investigation of molecular targeted therapy in gynecologic malignancies
Project/Area Number |
23592409
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Nara Medical University |
Principal Investigator |
FURUKAWA naoto 奈良県立医科大学, 医学部, 講師 (50347556)
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Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hiroshi 奈良県立医科大学, 医学部, 教授 (40178330)
YOSHIDA Shozo 奈良県立医科大学, 医学部, 助教 (40347555)
NARUSE Katsuhiko 奈良県立医科大学, 医学部, 助教 (70453165)
SHIGETOMI Hiroshi 奈良県立医科大学, 医学部, 助教 (20433336)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 卵巣癌 / 転写因子 / 細胞周期 / 酸化ストレス |
Research Abstract |
We investigated the molecular targeted therapy in a viewpoint of Hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell carcinoma of ovary. We found that G2 cell-cycle arrest is induced through adenoviral transfer of HNF-1beta. CHK1 kinase acts downstream of ATM/ATR kinase and plays an important role in the G2 checkpoint. G2 arrest of HNF-1beta (+) cells results from sustained CHK1 activation.Furthermore, HNF-1beta controls claspin expression, sustaining CHK1 protein phosphorylation. These data indicated that the anticancer drug resistance of CCA may be caused by aberrant G2 arrest due to HNF-1A overexpression.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Evaluation of the BRCA1/2 mutation as a prognostic marker in primary peritoneal serous cancer2013
Author(s)
Naoto Furukawa, Sumire Ohno, Takahiko Kasai, Sachiko Morioka, Fuminori Ito, Yasuhito Tanase, Shoji Haruta, Seiji Kanayama, Ryuji Kawaguchi, Shozo Yoshida, Hiroshi Kobayashi
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Journal Title
open j obstet gynecol
Volume: 3
Issue: 09
Pages: 39151-39151
DOI
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Peer Reviewed
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[Journal Article] Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)2012
Author(s)
Tanase Y, Yamada Y, Shigetomi H, Kajihara H, Oonogi A, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H
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Journal Title
Exp Ther Med
Volume: 3(1)
Pages: 18-24
Related Report
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[Journal Article] Modulation of estrogenic action in clear cell carcinoma of the ovary (Review).2012
Author(s)
Tanase Y, Yamada Y, Shigetomi H, Kajihara H, Oonogi A, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H.
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Journal Title
Exp Ther Med.
Volume: 3
Issue: 1
Pages: 18-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary2011
Author(s)
Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H
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Journal Title
Int J Gynecol Cancer
Volume: 21(7)
Pages: 1200-7
Related Report
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[Journal Article] Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary.2011
Author(s)
Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H.
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Journal Title
Int J Gynecol Cancer.
Volume: 21
Pages: 1200-7
DOI
Related Report
Peer Reviewed
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[Presentation] 明細胞腺癌における転写因子HNF-1betaが制御するDNA損傷チェックポイント機構の解明2013
Author(s)
重富洋志,植栗千陽,梶原宏貴,棚瀬康仁,春田祥治,金山清二,川口龍二,吉田昭三,古川直人,大井豪一,小林浩,島田啓司,須藤保
Organizer
2013日本婦人科がん分子標的研究会学術集会
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[Presentation] Evaluation of BRCA1 Gene Expression as a Prognostic Marker Peritoneal Cancer2012
Author(s)
Furukawa N, Nagai A, Kasai T, Ohno S,Shigemitsu Y, Tanase Y, Haruta S, Kawaguchi R,Yoshida S, Oi H, Kobayashi H
Organizer
2012 Biennial Meeting of the International Gynecologic Cancer Society
Related Report
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[Presentation] 明細胞腺癌におけるDNA損傷応答と転写因子HNF-1beta2012
Author(s)
重富洋志,須藤保,吉澤順子,棚瀬康仁,春田祥治,金山清二,永井景,川口龍二,吉田昭三,古川直人,大井豪一,小林浩
Organizer
2012日本エンドメトリオーシス学会
Related Report
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[Presentation] 卵巣明細胞腺癌における転写因子HNF-1betaのDNA損傷チェックポイント機構の制御2012
Author(s)
重富洋志,須藤保,吉澤順子,棚瀬康仁,春田祥治,金山清二,永井景,川口龍二,吉田昭三,古川直人,大井豪一,小林浩
Organizer
2012日産婦
Related Report
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[Presentation] Evaluation of BRCA1 Gene Expression as a Prognostic Marker Peritoneal Cancer.2012
Author(s)
Furukawa N, Nagai A, Kasai T, Ohno S, Shigemitsu Y, Tanase Y, Haruta S, Kawaguchi R, Yoshida S, Oi H, Kobayashi H.
Organizer
14th Biennial Meeting of the International Gynecologic Cancer Society
Place of Presentation
Canada
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