Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.
Project/Area Number |
23592450
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Shimane University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Kentaro 島根大学, 医学部, 講師 (70346401)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 子宮体癌 / ゲノムワイド / がん遺伝子 / がん抑制遺伝子 / 国際情報交換 / TypeII 体癌 / 遺伝子増幅 / 癌遺伝子 / 国際情報交流 |
Research Abstract |
We analyzed the genomes of uterine serous carcinoma samples to better understand the molecular genetic characteristics of this cancer. Whole-exome sequencing was performed on 10 uterine serous carcinomas and the matched normal blood or tissue samples. We found frequent somatic mutations in TP53 (81.6%), PIK3CA (23.7%), FBXW7 (19.7%), and PPP2R1A (18.4%) among the 76 uterine serous carcinomas examined. All nine serous carcinomas that had an associated serous endometrial intraepithelial carcinoma had concordant PIK3CA, PPP2R1A, and TP53 mutation status between uterine serous carcinoma and the concurrent serous endometrial intraepithelial carcinoma component. DNA copy number analysis revealed frequent genomic amplification of the CCNE1 locus and deletion of the FBXW7 locus. Nearly half of these uterine serous carcinomas (48%) harbored PIK3CA mutation and/or PIK3CA amplification.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] ESR1 gene amplification in endometrial carcinomas : A clinicopathological analysis2013
Author(s)
Rahman MT, Nakayama K, Rahman M, Ishikawa M, Katagiri H, Katagiri A, Ishibashi T, Sato E, Iida K, Nakayama N, Ishikawa N, Miyazaki K
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Journal Title
Anticancer Res
Volume: 33
Pages: 3775-3781
Related Report
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[Journal Article] KRAS and MAPK1 gene amplification in type II ovarian carcinomas2013
Author(s)
Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Sato E, Iida K, Nakayama N, Ishikawa N, Miyazaki K
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Journal Title
Int J Mol Sci
Volume: 14
Pages: 13748-13762
Related Report
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[Journal Article] PPP2R1A mutation is a rare event in ovarian carcinoma across histological subtypes2013
Author(s)
Rahman M, Nakayama K, Rahman MT, Nakayama N, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Otsuki Y, Nakayama S, Miyazaki K
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Journal Title
Anticancer Res
Volume: 33
Pages: 113-118
Related Report
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[Journal Article] Is ATP7B a predictive marker in patients with ovarian carcinoma treated with platinum-taxane combination chemotherapy?2013
Author(s)
Katagiri H, Nakayama K, Rahman MT, Rahman M, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama S, Otsuki Y, Miyazaki K
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Journal Title
Int J Gynecol Cancer
Volume: 23
Pages: 60-64
Related Report
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[Journal Article] KRAS and MAPK1 gene amplification in type II ovarian carcinomas.2013
Author(s)
Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Sato E, Iida K, Nakayama N, Ishikawa N, Miyazaki K.
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Journal Title
Int J Mol Sci.
Volume: 14
Pages: 13748-13762
Related Report
Peer Reviewed
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[Journal Article] Rahman MT, Nakayama K, Rahman M, Ishikawa M, Katagiri H, Katagiri A, Ishibashi T, Sato E, Iida K, Nakayama N, Ishikawa N, Miyazaki K.: ESR1 gene amplification in endometrial carcinomas: A clinicopathological analysis.2013
Author(s)
Rahman MT, Nakayama K, Rahman M, Ishikawa M, Katagiri H, Katagiri A, Ishibashi T, Sato E, Iida K, Nakayama N, Ishikawa N, Miyazaki K
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Journal Title
Anticancer Res.
Volume: 33
Pages: 3775-3781
Related Report
Peer Reviewed
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[Journal Article] Low expression of nucleus accumbens-associated protein 1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma2012
Author(s)
Nishi T, Maruyama R, Urano T, Nakayama N, Kawabata Y, Yano S, Yoshida M, Nakayama K, Miyazaki K, Takenaga K, Tanaka T, Tajima Y
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Journal Title
Pathol Int
Volume: 62
Pages: 802-810
Related Report
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[Journal Article] eM.: Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses2012
Author(s)
Kuhn E, Wu RC, Guan B, Wu G, Zhang J, Wang Y, Song L, Yuan X, Wei L, Roden RB, Kuo KT, Nakayama K, Clarke B, Shaw P, Olvera N, Kurman RJ, Levine DA, Wang TL, Shih I
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Journal Title
J Natl Cancer Inst
Volume: 104
Pages: 1503-1513
Related Report
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[Journal Article] Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer2012
Author(s)
Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama S, Otsuki S, Miyazaki K
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Journal Title
Am J Clin Pathol
Volume: 138
Pages: 535-544
Related Report
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[Journal Article] NAC1, a BTB/POZ protein overexpressed in uterine sarcomas2012
Author(s)
Rahman MT, Nakayama K, Ishikawa M, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Iida K, Yamada T, Miyazaki K
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Journal Title
Anticancer Res
Volume: 32
Pages: 3841-3845
Related Report
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[Journal Article] Gene amplification of ZNF217 located at chr20q13.2 is associated with lymph node metastasis in ovarian clear cell carcinoma2012
Author(s)
Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama N, Otsuki Y, Nakayama S, Miyazaki K
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Journal Title
Anticancer Res
Volume: 32
Pages: 3091-3095
Related Report
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[Journal Article] Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma2012
Author(s)
Rahman M, Nakayama K, Rahman MT, Nakayama N, Ishikawa M, Katagiri A, Iida K, Nakayama S, Otsuki Y, Shih IeM, Miyazaki K
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Journal Title
Hum Pathol
Volume: 43
Pages: 2197-2206
Related Report
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[Journal Article] Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas2012
Author(s)
Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama N, Otsuki Y, Nakayama S, Miyazaki K.:
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Journal Title
Br J Cancer
Volume: 107
Pages: 300-307
Related Report
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[Journal Article] Frequent loss of tumor suppressor ARID1A protein expression in adenocarcinomas/adenosquamous carcinomas of the uterine cervix2012
Author(s)
Katagiri A, Nakayama K, Rahman MT, Rahman M, Katagiri H, Ishikawa M, Ishibashi T, Iida K, Otsuki Y, Nakayama S, Miyazaki K
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Journal Title
Int J Gynecol Cancer
Volume: 22
Pages: 208-212
Related Report
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[Journal Article] Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma2012
Author(s)
Rahman MT, Nakayama K, Rahman M, Nakayama N, Ishikawa M, Katagiri A, Iida K, Nakayama S, Otsuki Y, Shih IeM, Miyazaki K
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Journal Title
Cancer
Volume: 118
Pages: 2846-2857
Related Report
Peer Reviewed
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[Journal Article] Loss of ARID1A expression is related to shorter progression-free survival and chemoresistance in ovarian clear cell carcinoma2012
Author(s)
Katagiri A, Nakayama K, Rahman MT, Rahman M, Katagiri H, Nakayama N Ishikawa M, Ishibashi T, Iida K, Otsuki Y, Nakayama S, Miyazaki K
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Journal Title
Mod Pathol
Volume: 25
Pages: 282-288
Related Report
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[Journal Article] Biological and clinical significance of NAC1 expression in cervical carcinomas : a comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas2012
Author(s)
Yeasmin S, Nakayama K, Rahman MT, Rahman M, Ishikawa M, Katagiri A, Iida K, Nakayama N, Otsuki Y, Kobayashi H, Nakayama S, Miyazaki K
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Journal Title
Hum Pathol
Volume: 43
Pages: 506-519
Related Report
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[Journal Article] Genome-wide analyses of uterine serous carcinoma identify pathway aberrations involvingcyclinE-Fbxw7, PI3K and p53.2012
Author(s)
Kuhn E, Wu RC, Wu G, Guan B, Zhang J, Wang Y, Song L,Yuan X, Wei Lei, Roden RBS, Kuo KT, Nakayama K, Clarke B,Shaw P, Olvera N, Levine DA, Kurman RJ, Wang TL, Shih IeM,
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Journal Title
J Natl Cancer Inst.
Volume: 19
Issue: 19
Pages: 1503-1513
DOI
Related Report
Peer Reviewed
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[Journal Article] NAC1, A BTB/POZ Protein Overexpressed in Uterine Sarcomas.2012
Author(s)
Rahman MT, Nakayama K, Ishikawa M, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Iida K, Yamada T, Miyazaki K.
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Journal Title
Anticancer Res.
Volume: 32
Pages: 3841-3845
Related Report
Peer Reviewed
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[Journal Article] Biological and clinical significance of NAC1 expression in cervical carcinomas: a comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas.2012
Author(s)
Yeasmin S, Nakayama K, Rahman MT, Rahman M, Ishikawa M, Katagiri A, Iida K, Nakayama N, Otuski Y, Kobayashi H, Nakayama S, Miyazaki K.
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Journal Title
Hum Pathol.
Volume: 43
Pages: 506-519
Related Report
Peer Reviewed
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[Journal Article] Loss of ARID1A expression is related to shorter progression-free survival and chemoresistance in ovarian clear cell carcinoma.2012
Author(s)
Katagiri A, Nakayama K, Rahman MT, Rahman M, Katagiri H, Nakayama N, Ishikawa M, Ishibashi T, Iida K, Kobayashi H, Otsuki Y, Nakayama S, Miyazaki K
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Journal Title
Mod Pathol.
Volume: 25
Pages: 282-288
Related Report
Peer Reviewed
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[Journal Article] Frequent loss of tumor suppressor ARID1A protein expression in adenocarcinomas/adenosquamous carcinomas of the uterine cervix.2012
Author(s)
Katagiri A, Nakayama K, Rahman MT, Rahman M, Katagiri H, Ishikawa M, Ishibashi T, Iida K, Otsuki Y, Nakayama S, Miyazaki K.
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Journal Title
Int J Gynecol Cancer.
Volume: 22
Pages: 208-212
Related Report
Peer Reviewed
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[Journal Article] EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target2011
Author(s)
Iida K, Nakayama K, Rahman MT, Rahman M, Ishikawa M, Katagiri A, Yeasmin S, Otsuki Y, Kobayashi H, Nakayama S, Miyazaki K
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Journal Title
Br J Cancer
Volume: 105
Pages: 420-427
Related Report
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[Journal Article] EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target.2011
Author(s)
Iida K, Nakayama K, Rahman MT, Rahman M, Ishikawa M, Katagiri A, Yeasmin S, Otsuki Y, Kobayashi H, Nakayama S, Miyazaki K.
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Journal Title
Br J Cancer.
Volume: 105
Pages: 420-427
Related Report
Peer Reviewed
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