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The usefulness of G-CSF in the treatment of luteinized unruptured follicle (LUF) induced by clomiphene citrate (CC) / human menopausal gonadotrophin (hMG) and human chorionic gonadotrophin (hCG)

Research Project

Project/Area Number 23592422
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKanazawa Medical University

Principal Investigator

MAKINODA Satoru  金沢医科大学, 医学部, 教授 (80165688)

Co-Investigator(Kenkyū-buntansha) FUJII Ryota  金沢医科大学, 看護学部, 准教授 (30298351)
WASEDA Tomoo  金沢医科大学, 医学部, 講師 (40367488)
TOMIZAWA Hideki  金沢医科大学, 医学部, 助教 (40319059)
FUJITA Satoko  金沢医科大学, 医学部, 助教 (90350785)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords排卵障害 / G-CSF / サイトカイン
Research Abstract

For infertile patients with luteinized unruptured follicle (LUF) who did not ovulate in spite of the ovulation induction used by clomiphene citrate or gonadotropin and hCG, we administered granulocyte colony-stimulating factor (G-CSF) with the action to increase granulocytes which are one of blood components.
The ovulation rate of cycles when we did not give G-CSF was 50.0%. Compared with it, the ovulation rate increased to 90.3% with G-CSF. The increase is significant (P<0.001). In recent years, an in-vitro fertilization or intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) were not specific regimen by the progress of assisted reproductive technology (ART). However, these treatments are still expensive. In contrast, our method using G-CSF is cheaper and less invasive than ART. This method must be used at first for the patients suffering from LUF.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2013 2012 2011

All Presentation (19 results)

  • [Presentation] 黄体化未破裂卵胞(LUF)に対するG-CSFの治療効果2013

    • Author(s)
      藤井亮太
    • Organizer
      第18回日本生殖内分泌学会
    • Place of Presentation
      東京
    • Year and Date
      2013-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 黄体化未破裂卵胞(LUF)に対するG-CSFの治療効果について2013

    • Author(s)
      柴田健雄
    • Organizer
      第31回日本受精着床学会
    • Place of Presentation
      別府
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット排卵過程におけるgelatinaseの作用について2013

    • Author(s)
      藤井亮太
    • Organizer
      第65回日本産科婦人科学
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] The effectiveness of G-CSF in the treatment of LUF2013

    • Author(s)
      藤井亮太
    • Organizer
      The International Ovarian Conference 2013
    • Place of Presentation
      Taipei
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット排卵過程におけるgelatinaseの作用について2013

    • Author(s)
      藤井亮太、牧野田 知
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 黄体化未破裂卵胞(LUF)に対するG-CSFの治療効果について2013

    • Author(s)
      柴田健雄、藤井亮太、牧野田 知
    • Organizer
      第31回日本受精着床学会
    • Place of Presentation
      別府国際コンベンションセンター(大分県別府市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 黄体化未破裂卵胞(LUF)に対するG-CSFの治療効果2013

    • Author(s)
      藤井亮太、牧野田 知
    • Organizer
      第18回日本生殖内分泌学会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 黄体化未破裂卵胞(LUF)に対するG-CSFの治療効果について2012

    • Author(s)
      柴田健雄
    • Organizer
      第57回日本生殖医学会
    • Place of Presentation
      長崎
    • Related Report
      2013 Final Research Report
  • [Presentation] Granulocyte colony-stimulating factor (G-CSF) prevents LUF in clomiphene treatment2012

    • Author(s)
      藤井亮太
    • Organizer
      The 28^<th> of Annual Meeting of the ESHRE
    • Place of Presentation
      Turkey、Istanbul
    • Related Report
      2013 Final Research Report
  • [Presentation] 黄体化未破裂卵胞(LUF)に対するG-CSFの効果について2012

    • Author(s)
      藤井亮太
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 黄体化未破裂卵胞(LUF)に対するG-CSFの効果について2012

    • Author(s)
      藤井亮太
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸(神戸ポートピアホテル)
    • Related Report
      2012 Research-status Report
  • [Presentation] Granulocyte colony-stimulating factor (G-CSF) prevents LUF in clomiphene treatment2012

    • Author(s)
      藤井亮太
    • Organizer
      第28回欧州ヒト生殖学会
    • Place of Presentation
      Turkey(Istanbul)
    • Related Report
      2012 Research-status Report
  • [Presentation] 黄体化未破裂卵胞 (LUF) に対するG-CSFの治療効果について2012

    • Author(s)
      柴田健雄
    • Organizer
      第57回日本生殖医学会
    • Place of Presentation
      長崎(長崎ブリックホール)
    • Related Report
      2012 Research-status Report
  • [Presentation] 黄体化未破裂卵胞(LUF)の治療法-Granulocyte Colony-stimulation Factor (G-CSF)の効果2011

    • Author(s)
      富澤英樹
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel treatment of luteinized unruptured follicle caused by ovulation induction using clomiphene?human chorionic gonadotropin2011

    • Author(s)
      富澤英樹
    • Organizer
      The 27^<th> of Annual Meeting of the ESHRE
    • Place of Presentation
      Sweden、Stockholm
    • Related Report
      2013 Final Research Report
  • [Presentation] The involvement of granulocyte colony-stimulating factor (G-CSF) in the release of a mature oocyte2011

    • Author(s)
      藤井亮太
    • Organizer
      The 27th of Annual Meeting of the ESHRE
    • Place of Presentation
      Sweden、Stockholm
    • Related Report
      2013 Final Research Report
  • [Presentation] The involvement of granulocyte colony-stimulating2011

    • Author(s)
      藤井亮太
    • Organizer
      The 27th of Annual Meeting of the ESHRE
    • Place of Presentation
      Sweden(Stockholm)
    • Related Report
      2011 Research-status Report
  • [Presentation] A novel treatment of luteinized unruptured2011

    • Author(s)
      富澤英樹
    • Organizer
      The 27th of Annual Meeting of the ESHRE
    • Place of Presentation
      Sweden(Stockholm)
    • Related Report
      2011 Research-status Report
  • [Presentation] 黄体化未破裂卵胞(LUF)の治療法-Granulocyte Colony-stimulation2011

    • Author(s)
      富澤英樹
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      大阪(リーガロイヤルホテル大阪)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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