Prediction and prevention of preeclampsia
Project/Area Number |
23592417
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Showa University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YOTSUMOTO Jyunko 昭和大学, 医学部, 特別研究生 (30553648)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 妊娠高血圧症候群 / 胎盤 / 妊娠初期絨毛 / 妊娠高血圧腎症 / 血管増殖因子 / 母体血漿RNA / 胎盤形成期 / 抗血管増殖因子 / FLT-1 / 初期絨毛 / 母体血RNA / 抗酸化剤 / エンドグリン |
Research Abstract |
We investigated the influence of maternal smoking on the early placental expression of genes related to angiogenesis and oxidative stress. As a result, we revealed that VEGFA placental expression was higher in smoking women at 10-11 weeks of gestation. Increased VEGFA expression in the early stages of pregnancy in smoking women might contribute to the decreased risk of developing preeclampsia. Next, we investigated the benefit of antioxidant supplementation in a cohort of women with low antioxidant status.Pregnant women who had low antioxidant status treated with either antioxidants or control diets daily from 8-12 weeks. 110 women were enrolled, randomly assigned to the supplementation (n = 52) and control group (n = 58). There were significant differences (P=0.034) between the supplementation and control group in the incidence of pre-eclampsia (2.0% and 14.5%, respectively). We revealed supplementation of antioxidants during early gestation might reduce the risk of pre-eclampsia.
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Report
(4 results)
Research Products
(30 results)