Development of molecular targeted therapeutics and its biomarkers in endometrial and ovarian clear cell carcinomas

• Project/Area Number: 23592437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: ODA Katsutoshi 東京大学, 医学部附属病院, 准教授 (30359608)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 子宮体癌 / 卵巣癌 / 分子標的治療 / ゲノム解析 / バイオマーカー / PI3K / cyclin D1 / DNA修復 / PI３K / TP53 / アポトーシス / 遺伝子変異 / 卵巣明細胞腺癌 / Ras / 染色体コピー数異常 / マイクロサテライト不安定性 / 転移 / 診断的バイオマーカー / PI3K経路 / mTOR / PIK3CA / PTEN

Research Abstract

We elucidated a novel molecular targeted therapeutics and its predictive biomarkers in endometrial and ovarian clear cell adenocarcinomas, on basis of the aberrant signaling pathways in these cancers.
1. We found that a PI3K pathway inhibitor (dual PI3K/mTOR inhibitor) is effective in endometrial and ovarian clear cell adenocarcinomas. Furthermore, mutational status of KRAS and TP53 was indicated as predictive biomarkers to the PI3K/mTOR inhibitor.
2. We revealed that genome-wide analyses, including single nucleotide polymorphism arrays, are useful for both diagnosis and prediction of prognosis in synchronous endometrial and ovarian carcinomas. In addition, we reported that activation of cyclin D1 and disruption of DNA repair pathways play important roles in endometrial cancer.

Research Products

• [Journal Article] Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells (2014)
  • Author(s): A. Miyasaka, K. Oda, Y. Ikeda, O. Wada-Hiraike, T. Kashiyama, A. Enomoto, N. Hosoya, T. Koso, T. Fukuda, K. Inaaba, K. Sone, Y. Uehara, R. Kurikawa, K. Nagasaka, Y.Matsumoto, T. Arimoto, S. Nakagawa, H. Kuramoto, K. Miyagawa, T. Yano, K. Kawana, Y. Osuga, T. Fujii.
  • Journal Title: BMC Cancer Volume: 14 Issue: 1 Pages: 179-179
  • DOI: 10.1186/1471-2407-14-179
  • Peer Reviewed
• [Journal Article] Antitumor Activity and Induction of TP53-Dependent Apoptosis toward Ovarian Clear Cell Adenocarcinoma by the Dual PI3K/mTOR Inhibitor DS-7423. (2014)
  • Author(s): Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Nakagawa S, Matsuda K, McCormick F, Aburatani H, Yano T, Osuga Y, Fujii T
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e87220-e87220
  • DOI: 10.1371/journal.pone.0087220
  • Peer Reviewed
• [Journal Article] High-risk human papillomavirus correlates with recurrence after laser ablation for treatment of patients with cervical intraepithelial neoplasia 3: A long-term follow-up retrospective study (2014)
  • Author(s): Inaba K, Nagasaka K, Kawana K, Arimoto T, Matsumoto Y, Tsuruga T, Mori-Uchino M, Miura S, Sone K, Oda K, Nakagawa S, Yano T, Kozuma S, Fujii T
  • Journal Title: J Obstet Gynaecol Res Volume: 40 Issue: 2 Pages: 554
  • DOI: 10.1111/jog.12196
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo (2014)
  • Author(s): Taguchi A, Kawana K, Tomio K, Yamashita A, Isobe Y, Nagasaka K, Koga K, Inoue T, Nishida H, kojima S, Adachi K, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, kang JX, Arai H, Arita M, Osuga Y, Fujii T.
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e89605-e89605
  • DOI: 10.1371/journal.pone.0089605
  • Peer Reviewed
• [Journal Article] 婦人科系がんにおけるゲノム解読（TCGAの成果も含む） (2014)
  • Author(s): 織田克利
  • Journal Title: 実験医学増刊 Volume: in press
• [Journal Article] Low-grade endometrial stromal sarcoma developing in a postmenopausal woman under toremifene treatment for breast cancer. (2013)
  • Author(s): Kashiyama T, Oda K, Kawana K, Arimoto T, Kanetaka Y, Takazawa Y, Maeda D, Nakagawa S, Yano T, Kozuma S
  • Journal Title: J Obstet Gynaecol Res Volume: 39 Issue: 1 Pages: 424-429
  • DOI: 10.1111/j.1447-0756.2012.01915.x
  • Peer Reviewed
• [Journal Article] Retreatment with nedaplatin in patients with recurrent gynecological cancer after the development of hypersensitivity reaction to carboplatin (2013)
  • Author(s): Arimoto T, Oda K, Nakagawa S, Kawana K, Tsukazaki T, Adachi K, Matsumoto Y, Yano T, Kozuma S, Taketani Y
  • Journal Title: J Obstet Gynaecol Res Volume: 39 Issue: 1 Pages: 336
  • DOI: 10.1111/j.1447-0756.2012.01917.x
  • URL: https://pure.teikyo.jp/en/publications/62eeb92a-99af-4908-948a-e7a59ef8ddde
  • Peer Reviewed
• [Journal Article] Primary vaginal calculus in a middle-aged woman with mental and physical disabilities. (2013)
  • Author(s): Ikeda Y, Oda K, Matsuzawa N, Shimizu K
  • Journal Title: Int Urogynecol J Volume: 24 Issue: 7 Pages: 1229-1231
  • DOI: 10.1007/s00192-012-1902-0
  • Peer Reviewed
• [Journal Article] Effective treatment of pelvic lymphocele by lymphaticovenular anastomosis (2013)
  • Author(s): Todokoro T, Furniss D, Oda K, Kawana K, Narushima M, Mihara M, Kikuchi K, Hara H, Yano T, Koshima I
  • Journal Title: Gynecol Oncol Volume: E-pub Issue: 2 Pages: 209-214
  • DOI: 10.1016/j.ygyno.2012.11.014
  • Peer Reviewed
• [Journal Article] Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines (2013)
  • Author(s): Miyamoto Y, Nakagawa S, Wada-Hiraike O, Seiki T, Tanikawa M, Hiraike H, Sone K, Nagasaka K, Oda K, Kawana K, Nakagawa K, Fujii T, Yano T, Kozuma S, Taketani Y.
  • Journal Title: Oncol Rep. Volume: 29 Issue: 1 Pages: 51
  • DOI: 10.3892/or.2012.2072
  • Peer Reviewed
• [Journal Article] Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer (2013)
  • Author(s): Ikeda Y, Oda K, Hiraike-Wada O, Koso T, Miyasaka A, Kashiyama T, Tanikawa M, Sone K, Nagasaka K, Maeda D, Kawana K, Nakagawa S, Fukayama M, Tetsu O, Fujii T, Yano T, Kozuma S
  • Journal Title: Oncol Rep Volume: 30 Issue: 2 Pages: 584
  • DOI: 10.3892/or.2013.2515
  • NAID: 120007089077
  • Peer Reviewed
• [Journal Article] Genome wide association study of age at menarche in the Japanese population (2013)
  • Author(s): Tanikawa C, Okada Y, Takahashi A, Oda K, et al
  • Journal Title: PLoS One Volume: 8 Issue: 5 Pages: e63821-e63821
  • DOI: 10.1371/journal.pone.0063821
  • Peer Reviewed
• [Journal Article] Omega-3 Polyunsaturated Fatty Acids Suppress the Cystic Lesion Formation of Peritoneal Endometriosis in Transgenic Mouse Models (2013)
  • Author(s): Tomio K, Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.
  • Journal Title: PLoS One Volume: 8 Issue: 9 Pages: 2013-2013
  • DOI: 10.1371/journal.pone.0073085
  • Peer Reviewed
• [Journal Article] Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary. (2013)
  • Author(s): Halimi SA, Maeda D, Shinozaki-Ushiku A, Koso T, Matsusaka K, Tanaka M, Arimoto T, Oda K, Kawana K, Yano T, Fujii T, Fukayama M
  • Journal Title: Histopathology Volume: 63 Issue: 4 Pages: 534-544
  • DOI: 10.1111/his.12182
  • Peer Reviewed
• [Journal Article] The Prevalence Of Cervical Regulatory T Cells in HPV-Related Cervical Intraepithelial Neoplasia (CIN) Correlates Inversely with Spontaneous Regression of CIN (2013)
  • Author(s): Kojima S, Kawana K, Tomio K, Yamashita A, Taguchi A, Nagamatsu T, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, Wada-Hiraike O, Yano T, Taketani Y, Fujii T, Schust DJ, Kozuma S
  • Journal Title: Am J Reprod Immunol, Volume: 69 Issue: 2 Pages: 134
  • DOI: 10.1111/aji.12030
  • URL: https://pure.teikyo.jp/en/publications/57ac5306-26d0-4646-ad14-8521673ad284
  • Peer Reviewed
• [Journal Article] Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth (2013)
  • Author(s): Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 3113-3113
  • DOI: 10.1038/srep03113
  • Peer Reviewed
• [Journal Article] Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair (2013)
  • Author(s): Tanikawa, M., Wada-Hiraike, O., Yoshizawa-Sugata, N., Shirane A, Hirano M, Hiraike H, Miyamoto, Y., Sone, K., Ikeda, Y., Kashiyama, T., Oda K, Kawana K, Katakura Y, Yano T, Masai, H., Roy AL, Osuga, Y. and Fujii, T.
  • Journal Title: Br. J. Cancer. Volume: 109 Issue: 12 Pages: 3042
  • DOI: 10.1038/bjc.2013.532
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genome wide association stu (2013)
  • Author(s): Tanikawa C, Okada Y, Takahashi A, Oda K, Kamatani N, Kubo M, Nakamura Y, Matsuda K
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Mechanism of transition to invasive cancer, on basis of genomic instability and genetic alterations, and identification of a novel biomarker to predict poor prognosis in endometrial carcinomas (2013)
  • Author(s): Oda K
  • Journal Title: Acta Obst Gynaec Jpn Volume: 65 Pages: 2388-2401
• [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: An implicative role of SIRT1 in the ovary (2012)
  • Author(s): Y.Morita, K.Tsutsui, et al
  • Journal Title: Reprod.Biol.Endocrinbl. Volume: 10 Issue: 1 Pages: 14-24
  • DOI: 10.1186/1477-7827-10-14
  • Peer Reviewed
• [Journal Article] Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer. (2012)
  • Author(s): Ikeda Y, Oda K, Nakagawa S
  • Journal Title: Int J Gynecol Cancer Volume: 22(5） Issue: 5 Pages: 725-31
  • DOI: 10.1097/igc.0b013e31824c6ea6
  • Peer Reviewed
• [Journal Article] Genotype-dependent efficacy of a Dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas (2012)
  • Author(s): Shoji K, Oda K, Nakagawa S,-Hiraike O, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y.
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e37431-e37431
  • DOI: 10.1371/journal.pone.0037431
  • Peer Reviewed
• [Journal Article] Second-line chemotherapy with docetaxel and carboplatin in paclitaxel and platinum-pretreated ovarian, fallopian tube, and peritoneal cancer. (2012)
  • Author(s): Arimoto T, Nakagawa S, Oda K et al
  • Journal Title: Med Oncol Volume: 29 Issue: 2 Pages: 1253-1254
  • DOI: 10.1007/s12032-011-9878-z
  • Peer Reviewed
• [Journal Article] Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer. (2012)
  • Author(s): Ikeda Y, Oda K, Nakagawa S, Murayama Hosokawa S et al
  • Journal Title: Int J Gynecol Cancer Volume: 22 Issue: 2 Pages: 725-731
  • DOI: 10.1097/igc.0b013e31827de69e
  • Peer Reviewed
• [Journal Article] 抗癌剤化学療法の妊孕能への影響 (2012)
  • Author(s): 織田克利,池田悠至
  • Journal Title: 産婦人科の実際 Volume: 61(12) Pages: 1919-1925
• [Journal Article] Ras-PI3K経路を標的とした選択的p110阻害剤による抗腫瘍効果の解析 (2012)
  • Author(s): 織田克利
  • Journal Title: 産科と婦人科 Volume: 79(2)
• [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. (2012)
  • Author(s): Morita Y, Wada-Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, Koyama S, Oishi H, Yoshino O, Miyamoto Y, Sone K, Oda K et al
  • Journal Title: Reprod Biol Endocrinol Volume: 10
  • Peer Reviewed
• [Journal Article] Low-grade endometrial stromal sarcoma developing in a postmenopausal woman under toremifene treatment for breast cancer (2012)
  • Author(s): Kashiyama T, Oda K et al
  • Journal Title: J Obstet Gynaecol Res Volume: 38
  • Peer Reviewed
• [Journal Article] Retreatment with nedaplatin in patients with recurrent gynecological cancer after the development of hypersensitivity reaction to carboplatin (2012)
  • Author(s): Takahide A, Oda K et al
  • Journal Title: J Obstet Gynaecol Res Volume: 38
  • Peer Reviewed
• [Journal Article] Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer (2012)
  • Author(s): Ikeda Y, Oda K et al
  • Journal Title: Int J Gynecol Cancer Volume: 22
  • Peer Reviewed
• [Journal Article] Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas (2012)
  • Author(s): Shoji K, Oda K et al
  • Journal Title: PLos ONE Volume: 7
  • Peer Reviewed
• [Journal Article] 若手の最新研究紹介コーナー Ras-PI3K経路を標的とした選択的p110阻害剤による抗腫瘍効果の解析 (2012)
  • Author(s): 織田克利
  • Journal Title: 産科と婦人科 Volume: 79 Pages: 95-97
• [Journal Article] Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma : a case report (2011)
  • Author(s): Shoji K, Oda K, et al
  • Journal Title: Med Oncol Volume: 28 Issue: 3 Pages: 771-774
  • DOI: 10.1007/s12032-010-9511-6
  • Peer Reviewed
• [Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function (2011)
  • Author(s): Tanikawa M, Wada Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, et al
  • Journal Title: Br J Cancer Volume: 104 Issue: 8 Pages: 1349
  • DOI: 10.1038/bjc.2011.75
  • Peer Reviewed
• [Journal Article] B-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors (2011)
  • Author(s): Maeda D, Shibahara J, Sakuma T, Isobe M, Teshima S, Mori M, Oda K, Nakagawa S, Taketani Y, Ishikawa S, Fukayama M
  • Journal Title: Am J Surg Pathol Volume: 35 Issue: 10 Pages: 1429-1440
  • DOI: 10.1097/pas.0b013e31822d6c71
  • Peer Reviewed
• [Journal Article] 子宮体癌におけるRas-PI3K/mTOR経路を標的とした治療法とそのバイオマーカー (2011)
  • Author(s): 織田克利
  • Journal Title: 癌と化学療法 Volume: 38(7) Pages: 1084-1087
• [Journal Article] Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report. (2011)
  • Author(s): Shoji K, Oda K, Nakagawa S, Kawana K, Yasugi T, Ikeda Y, Takazawa Y, Kozuma S, Taketani Y
  • Journal Title: Med Oncol Volume: 28 Pages: 771-774
  • Peer Reviewed
• [Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function. (2011)
  • Author(s): Tanikawa M, Wada Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K et al
  • Journal Title: Br J Cancer Volume: 104 Pages: 1349-1355
  • Peer Reviewed
• [Journal Article] β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors. (2011)
  • Author(s): Maeda D, Shibahara J, Sakuma T, Isobe M, Teshima S, Mori M, Oda K et al
  • Journal Title: Am J Surg Pathol Volume: 35 Pages: 1349-1355
  • Peer Reviewed
• [Journal Article] 婦人科系がんにおけるゲノム解読(TCGAの成果も含む)
  • Author(s): 織田克利
  • Journal Title: 実験医学増刊 Volume: (in press)
• [Presentation] 新規PI3K/mTOR同時阻害剤DS-7423は卵巣明細胞腺癌においてp53依存性アポトーシスを誘導する (2014)
  • Author(s): 樫山 智子, 織田 克利, 池田悠至, 塩瀬能伸, 廣田泰秀, 宮坂亞希, 福田友彦, 稲葉可奈子, 庄司恵子, 平池修, 川名敬, 矢野哲, 藤井知行, 上妻志郎
  • Organizer: 第13回婦人科がん分子標的研究会
  • Place of Presentation: 鳥取
• [Presentation] Perspective on molecu lar targeted therapy for endometrial cancer (2013)
  • Author(s): Katsutoshi Oda
  • Organizer: The 3rd Biennial Meeting of ASGO & 55th Meeting of JSGO
  • Year and Date: 2013-12-14
• [Presentation] 卵巣明細胞腺癌の統合的ゲノム解析 (2013)
  • Author(s): 神尊貴裕、織田克利, 他
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-04
• [Presentation] 卵巣明細胞腺癌と腎明細胞腺癌におけるゲノム異常様式の類似・相違点の解明 (2013)
  • Author(s): 浅田佳代、神尊貴裕、織田克利, 他
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-04
• [Presentation] 子宮体がんにおいてMAPK経路は治療ターゲットとなりうる (2013)
  • Author(s): 稲葉可奈子、織田克利, 他
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-03
• [Presentation] Comparison of genomic alteration patt erns between ovarian clear cell carcinoma and renal cell carcinoma (2013)
  • Author(s): Kayo Asada, Takahiro Koso, Katsutoshi Oda , et al
  • Organizer: AACR (Advances in Ovarian Cancer Research)
  • Place of Presentation: Miami, FL, USA
  • Year and Date: 2013-09-19
• [Presentation] 子宮体癌へのPARP阻害剤の有効性の検討 (2013)
  • Author(s): 宮坂亞希、織田克利, 他
  • Organizer: 第12回婦人科がん分子標的研究会
  • Place of Presentation: 奈良
  • Year and Date: 2013-07-05
• [Presentation] サイクリンD依存性キナーゼ比活性値は子宮体癌における予後予測の新規バイオマーカーである (2013)
  • Author(s): 池田悠至、織田克利, 他
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
  • Year and Date: 2013-05-10
• [Presentation] Induction of apoptosis in ovarian clear cell carcinomas with wild-type TP53 by inhibiting PI3K/mTOR signaling pathway (2013)
  • Author(s): Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Yoshinobu Shiose, Yasuhide Hirora, Aki Miyasaka, Takahiro Koso, Kanako Inaba, Tomohiko Fukuda, Keiko Shoji, Michihiro Tanikawa, Kazunori Nagasaka, Osamu Hiraike-Wada, Kei Kawana, Hiroyuki Aburatani, Shunsuke Nakagawa, Tomoyuki Fujii, Tetsu Yano, Shiro Kozuma
  • Organizer: 104th AACR (American Association for Cancer Research) annual meeting,2013
  • Place of Presentation: Washington DC, USA
• [Presentation] Cyclin D1 harboring T286I mutation promotes oncogenic activation in endometrial cancer. (2013)
  • Author(s): Yuji Ikeda, Katsutoshi Oda, Takahiro Koso, Aki Miyasaka, Tomoko Kashiyama, Osamu Hiraike-Wada, Daichi Maeda, Kei Kawana, Shunsuke Nakagawa, Osamu Tetsu, Yoshihiro Kikuchi, Tomoyuki Fujii, Tetsu Yano, Shiro Kozuma
  • Organizer: 104th AACR (American Association for Cancer Research) annual meeting,2013
  • Place of Presentation: Washington DC, USA
• [Presentation] シンポジウム1（腫瘍） 婦人科癌の浸潤・転移機構の解明と臨床応用： ゲノム不安定性・遺伝子変異に基づく子宮体癌の浸潤能獲得と分子生物学的予後不良因子の検討 (2013)
  • Author(s): 織田 克利
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 卵巣低悪性度奬液性腺癌の臨床像 (2013)
  • Author(s): 松村 慶子, 織田 克利, 神尊 貴裕, 有本 貴英, 松本 陽子, 長阪 一憲, 三浦 紫保, 佐藤 英貴, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 新規PI3K/mTOR同時阻害剤DS-7423は卵巣明細胞腺癌において腫瘍増殖を抑制しp53依存性アポトーシスを誘導する (2013)
  • Author(s): 樫山 智子, 織田 克利, 池田 悠至, 宮坂 亞希, 福田 友彦, 稲葉 可奈子, 庄司 恵子, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 抗マラリア薬クロロキンは子宮体癌の新規抗がん剤となりうる (2013)
  • Author(s): 福田 友彦, 織田 克利, 樫山 智子, 宮坂 亞希, 稲葉 可奈子, 神尊 貴裕, 池田 悠至, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 子宮体癌においてMAPK経路は治療ターゲットとなりうる (2013)
  • Author(s): 稲葉 可奈子, 織田 克利, 福田 友彦, 宮坂 亞希, 樫山 智子, 池田 悠至, 蔵本 博行, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 子宮体癌に対するPARP阻害剤Olaparibの有効性の検討 (2013)
  • Author(s): 宮坂 亞希, 織田 克利, 池田 悠至, 稲葉 可奈子, 福田 友彦, 神尊 貴裕, 蔵本 博行, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 40歳以上の卵巣悪性胚細胞腫瘍の臨床像の検討 (2013)
  • Author(s): 南川麻里, 織田克利, 有本貴英, 曾根献文, 前田大地, 松本陽子, 長阪一憲, 三浦紫保, 佐藤英貴, 上原ゆり子, 宮本雄一郎, 川名敬, 藤井知行, 上妻志郎
  • Organizer: 第54回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 東京
• [Presentation] 子宮体癌へのPARP阻害剤Olaparibの有効性の検討 (2013)
  • Author(s): 宮坂亞希, 織田克利, 池田悠至, 樫山智子, 稲葉可奈子, 福田友彦, 神尊貴裕, 蔵本博行, 平池修, 川名敬, 矢野哲, 藤井知行, 上妻志郎
  • Organizer: 第12回婦人科がん分子標的研究会
  • Place of Presentation: 奈良
• [Presentation] Comparison of genomic alteration patterns between ovarian clear cell carcinoma and renal cell carcinoma (2013)
  • Author(s): Kayo Asada, Takahiro Koso, Katsutoshi Oda, Yuriko Uehara, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Reiko Kurikawa, Yuji Ikeda, Osamu Hiraike, Kei Kawana, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii, Hiroyuki Aburatani
  • Organizer: AACR Special Conference: Advances in Ovarian Cancer Research: From Concept to Clinic
  • Place of Presentation: Miami, FL, USA
• [Presentation] Perspective on molecular targeted therapy for endometrial cancer. (2013)
  • Author(s): Katsutoshi Oda
  • Organizer: The 3rd Biennial Meeting of ASGO & the 55th Meeting of JSGO
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] A novel diagnostic approach using genome-wide single nucleotide polymorphism arrays (2012)
  • Author(s): Yuji Ikeda, Katsutoshi Oda, Shunsuke Nakagawa, Satsuki Murayama Hosokawa et al
  • Organizer: 2012 American Association for Cancer Research Annual Meeting
  • Place of Presentation: Chicago, IL, USA
• [Presentation] 子宮体部・卵巣類内膜腺癌における染色体不安定性と臨床診断への応用に関する検討 (2012)
  • Author(s): 織田 克利, 上原 ゆり子, 細川 さつき 他
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 子宮体癌におけるCyclin D1変異体は核内蓄積により細胞増殖を促進する (2012)
  • Author(s): 池田 悠至, 織田 克利, 神尊 貴裕 他
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 子宮体癌治療の合併症から見た後療法の再考 (2012)
  • Author(s): 有本 貴英, 織田 克利, 川名 敬 他
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 卵巣類内膜腺癌に特徴的な遺伝子発現プロファイルは予後良好と相関する (2012)
  • Author(s): 神尊 貴裕, 織田 克利, 上原 ゆり子 他
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 染色体コピー数と発現アレイ解析に基づく卵巣明細胞癌における予後不良群の同定 (2012)
  • Author(s): 上原 ゆり子, 織田 克利, 中川 俊介 他
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] 卵巣明細胞腺癌細胞株におけるPI3K-AKT経路の遺伝子変異と活性化に関する検討 (2012)
  • Author(s): 樫山 智子, 織田 克利, 中川 俊介 他
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] Effect of weekly administration of bevacizumab, gemcitabine and oxalilplatin (2012)
  • Author(s): Yuji Ikeda, Yoshihiro Kikuchi, Masashi Takano, Katsutoshi Oda et al
  • Organizer: 2012 ASCO (American Society of Clinical Oncology) Annual Meeting
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Anti-tumor efficacy of DS-7423, novel PI3K/mTOR dual inhibitor, in ovarian clear cell adenocarcinoma (2012)
  • Author(s): Tomoko Kashiyama, Katsutoshi Oda et al
  • Organizer: 24th EORTC-NCI-AACR Symposium on 'Molecular Targets and Cancer Therapeutics'
  • Place of Presentation: Dublin, Ireland
• [Presentation] 子宮体癌株におけるPARP阻害剤オラパリブの抗腫瘍効果 (2012)
  • Author(s): 宮坂 亞希、織田 克利 他
  • Organizer: 第71回癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Phosphorylation of HER2 might be a useful biomarker to predict sensitivities to HER2-targeted therapy in ovarian clear cell adenocarcinomas. (2012)
  • Author(s): Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Aki Miyasaka, Takahiro Koso, Tomohiko Fukuda
  • Organizer: 第71回癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] K-Ras変異を有する子宮体癌におけるPI3K/mTOR阻害剤とMEK阻害剤併用の効果の検討 (2011)
  • Author(s): 樫山智子、織田克利 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] PI3K-Akt/mTOR経路を標的とした子宮体癌における分子標的治療戦略 (2011)
  • Author(s): 庄司恵子, 織田克利 他
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
• [Presentation] SNP(single nucleotide polymorphism)Typing Arrayを用いたゲノム解析による子宮体部・卵巣同時発生癌の新たな診断方法 転移か、同時発生原発癌か (2011)
  • Author(s): 池田悠至, 織田克利 他
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 子宮・両側付属器摘出後のエストロゲン単独補充療法中に診断された類内膜腺癌の2例 (2011)
  • Author(s): 樋口紗恵子, 織田克利 他
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 子宮体癌において発見された変異型β-カテニンの機能解析 (2011)
  • Author(s): 池田悠至, 織田克利 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 子宮体癌におけるPI3K/mTOR経路阻害剤とMAPK経路阻害剤の併用療法による抗腫瘍効果の検討 (2011)
  • Author(s): 樫山智子, 織田克利 他
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 上皮性卵巣癌におけるBRCA1/2を含む癌抑制遺伝子の染色体欠失領域(Loss of Heterozygosity;LOH)の同定 (2011)
  • Author(s): 織田克利 他
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 卵巣実質に転移もしくは重複癌が認められた子宮体部類内膜腺癌27例における予後因子の検討 (2011)
  • Author(s): 武家尾舞子, 織田克利 他
  • Organizer: 第50回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 卵巣病変の有無に着目した子宮体癌III/IV期における予後因子の検討 (2011)
  • Author(s): 武家尾舞子, 織田克利 他
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 卵巣類内膜腺癌におけるをBRCA1/2含む癌抑制遺伝子の染色体欠失領域(Loss of Heterozygosity; LOH) の同定 (2011)
  • Author(s): 宮坂亞希、織田克利 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] In vivo antitumor activity of NVP-BEZ235, a dual PI3K/mTOR inhibitor, and RAD001 (everolimus), an mTOR inhibitor, in endometrial cancer (2011)
  • Author(s): Keiko Shoji, Katsutoshi Oda et al
  • Organizer: 102nd AACR Annual Meeting
  • Place of Presentation: Orland, FL, USA
• [Presentation] Mutations of Cyclin D1 / beta-catenin are coexistent with mutations in Ras-PI3K pathway genes in endometrial cancer (2011)
  • Author(s): Yuji Ikeda, Katsutoshi Oda et al
  • Organizer: 102nd AACR (American Association for Cancer Research) Annual Meeting
  • Place of Presentation: Orland, FL, USA
• [Presentation] Genome-wide single nucleotide polymorphism (SNP) arrays as a novel diagnostic tool in synchronous carcinomas. (2011)
  • Author(s): Yuji Ikeda, Katsutoshi Oda et al
  • Organizer: 2011 ASCO (American Society of Clinical Oncology) Annual Meeting
  • Place of Presentation: Chicago, IL, USA
• [Book] 外陰炎、外陰潰瘍、外陰がん.今日の治療と看護改訂第3版 (2013)
  • Author(s): 織田克利
• [Book] 腟炎、子宮頸管炎.今日の治療と看護改訂第3版 (2013)
  • Author(s): 織田克利
• [Book] 産婦人科の実際 (2013)
  • Author(s): 織田克利
  • Publisher: 子宮体癌に対する分子標的治療の展望
• [Book] 今日の治療と看護 (2013)
  • Author(s): 織田克利
  • Publisher: 外陰炎、外陰潰瘍、外陰がん
• [Book] 今日の治療と看護 (2013)
  • Author(s): 織田克利
  • Publisher: 腟炎、子宮頸管炎
• [Book] 産婦人科の実際 (2012)
  • Author(s): 織田 克利, 池田 悠至
  • Publisher: 【妊孕能を考える】 抗癌剤化学療法の妊孕能への影響