Grant-in-Aid for Scientific Research (C)
This study was conducted in order to elucidate the molecular mechanism of proteinurea onset accompanied with pregnancy-induced hypertension (PIH). Primary podocytes (glomerular epithelial cells) were treated with endothelin-1 to induce cellular injury to the cells, whereby an in vitro pathological model reflecting the PIH-related proteinurea was established. Further, transcripts (including non-coding RNAs) dysregulated in accordance with the podocyte injury were explored in a genome-wide fashion by means of next-generation sequencing and PCR-based microRNA array system.
Nucleic Acids Res
J. Bone Metab
Journal of Bone Metabolism
Attribution of KAKENHI