Establishment and application of cancer-tissue originated spheroids(CTOSs) of gynecologic cancer
Project/Area Number |
23592448
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Osaka University |
Principal Investigator |
YOSHINO Kiyoshi 大阪大学, 医学(系)研究科(研究院), 講師 (90362730)
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Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Takayuki 大阪大学, 医学(系)研究科(研究院), 教授 (90283754)
FUJITA Masami 大阪大学, 医学(系)研究科(研究院), 講師 (60303963)
UEDA Yutaka 大阪大学, 医学(系)研究科(研究院), 助教 (10346215)
KIMURA Toshihiro 大阪大学, 医学部附属病院, 助教 (90584524)
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Co-Investigator(Renkei-kenkyūsha) |
INOUE Masahiro (10342990)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 婦人科腫瘍学 / 初代培養 / 子宮体癌 / 漿液性腺癌 / 薬剤感受性 / 3次元培養 / CTOS / spheroid / 婦人科腫瘍 / 感受性 / バイオマーカー / Nf-kB / Type II / 子宮頸癌 / 卵巣癌 / 抗癌剤感受性 |
Research Abstract |
Drug sensitivity test for the patient of gynecology cancer by checking beforehand may give a merit. The aim of this study is establishment of a drug sensitivity examination using CTOS (cancer tissue-originated spheroid) which cultured the cancer cell extracted by an operation. As a result, it was revealed that among endometrial cancer, CTOS derived from the serous adenocarcinoma was prepared and maintained with high success rate. In addition, among the drugs which inhibit a signal related cancer growth, mTOR inhibitor, NF-kB inhibitor showed moderate activity.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Second-line chemotherapy for advanced or recurrent endometrial carcinoma previously treated with paclitaxel and carboplatin, with or without epirubicin2011
Author(s)
Ueda, Y. Miyake, T. Egawa-Takata, T. Miyatake, T. Matsuzaki, S. Yokoyama, T. Yoshino, K. Fujita, M. Enomoto, T. Kimura, T
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Journal Title
Canc Chemot
Volume: 67(4)
Issue: 4
Pages: 829-35
DOI
Related Report
Peer Reviewed
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[Journal Article] Recurrent endometrial carcinoma : prognosis for patients with recurrence within six to twelve months is worse relative at 12 months or later2011
Author(s)
Miyake, T. Ueda, Y. Egawa-Takata, T. Matsuzaki, S. Yokoyama, T. Miyoshi, Y. Kimura, T. Yoshino, K. Fujita, M. Yamasaki, M. Enomoto, T. Kimura, T
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Journal Title
Am J Obstet Gynecol
Volume: 204(6)
Related Report
Peer Reviewed
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[Journal Article] Usefulness of computed tomography in predicting cytoreductive surgical outcomes for ovarian cancer2011
Author(s)
Fujiwara, K. Yoshino, K. Enomoto, T. Fujita, M. Ueda, Y. Miyatake, T. Kimura, T. Muraji, M. Fujita, H. Kimura, T. Hori, M
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Journal Title
Arch Gynecol Obstet
Volume: 284(6)
Issue: 6
Pages: 1501-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Second-line Chemotherapy for Advanced or Recurrent Endometrial Carcinoma Previously Treated with Paclitaxel and Carboplatin,with or without Epirubicin.2011
Author(s)
Ueda Y,Miyake T,Egawa-Takata T,Miyatake T,Matsuzaki S,Yokoyama T,Yoshino K,Fujita M,Enomoto T,Kimura T.
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Journal Title
Cancer Chemoth Pharm
Volume: 67(4)
Pages: 829-35
Related Report
Peer Reviewed
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[Journal Article] Recurrent endometrial carcinoma:Prognosis for patients with recurrence within six to twelve months is worse relative at 12 months or later.2011
Author(s)
Miyake T,Ueda Y,Egawa-Takata T,Matsuzaki S,Yokoyama T,Miyoshi Y,Kimura T,Yoshino K,Fujita M,Yamasaki M,Enomoto T,Kimura T.
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Journal Title
Am J Obstet Gynecol
Volume: 204(6)
Related Report
Peer Reviewed
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[Journal Article] Usefulness of computed tomography in predicting cytoreductive surgical outcomes for ovarian cancer.2011
Author(s)
Fujiwara K,Yoshino K,Enomoto T,Fujita M,Ueda Y,Miyatake T,Kimura T,Muraji M,Fujita H,Kimura T,Hori M.
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Journal Title
Arcd Gynecol Obstet
Volume: 284(6)
Pages: 1501-7
Related Report
Peer Reviewed
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[Journal Article] Metastatic Mucinous Adenocarcinoma of the Ovary Is Characterized by Advanced Patient Age, Small Tumor Size, and Elevated Serum CA125.2011
Author(s)
Maeda-Taniguchi M, Ueda Y, Miyake T, Miyatake T, Kimura T, Yoshino K, Fujita M, Wakasa T, Ohashi H, Morii E, Enomoto T, Kimura T.
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Journal Title
Gynecol Obstet Invest
Volume: 72(3)
Pages: 196-202
Related Report
Peer Reviewed
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[Journal Article] Dissection of unsuspicious para-aortic lymph nodes does not improve prognosis of advanced endometrial carcinoma with intra- or extra-abdominal metastasis.2011
Author(s)
Ueda, Y.,Okazawa, M., Enomoto, T., Egawa-Takata, T., Kimura, T., Yoshino K., Fujita, M., Ohta, Y., Kamiura, S., Kimura, T.
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Journal Title
Anticancer Res.
Volume: 31(12)
Pages: 4513-7
Related Report
Peer Reviewed
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[Journal Article] HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers.2011
Author(s)
Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.
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Journal Title
Cancer Res.
Volume: 71(21)
Pages: 6636-42
Related Report
Peer Reviewed
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[Presentation] Establishment of cancer-tissue originated spheroids (CTOSs) and chemo-sensitivity test for endometrial cancer2012
Author(s)
Kimura, T. Yoshino, K. Hiramatsu, K. Kiyohara, Y. Morimoto, A. Yokoyama, T. Kobayashi, E. Ueda, Y. Fujita, M. Inoue, M. Enomoto, T. Kimura, T
Organizer
The 103rd Annual Meeting American Association for Cancer Research
Place of Presentation
Chicago, U.S.A
Related Report
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[Presentation] Chemo-sensitivity test using cancer-tissue originated spheroids(CTOSs) of endometrial cancer2012
Author(s)
Kiyohara, Y. Kimura, T. Yoshino, K. Morimoto, A. Ueda, Y. Fujita, M. Inoue, M. Enomoto, T. Kimura, T
Organizer
The 14th Biennial Meeting of the International Gynecologic Cancer Society
Place of Presentation
Vancouver, Canada
Related Report
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