| Project/Area Number |
23592423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SHOJI Hiroki 金沢医科大学, 一般教育機構, 准教授 (10263873)
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| Co-Investigator(Kenkyū-buntansha) |
ARIKAWA Tomohiro 金沢医科大学, 一般教育機構, 講師 (70452670)
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| Co-Investigator(Renkei-kenkyūsha) |
SIMAMURA Eriko 金沢医科大学, 医学部, 講師 (00267741)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ガレクチン / 胎盤 / 妊娠 / 栄養膜細胞 / invasive trophoblast / 浸潤 / trophoblast / 合胞体 |
|---|
| Research Abstract |
Galectins comprise a family of animal lectin that bind to beta-galactoside-containing carbohydrates. In this study, we aimed to clarify the roles of galectins during placentation. Analysis of functions of galectins during the differentiation process of rat trophoblast cell line (Rcho-1 cell) revealed that down regulation of Galectin 4 expression may be involved in the promotion of trophoblast cell differentiation. The findings of current study contribute to the understanding of the regulatory mechanisms of placentation by members of galectin family.
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