yamasaki K, Miura K, Abe K, Masuzaki H
    • Journal Title

      ACTA MEDICA NAGASAKIENSIA

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ultrasound Prediction of Amniotic Fluid Volume2012

    • Author(s)
      Masuzaki M, Yoshida A, Miura K, Masuzaki H
    • Journal Title

      ACTA MEDICA NAGASAKIENSIA

      Volume: 57 Pages: 41-44

    • NAID

      110009442898

    • Related Report
      2013 Final Research Report
  • [Journal Article] 生殖医療による妊娠にみられる遺伝的課題2012

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      日本遺伝カウンセリング学会誌

      Volume: 33(1) Pages: 37-39

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] HTLV-I2012

    • Author(s)
      築山尚史、三浦清徳、増崎英明
    • Journal Title

      臨床婦人科産科

      Volume: 66(5) Pages: 182-189

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 胎児・胎盤機能の分子評価法の確立とその臨床的意義に関する研究2012

    • Author(s)
      三浦清徳
    • Journal Title

      産科と婦人科

      Volume: 79(7) Pages: 907-909

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] hCGの種類と測定法の問題点2012

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      臨床婦人科産科

      Volume: 66(7) Pages: 654-662

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 胎児ストレスマーカーとしての臍帯血ナトリウム利尿ペプチドホルモンの有用性の検討2012

    • Author(s)
      大坪善数、阿部修平、野々下晃子、三浦清徳、布施正樹、村上誠
    • Journal Title

      周産期医学

      Volume: 42(7) Pages: 935-939

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 幸帽児分娩2012

    • Author(s)
      阿部修平、三浦清徳、増崎英明
    • Journal Title

      ペリネイタルケア

      Volume: 31(1) Pages: 10-13

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 脳腫瘍合併妊娠2012

    • Author(s)
      濱口大輔、宮崎恭子、三浦清徳、増崎英明
    • Journal Title

      ペリネイタルケア

      Volume: 31(10)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 出生前診断の対象疾患2012

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      臨床婦人科産科

      Volume: 66(12) Pages: 1054-1062

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Clinical application of fetal sex determination using cell-free fetal DNA in pregnant carriers of X-linked genetic disorders2011

    • Author(s)
      Miura K, Higashijima A, Shimada T, Miura S, Yamasaki K, Abe S, Jo O, Kinoshita A, Yoshida A, Yoshimura S, Niikawa N, Yoshiura K, and Masuzaki H
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Pages: 296-299

    • NAID

      40018765629

    • Related Report
      2013 Final Research Report
  • [Journal Article] Epidemiology of human papillomavirus genotypes in pregnant Japanese women2011

    • Author(s)
      Yamasaki K, Miura K, Shimada T, Miura S, Abe S, Murakami M, Sameshima T, Fujishita A, Kotera K, Kinoshita A, Yoshiura K, and Masuzaki H
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Pages: 313-315

    • NAID

      10030658951

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pre-vaccination epidemiology of human papillomavirus infections in Japanese women with abnormal cytology2011

    • Author(s)
      Yamasaki K, Miura K, Shimada T, Ikemoto R, Miura S, Murakami M, Sameshima T, Fujishita A, Kotera K, Kinoshita A, Yoshiura K, Masuzaki H
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 37 Pages: 1666-1670

    • NAID

      120006985461

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] 癒着胎盤の早期診断2011

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      母体血からの情報周産期医学

      Volume: 41巻4号 Pages: 487-49

    • Related Report
      2013 Final Research Report
  • [Journal Article] 胎児形態異常(胎児奇形)と遺伝カウンセリング2011

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      産婦人科の実際

      Volume: 60(9) Pages: 1293-1298

    • Related Report
      2013 Final Research Report
  • [Journal Article] 18トリソミー2011

    • Author(s)
      淵直樹、三浦清徳、増崎英明
    • Journal Title

      ペリネイタルケア

      Volume: 30(11) Pages: 956-959

    • Related Report
      2013 Final Research Report
  • [Journal Article] HTLV-12011

    • Author(s)
      三浦清徳、増崎英明
    • Journal Title

      臨床婦人科産科

      Volume: 65(8) Pages: 1029-1037

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical application of fetal sex determination using cell-free fetal DNA in pregnant carriers of X-linked genetic disorders.2011

    • Author(s)
      Miura K, Higashijima A, Shimada T, Miura S, Yamasaki K, Abe S, Jo O, Kinoshita A, Yoshida A, Yoshimura S, Niikawa N, Yoshiura K, and Masuzaki H
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Pages: 296-299

    • NAID

      40018765629

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of human papillomavirus genotypes in pregnant Japanese women.2011

    • Author(s)
      Yamasaki K, Miura K, Shimada T, Miura S, Abe S, Murakami M, Sameshima T, Fujishita A, Kotera K, Kinoshita A, Yoshiura K, and Masuzaki H
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Pages: 313-315

    • NAID

      10030658951

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Guidelines for obstetrical practice in Japan : Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition

    • Author(s)
      Minakami H, Maeda T, Fujii T, Hamada H, Iitsuka Y, Itakura A, Itoh H, Iwashita T, Kanagawa T, Kanai M, Kasuga Y, Kawabata M, Kobayashi K, Kotani T, Kudo Y, Makino Y, Matsubara S, Matsuda H, Miura K, Murakoshi T, Murotsuki J, Ohkuchi A, Ohno Y, Ohshiba Y, Satoh S, Sekizawa A, Sugiura M, Suzuki S, Takahashi T, Tsukahara Y, Unno N, Yoshikawa H
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US

    • Author(s)
      Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Yoshida A, Kaneuchi M, Yoshiura KI and Masuzaki H
    • Journal Title

      Journal of Human Genetics

      Volume: (in press)

    • NAID

      40020066482

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical Applications of Analysis of Plasma Circulating Complete Hydatidiform Mole Pregnancy-Associated miRNAs in Persistent Gestational Trophoblastic Disease

    • Author(s)
      Miura K, Hasegawa Y, Abe S, Higashijima A, Miura S, Mishima H, Kinoshita A, Kaneuchi M, Yoshiura KI, Masuzaki H
    • Journal Title

      Placenta

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Circulating levels of maternal plasma cell-free pregnancy-associated placenta-specific microRNAs are associated with placental weight

    • Author(s)
      Miura K, Morisaki S, Abe S, Higashijima A, Hasegawa Y, Miura S, Tateishi S, Mishima H, Yoshiura KI, Masuzaki H
    • Journal Title

      Placenta

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮頸部すりガラス細胞癌の一例2014

    • Author(s)
      三浦清徳、河野通晴、淵 直樹、東島 愛、平木宏一、増崎英明
    • Organizer
      第54回日本婦人科腫瘍学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京都港区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胎盤特異的mRNAに関連すると推定されるmicroRNAの網羅的解析2013

    • Author(s)
      三浦清徳、東島愛、長谷川ゆり、阿部修平、築山尚史、三浦生子、山崎健太郎、吉田敦、増崎英明
    • Organizer
      第65回日本産婦人科学会学術講演会
    • Place of Presentation
      ロイトン札幌、札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 胎児染色体異常の母体血による出生前診断2013

    • Author(s)
      三浦清徳、増崎英明
    • Organizer
      第70回九州連合産科婦人科学会
    • Place of Presentation
      熊本市国際交流会館・ホテル日航熊本,熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 長崎県における出生年代別にみた妊婦HTLV-1キャリアの比較検討2013

    • Author(s)
      三浦清徳、築山尚史、森内浩幸、増崎英明
    • Organizer
      第49回日本周産期新生児医学会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮頸部すりガラス細胞癌の一例2013

    • Author(s)
      三浦清徳、河野通晴、淵直樹、東島愛、平木宏一、増崎英明
    • Organizer
      第54回日本婦人科腫瘍学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA,東京
    • Related Report
      2013 Final Research Report
  • [Presentation] HTLV-1キャリア妊婦から出生した児における臍帯血中のHTLV-1抗体価およびプロウイルス量に関する検討2013

    • Author(s)
      三浦清徳、築山尚史、猪口直子、佐々木大介、上平憲、柳原克紀、森内浩幸、吉浦孝一郎、増崎英明
    • Organizer
      第6回HTLV-1研究会・シンポジウム
    • Place of Presentation
      東京大学医科学研究所講堂、東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 腹腔鏡下手術で摘出したfetiform teratomaの一例2013

    • Author(s)
      三浦清徳、阿部修平、河野道晴、中山大介、北島道夫、増崎英明
    • Organizer
      日本婦人科内視鏡学会
    • Place of Presentation
      ウインクあいち,名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer2013

    • Author(s)
      Kiyonori Miura, Shuhei Abe, Akira Kinoshita, Hiroyuki Mishima, Shoko Miura, Koh-ichiro Yoshiura, and Hideaki Masuzaki
    • Organizer
      63th Annual meeting of American Society of Human Genetics
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 急性虫垂炎と右卵管膨大部妊娠を併発していた急性腹症の1例2013

    • Author(s)
      三浦清徳、谷口憲、河野通晴、松本亜由美、増﨑英明
    • Organizer
      日本内視鏡外科学会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer2013

    • Author(s)
      Kiyonori Miura, Shuhei Abe, Akira Kinoshita, Hiroyuki Mishima, Shoko Miura, Koh-ichiro Yoshiura, and Hideaki Masuzaki
    • Organizer
      63th Annual meeting of American Society of Human Genetics
    • Place of Presentation
      Boston convention center(ボストン)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胎盤特異的mRNAに関連すると推定されるmicroRNAの網羅的解析2013

    • Author(s)
      三浦清徳、東島愛、長谷川ゆり、阿部修平、築山尚史、三浦生子、山崎健太郎、吉田敦、増崎英明
    • Organizer
      第65回日本産婦人科学会学術講演会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胎児染色体異常の母体血による出生前診断2013

    • Author(s)
      三浦清徳、増崎英明
    • Organizer
      第70回九州連合産科婦人科学会
    • Place of Presentation
      熊本市国際交流会館(熊本市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 長崎県における出生年代別にみた妊婦HTLV-1キャリアの比較検討2013

    • Author(s)
      三浦清徳、築山尚史、森内浩幸、増崎英明
    • Organizer
      第49回日本周産期新生児医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] HTLV-1キャリア妊婦から出生した児における臍帯血中のHTLV-1抗体価およびプロウイルス量に関する検討2013

    • Author(s)
      三浦清徳、築山尚史、猪口直子、佐々木大介、上平 憲、柳原克紀、森内浩幸、吉浦孝一郎、増崎英明
    • Organizer
      第6回HTLV-1研究会
    • Place of Presentation
      東京大学医科学研究所講堂(東京都港区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腹腔鏡下手術で摘出したfetiform teratomaの一例2013

    • Author(s)
      三浦清徳、阿部修平、河野道晴、中山大介、北島道夫、増崎英明
    • Organizer
      第53回日本婦人科内視鏡学会
    • Place of Presentation
      ウインクあいち(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急性虫垂炎と右卵管膨大部妊娠を併発していた急性腹症の1例2013

    • Author(s)
      三浦清徳、谷口 憲、河野通晴、松本亜由美、増﨑英明
    • Organizer
      第26回日本内視鏡外科学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of Pregnancy-Associated microRNAs in Maternal Plasma2012

    • Author(s)
      Kiyonori Miura, Ai Higashijima, Shoko Miura, Kentaro Yamasaki, Ozora Jo, Shuhei Abe , Yuri Hasegawa, Koh-ichiro Yoshiura and Hideaki Masuzaki
    • Organizer
      The 16th International Conference on Prenatal Diagnosis and Therapy
    • Place of Presentation
      Maiami, Florida, USA
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 胎児超音波検査を用いた出生前診断の現状と今後の方向性2012

    • Author(s)
      三浦清徳、増崎英明
    • Organizer
      第36回日本遺伝カウンセリング学会
    • Place of Presentation
      長野
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 母体血を用いた胎児診断2012

    • Author(s)
      三浦清徳、増崎英明
    • Organizer
      第22回日本産婦人科・新生児血液学会
    • Place of Presentation
      三重
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 母体血中のDNA/RNAを用いた診断・検査の産科診療への応用2012

    • Author(s)
      三浦清徳、増崎英明
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 母体血中DNAを用いた胎児診断2012

    • Author(s)
      三浦清徳、増崎英明
    • Organizer
      第57回日本生殖医学会
    • Place of Presentation
      長崎
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Identification of pregnancy-associated microRNAs and their circulating levels in plasma from normal pregnant women and pre-eclamptic women2012

    • Author(s)
      Kiyonori Miura, Hideaki Masuzaki
    • Organizer
      Internatinal Federation of Placenta Associations Meetings 2012
    • Place of Presentation
      Hiroshima, Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] cell-free fetal DNA/RNAの臨床応用2011

    • Author(s)
      三浦清徳
    • Organizer
      ブロック別出生前診断研究会
    • Place of Presentation
      京都大学百周年時計台記念館,京都
    • Year and Date
      2011-06-17
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム:生殖医療による妊娠にみられる遺伝的課題2011

    • Author(s)
      三浦清徳、増崎英明
    • Organizer
      遺伝医学合同学術集会2011
    • Place of Presentation
      京都大学百周年時計台記念館、京都
    • Year and Date
      2011-06-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 全胞状奇胎特異的microRNAの同定とその臨床応用に関する検討2011

    • Author(s)
      三浦清徳、山崎健太郎、平木宏一、増崎英明
    • Organizer
      第50回日本婦人科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 全胞状奇胎特異的microRNAの網羅的解析2011

    • Author(s)
      三浦清徳、長谷川ゆり、東島愛、城大空、阿部修平、三浦生子、山崎健太郎、吉田敦、吉村秀一郎、吉浦孝一郎、増﨑英明
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 成熟卵から発生していたfetiform teratomaの一例2011

    • Author(s)
      三浦清徳、倉林工、佐々木健作、石黒竜也、阿部修平、吉浦孝一郎、増崎英明
    • Organizer
      第56回日本生殖医学会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] cell-free fetal DNA/RNAの臨床応用2011

    • Author(s)
      三浦清徳
    • Organizer
      ブロック別出生前診断研究会(招待講演)
    • Place of Presentation
      京都大学百周年時計台記念館(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 子宮内胎児発育遅延と関連する胎盤特異的microRNAの検出2011

    • Author(s)
      東島 愛、三浦清徳、城 大空、長谷川ゆり、山崎健太郎、三浦生子、吉村秀一郎、増崎英明
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] 全胞状奇胎特異的 microRNA の同定とその臨床応用に関する検討2011

    • Author(s)
      三浦清徳、山崎健太郎、平木宏一、増崎英明
    • Organizer
      第50回日本婦人科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] 全胞状奇胎特異的microRNAの網羅的解析2011

    • Author(s)
      三浦清徳、長谷川ゆり、東島 愛、城 大空、阿部修平、三浦生子、山崎健太郎、吉田 敦、吉村秀一郎、吉浦孝一郎、増崎英明
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2011 Research-status Report
  • [Presentation] Identification of pregnancy-associated microRNAs and their circulating levels in plasma from normal pregnant women and pre-eclamptic women2010

    • Author(s)
      Kiyonori Miura and Hideaki Masuzaki
    • Organizer
      Internatinal Federation of Placenta Associations Meetings 2012
    • Place of Presentation
      Hiroshima, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation]

    • Author(s)
      三浦清徳、倉林工、石黒竜也、阿部修平、東島愛、城大空、平木宏一、吉田敦、吉村秀一郎、吉浦孝一郎、増崎英明
    • Organizer
      第64回日本産科婦人科学会・学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Book] 肥満患者の術野の確保法日本産婦人科・新生児血液学会誌OGS Now No.17知っておくと役立つ腔の展開法、鉤の使い方と術後機能温存法2014

    • Author(s)
      三浦清徳、増崎英明
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/gyneclgy/

    • Related Report
      2013 Final Research Report
  • [Remarks] 長崎大学産婦人科ホームページ

    • URL

      http://www.med.nagasaki-u.ac.jp/gyneclgy/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 長崎大学医学部産婦人科

    • URL

      http://www.med.nagasaki-u.ac.jp/gyneclgy/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/gyneclgy/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 胎盤機能の網羅的かつ非侵襲的評価方法および検査用試薬2014

    • Inventor(s)
      三浦清徳、増﨑英明、新川詔夫、吉 浦孝一郎、山崎健太郎、三浦生子
    • Industrial Property Rights Holder
      国立大学法人 長崎大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-03-07
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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