| Project/Area Number |
23592448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHINO Kiyoshi 大阪大学, 医学(系)研究科(研究院), 講師 (90362730)
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Takayuki 大阪大学, 医学(系)研究科(研究院), 教授 (90283754)
FUJITA Masami 大阪大学, 医学(系)研究科(研究院), 講師 (60303963)
UEDA Yutaka 大阪大学, 医学(系)研究科(研究院), 助教 (10346215)
KIMURA Toshihiro 大阪大学, 医学部附属病院, 助教 (90584524)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Masahiro (10342990)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 婦人科腫瘍学 / 初代培養 / 子宮体癌 / 漿液性腺癌 / 薬剤感受性 / ３次元培養 / CTOS / spheroid / 婦人科腫瘍 / 感受性 / バイオマーカー / Nf-kB / Type II / 子宮頸癌 / 卵巣癌 / 抗癌剤感受性 |
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| Research Abstract |
Drug sensitivity test for the patient of gynecology cancer by checking beforehand may give a merit. The aim of this study is establishment of a drug sensitivity examination using CTOS (cancer tissue-originated spheroid) which cultured the cancer cell extracted by an operation. As a result, it was revealed that among endometrial cancer, CTOS derived from the serous adenocarcinoma was prepared and maintained with high success rate. In addition, among the drugs which inhibit a signal related cancer growth, mTOR inhibitor, NF-kB inhibitor showed moderate activity.
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