| Project/Area Number |
23592412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITAKURA Atsuo 順天堂大学, 医学部, 教授 (70262897)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Osamu 埼玉医科大学, 医学部, 教授 (70176212)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生殖医学 / 着床 / 不妊症 / 子宮内膜 / 脱落膜化 / ヘパリン / 酸化ストレス / 子宮内膜脱落膜化 / microRNA / 転写因子 |
|---|
| Research Abstract |
A recent clinical trial demonstrated a beneficial effect of heparin administration in the luteal phase on implantation rate as well as the live birth rate in women with repeated implantation failure. However, the precise effects of heparin on decidualization process remain uncertain. Addition of heparin at various concentrations to decidualized HESCs caused a dose-dependent increase of PRL secretion. Decidualized HESCs treated with heparin dose-dependently prevented the cell death rate induced by oxidative stress. Heparin augmented both FOXO1 and SOD2 protein expression. These results demonstrate that heparin-treated decidualized HESCs acquired resistance to oxidative stress by induced expression of FOXO1 and SOD2, suggesting that heparin may improve the uterine environment for successful implantation.
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