| Project/Area Number |
23592408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUZUKI Yoshikatsu 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (30254288)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tamao 名古屋市立大学, 大学院医学研究科, 研究員 (20405210)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Takeo 名古屋市立大学, 大学院医学研究科, 教授 (70159888)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 妊娠高血圧症候群 / 血管内皮機能障害 / 診察室外血圧 / 降圧治療 / L-アルギニン / 葉酸 / 妊婦 / 高血圧 / 血管内皮機能 / 発症予知 / 発症予防 |
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| Research Abstract |
The aim is to improve the endothelial cells dysfunction seen in pregnancy induced hypertension (PIH). The diagnosis of hypertension of PIH was established by home blood pressure measurement and 24 hour ambulatory blood pressure monitoring instead of clinic BP. Furthermore, endothelial cell function was evaluated by flow mediated vasodilatation (FMD) of brachial artery by hyperemia. Administration of L-arginine plus folic acids might improve reduced FMD in high risk women of PIH and prevent from PIH, especially preeclampsia. While oral administration of labetalol could stabilized BP in PIH, especially gestational hypertension, nicardipine iv. could inhibit severe hypertension in puerperal women complicated by hypertensive emergency.
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