Development of molecular targeted therapeutics and its biomarkers in endometrial and ovarian clear cell carcinomas
Project/Area Number |
23592437
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | The University of Tokyo |
Principal Investigator |
ODA Katsutoshi 東京大学, 医学部附属病院, 准教授 (30359608)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 子宮体癌 / 卵巣癌 / 分子標的治療 / ゲノム解析 / バイオマーカー / PI3K / cyclin D1 / DNA修復 / PI3K / TP53 / アポトーシス / 遺伝子変異 / 卵巣明細胞腺癌 / Ras / 染色体コピー数異常 / マイクロサテライト不安定性 / 転移 / 診断的バイオマーカー / PI3K経路 / mTOR / PIK3CA / PTEN |
Research Abstract |
We elucidated a novel molecular targeted therapeutics and its predictive biomarkers in endometrial and ovarian clear cell adenocarcinomas, on basis of the aberrant signaling pathways in these cancers. 1. We found that a PI3K pathway inhibitor (dual PI3K/mTOR inhibitor) is effective in endometrial and ovarian clear cell adenocarcinomas. Furthermore, mutational status of KRAS and TP53 was indicated as predictive biomarkers to the PI3K/mTOR inhibitor. 2. We revealed that genome-wide analyses, including single nucleotide polymorphism arrays, are useful for both diagnosis and prediction of prognosis in synchronous endometrial and ovarian carcinomas. In addition, we reported that activation of cyclin D1 and disruption of DNA repair pathways play important roles in endometrial cancer.
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Report
(4 results)
Research Products
(90 results)
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[Journal Article] Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells.2014
Author(s)
A. Miyasaka, K. Oda, Y. Ikeda, O. Wada-Hiraike, T. Kashiyama, A. Enomoto, N. Hosoya, T. Koso, T. Fukuda, K. Inaaba, K. Sone, Y. Uehara, R. Kurikawa, K. Nagasaka, Y.Matsumoto, T. Arimoto, S. Nakagawa, H. Kuramoto, K. Miyagawa, T. Yano, K. Kawana, Y. Osuga, T. Fujii.
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Journal Title
BMC Cancer
Volume: -
Issue: 1
Pages: 179-179
DOI
Related Report
Peer Reviewed
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[Journal Article] Antitumor Activity and Induction of TP53-Dependent Apoptosis toward Ovarian Clear Cell Adenocarcinoma by the Dual PI3K/mTOR Inhibitor DS-7423.2014
Author(s)
Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Nakagawa S, Matsuda K, McCormick F, Aburatani H, Yano T, Osuga Y, Fujii T
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e87220-e87220
DOI
Related Report
Peer Reviewed
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[Journal Article] High-risk HPV correlates with recurrence after laser ablation for treatment of patients with CIN3: a long-term follow-up retrospective study,2014
Author(s)
Inaba K, Nagasaka K, Kawana K, Arimoto T, Matsumoto Y, Tsuruga T, Mori-Uchino M, Miura S, Sone K, Oda K, Nakagawa S, Yano T, Kozuma S, Fujii T
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Journal Title
J Obstet Gynaecol Res
Volume: 40
Issue: 2
Pages: 554-60
DOI
Related Report
Peer Reviewed
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[Journal Article] Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyusaturated fatty acids in vitro and in vivo.2014
Author(s)
Taguchi A, Kawana K, Tomio K, Yamashita A, Isobe Y, Nagasaka K, Koga K, Inoue T, Nishida H, kojima S, Adachi K, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, kang JX, Arai H, Arita M, Osuga Y, Fujii T.
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Journal Title
PLoS One
Volume: 27
Issue: 2
Pages: e89605-e89605
DOI
Related Report
Peer Reviewed
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[Journal Article] Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines.2013
Author(s)
Miyamoto Y, Nakagawa S, Wada-Hiraike O, Seiki T, Tanikawa M, Hiraike H, Sone K, Nagasaka K, Oda K, Kawana K, Nakagawa K, Fujii T, Yano T, Kozuma S, Taketani Y.
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Journal Title
Oncol Rep.
Volume: 29(1)
Issue: 1
Pages: 51-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer.2013
Author(s)
Ikeda Y, Oda K, Hiraike-Wada O, Koso T, Miyasaka A, Kashiyama T, Tanikawa M, Sone K, Nagasaka K, Maeda D, Kawana K, Nakagawa S, Fukayama M, Tetsu O, Fujii T, Yano T, Kozuma S
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Journal Title
Oncol Rep
Volume: 30
Issue: 2
Pages: 584-588
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Omega-3 polyunsaturated fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models.2013
Author(s)
Tomio K, Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.
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Journal Title
PLoS One
Volume: 8
Issue: 9
Pages: 2013-2013
DOI
Related Report
Peer Reviewed
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[Journal Article] Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary.2013
Author(s)
Halimi SA, Maeda D, Shinozaki-Ushiku A, Koso T, Matsusaka K, Tanaka M, Arimoto T, Oda K, Kawana K, Yano T, Fujii T, Fukayama M
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Journal Title
Histopathology
Volume: 63
Issue: 4
Pages: 534-544
DOI
Related Report
Peer Reviewed
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[Journal Article] The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN2013
Author(s)
Kojima S, Kawana K, Tomio K, Yamashita A, Taguchi A, Nagamatsu T, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, Wada-Hiraike O, Yano T, Taketani Y, Fujii T, Schust DJ, Kozuma S
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Journal Title
Am J Reprod Immunol,
Volume: 69
Issue: 2
Pages: 134-144
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased tissue level of omega-3 polyunsaturated fatty acids prevents pathological preterm birth.2013
Author(s)
Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.
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Journal Title
Sci Rep
Volume: 3
Issue: 1
Pages: 3113-3113
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair.2013
Author(s)
Tanikawa, M., Wada-Hiraike, O., Yoshizawa-Sugata, N., Shirane A, Hirano M, Hiraike H, Miyamoto, Y., Sone, K., Ikeda, Y., Kashiyama, T., Oda K, Kawana K, Katakura Y, Yano T, Masai, H., Roy AL, Osuga, Y. and Fujii, T.
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Journal Title
Br. J. Cancer.
Volume: 109
Issue: 12
Pages: 3042-3048
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.2012
Author(s)
Shoji K, Oda K, Nakagawa S,-Hiraike O, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y.
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Journal Title
PLoS One
Volume: 7(5):
Issue: 5
Pages: e37431-e37431
DOI
Related Report
Peer Reviewed
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[Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary.2012
Author(s)
Morita Y, Wada-Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, Koyama S, Oishi H, Yoshino O, Miyamoto Y, Sone K, Oda K et al
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Journal Title
Reprod Biol Endocrinol
Volume: 10
Related Report
Peer Reviewed
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[Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function2011
Author(s)
Tanikawa M, Wada Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, et al
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Journal Title
Br J Cancer
Volume: 104
Issue: 8
Pages: 1349-1355
DOI
Related Report
Peer Reviewed
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[Journal Article] B-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors2011
Author(s)
Maeda D, Shibahara J, Sakuma T, Isobe M, Teshima S, Mori M, Oda K, Nakagawa S, Taketani Y, Ishikawa S, Fukayama M
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Journal Title
Am J Surg Pathol
Volume: 35
Issue: 10
Pages: 1429-1440
DOI
Related Report
Peer Reviewed
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[Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function.2011
Author(s)
Tanikawa M, Wada Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K et al
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Journal Title
Br J Cancer
Volume: 104
Pages: 1349-1355
Related Report
Peer Reviewed
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[Presentation] 新規PI3K/mTOR同時阻害剤DS-7423は卵巣明細胞腺癌においてp53依存性アポトーシスを誘導する2014
Author(s)
樫山 智子, 織田 克利, 池田悠至, 塩瀬能伸, 廣田泰秀, 宮坂亞希, 福田友彦, 稲葉可奈子, 庄司恵子, 平池修, 川名敬, 矢野哲, 藤井知行, 上妻志郎
Organizer
第13回婦人科がん分子標的研究会
Place of Presentation
鳥取
Related Report
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[Presentation] Induction of apoptosis in ovarian clear cell carcinomas with wild-type TP53 by inhibiting PI3K/mTOR signaling pathway2013
Author(s)
Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Yoshinobu Shiose, Yasuhide Hirora, Aki Miyasaka, Takahiro Koso, Kanako Inaba, Tomohiko Fukuda, Keiko Shoji, Michihiro Tanikawa, Kazunori Nagasaka, Osamu Hiraike-Wada, Kei Kawana, Hiroyuki Aburatani, Shunsuke Nakagawa, Tomoyuki Fujii, Tetsu Yano, Shiro Kozuma
Organizer
104th AACR (American Association for Cancer Research) annual meeting,2013
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] Cyclin D1 harboring T286I mutation promotes oncogenic activation in endometrial cancer.2013
Author(s)
Yuji Ikeda, Katsutoshi Oda, Takahiro Koso, Aki Miyasaka, Tomoko Kashiyama, Osamu Hiraike-Wada, Daichi Maeda, Kei Kawana, Shunsuke Nakagawa, Osamu Tetsu, Yoshihiro Kikuchi, Tomoyuki Fujii, Tetsu Yano, Shiro Kozuma
Organizer
104th AACR (American Association for Cancer Research) annual meeting,2013
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] 卵巣低悪性度奬液性腺癌の臨床像2013
Author(s)
松村 慶子, 織田 克利, 神尊 貴裕, 有本 貴英, 松本 陽子, 長阪 一憲, 三浦 紫保, 佐藤 英貴, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
Organizer
第65回日本産科婦人科学会学術講演会
Place of Presentation
札幌
Related Report
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[Presentation] 新規PI3K/mTOR同時阻害剤DS-7423は卵巣明細胞腺癌において腫瘍増殖を抑制しp53依存性アポトーシスを誘導する2013
Author(s)
樫山 智子, 織田 克利, 池田 悠至, 宮坂 亞希, 福田 友彦, 稲葉 可奈子, 庄司 恵子, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
Organizer
第65回日本産科婦人科学会学術講演会
Place of Presentation
札幌
Related Report
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[Presentation] 抗マラリア薬クロロキンは子宮体癌の新規抗がん剤となりうる2013
Author(s)
福田 友彦, 織田 克利, 樫山 智子, 宮坂 亞希, 稲葉 可奈子, 神尊 貴裕, 池田 悠至, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
Organizer
第65回日本産科婦人科学会学術講演会
Place of Presentation
札幌
Related Report
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[Presentation] 子宮体癌においてMAPK経路は治療ターゲットとなりうる2013
Author(s)
稲葉 可奈子, 織田 克利, 福田 友彦, 宮坂 亞希, 樫山 智子, 池田 悠至, 蔵本 博行, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
Organizer
第65回日本産科婦人科学会学術講演会
Place of Presentation
札幌
Related Report
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[Presentation] 子宮体癌に対するPARP阻害剤Olaparibの有効性の検討2013
Author(s)
宮坂 亞希, 織田 克利, 池田 悠至, 稲葉 可奈子, 福田 友彦, 神尊 貴裕, 蔵本 博行, 平池 修, 川名 敬, 藤井 知行, 矢野 哲, 上妻 志郎
Organizer
第65回日本産科婦人科学会学術講演会
Place of Presentation
札幌
Related Report
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[Presentation] 40歳以上の卵巣悪性胚細胞腫瘍の臨床像の検討2013
Author(s)
南川麻里, 織田克利, 有本貴英, 曾根献文, 前田大地, 松本陽子, 長阪一憲, 三浦紫保, 佐藤英貴, 上原ゆり子, 宮本雄一郎, 川名敬, 藤井知行, 上妻志郎
Organizer
第54回日本婦人科腫瘍学会学術講演会
Place of Presentation
東京
Related Report
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[Presentation] 子宮体癌へのPARP阻害剤Olaparibの有効性の検討2013
Author(s)
宮坂亞希, 織田克利, 池田悠至, 樫山智子, 稲葉可奈子, 福田友彦, 神尊貴裕, 蔵本博行, 平池修, 川名敬, 矢野哲, 藤井知行, 上妻志郎
Organizer
第12回婦人科がん分子標的研究会
Place of Presentation
奈良
Related Report
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[Presentation] Comparison of genomic alteration patterns between ovarian clear cell carcinoma and renal cell carcinoma2013
Author(s)
Kayo Asada, Takahiro Koso, Katsutoshi Oda, Yuriko Uehara, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Reiko Kurikawa, Yuji Ikeda, Osamu Hiraike, Kei Kawana, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii, Hiroyuki Aburatani
Organizer
AACR Special Conference: Advances in Ovarian Cancer Research: From Concept to Clinic
Place of Presentation
Miami, FL, USA
Related Report
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