Uterine leiomyoma and AMPK/mTOR signal transduction pathway- a new therapeutic strategy.

• Project/Area Number: 23592430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kinki University (2012-2013); Tohoku University (2011)
• Principal Investigator: TAKEDA Takashi 近畿大学, 東洋医学研究所, 教授 (20301260)
• Co-Investigator(Kenkyū-buntansha): TSUIJI Kenji 東北大学, 大学院医学系研究科, 助教 (40528155) ; LI Bin 東北大学, 大学院医学系研究科, 研究支援者 (20566814)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 子宮筋腫 / mTOR / メトホルミン / 細胞増殖 / 血管新生 / VEGF / 分子標的 / HIF1 / シグナル伝達 / ｍTOR / AMPK

Research Abstract

Metformin is an anti-diabetic drug that is used all over the world. We have proved its anti-tumor effect and anti-angiogenic effect through suppression of the mammalian target of rapamycin (mTOR) pathway.

Research Products

• [Journal Article] Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression (2013)
  • Author(s): Wong TF, Takeda T, Li B, Tsuiji K, Kondo A, Tadakawa M, Nagase S, Yaegashi N
  • Journal Title: Int J Clin Oncol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Curcumin induces cross-regulation between autophagy and apoptosis in uterine leiomyosarcoma cells (2013)
  • Author(s): Li B, Takeda T, Tsuiji K, Wong TF, Tadakawa M, Kondo A, Nagase S, Yaegashi N
  • Journal Title: Int J Gynecol Cancer Volume: 23(5) Pages: 803-8
  • Peer Reviewed
• [Journal Article] The antidiabetic drug metformin inhibits uterine leiomyoma cell proliferation via an AMP-activated protein kinase signaling pathway (2013)
  • Author(s): Li B, Takeda T, Tsuiji K, Kondo A, Kitamura M, Wong TF, Yaegashi N. Gynecol Endocrinol
  • Volume: 29(1)
  • Pages: 87-90
  • Peer Reviewed
• [Journal Article] Epigallocatechin-3-gallate potentiates curcumin's ability to suppress uterine leiomyosarcoma cell growth and induce apoptosis (2013)
  • Author(s): Kondo A, Takeda T, Li B, Tsuiji K, Kitamura M, Wong TF, Yaegashi N
  • Journal Title: Int J Clin Oncol Volume: 18(3) Pages: 380-8
  • Peer Reviewed
• [Journal Article] The antidiabetic drug metformin inhibits uterine leiomyoma cell proliferation via an AMP-activated protein kinase signaling pathway. (2013)
  • Author(s): Li B, Takeda T, Tsuiji K, Kondo A, Kitamura M, Wong TF, Yaegashi N.
  • Journal Title: Gynecol Endocrinol. Volume: 29 Issue: 1 Pages: 87-90
  • DOI: 10.3109/09513590.2012.706668
  • Peer Reviewed
• [Journal Article] Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition (2011)
  • Author(s): Wong TF, Takeda T, Li B, Tsuiji K, Kitamura M, Kondo A, Yaegashi N
  • Journal Title: Gynecol Oncol Volume: 122(1) Pages: 141-8
  • Peer Reviewed
• [Journal Article] Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition. (2011)
  • Author(s): Wong TF, Takeda T, Li B, Tsuiji K, Kitamura M, Kondo A, Yaegashi N.
  • Journal Title: Gynecol Oncol. Volume: 122 Pages: 141-148
  • Peer Reviewed
• [Presentation] The antidiabetic drug metformin inhibits angiogenesis in uterine leiomyoma in vitro (2014)
  • Author(s): Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N
  • Organizer: 日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18
• [Presentation] The anti-diabetic drug metformin suppresses VEGF secretion through inhibition of the mTOR / HIF-1αpathway in uterine leiomyoma cells (2014)
  • Author(s): Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N
  • Organizer: ISGE 2014
  • Place of Presentation: Firenze, Italy
  • Year and Date: 2014-03-08
• [Presentation] メタボリックシンドロームからみた、子宮筋腫に対する新治療法開発 (2012)
  • Author(s): 武田卓
  • Organizer: 第3回婦人科ホルモン依存性疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-26
• [Presentation] ウコン中のクルクミンによる子宮平滑筋肉腫細胞増殖抑制効果～mTORに対する分子標的療法の可能性 (2011)
  • Author(s): 黄志芳,武田卓,李賓,築地謙治,北村真理,近藤亜希子,八重樫伸生
  • Organizer: 第50回日本婦人科腫瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-22
• [Presentation] メトホルミンによる子宮筋腫細胞増殖抑制効果解析 (2011)
  • Author(s): 北村真理,李賓,築地謙治,黄志芳,近藤亜希子,武田卓,八重樫伸生
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-04-22
• [Presentation] メトホルミンによる子宮筋腫細胞増殖抑制効果～子宮筋腫モデル細胞株・ヒト子宮筋腫モデルマウスを用いた検討 (2011)
  • Author(s): 李 賓、武田 卓、築地 謙治、黄 志芳、北村真理、近藤 亜希子、八重樫 伸生
  • Organizer: 第63回日本産婦人科学会
  • Place of Presentation: 大阪
• [Presentation] The anti-diabetic drug metformin suppresses VEGF secretion through inhibition of the mTOR / HIF-1a pathway in uterine leiomyoma cells
  • Author(s): Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N
  • Organizer: ISGE
  • Place of Presentation: Firenze, Italy
• [Presentation] The anti-diabetic drug metformin inhibits angiogenesis through HIF-1/VEGF pathway in uterine leiomyoma in vitro
  • Author(s): Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N
  • Organizer: 日本産科婦人科学会
  • Place of Presentation: 東京
• [Remarks] 近畿大学東洋医学研究所
  • URL: http://www.med.kindai.ac.jp/toyo/
• [Remarks] 東北大学医学部産婦人科
  • URL: http://www.ob-gy.med.tohoku.ac.jp/laboratory/t-takeda.html
• [Remarks] 近畿大学東洋医学研究所
  • URL: http://www.med.kindai.ac.jp/toyo/
• [Remarks] 近畿大学東洋医学研究所ホームページ
  • URL: http://www.med.kindai.ac.jp/toyo/