Detection of mutagenic molecule for cervical cancer
Project/Area Number |
23592462
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Fujita Health University (2013) Keio University (2011-2012) |
Principal Investigator |
FUJII Takuma 藤田保健衛生大学, 医学部, 教授 (10218969)
|
Co-Investigator(Kenkyū-buntansha) |
OKUMA Hirokazu 東洋大学, 生命科学部, 教授 (30297733)
IWATA Takashi 慶應義塾大学, 医学部, 講師 (30296652)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ヒトパピローマウイルス / 子宮頸がん / 免疫応答 / ニオイセンサ / 子宮頸部腫瘍 / サイトカイン / パピローマウイルス / 細菌性腟症 |
Research Abstract |
The normal vaginal flora composed of both major lactobacillus and minor aerobic/anaerobic bacteria, keep the vaginal cleanliness. Overgrowth of the anaerobic bacteria or G. Vaginalis causes bacterial vaginosis. The multiple genotypes of HPV infection were observed under the overgrowth of anaerobic bacteria or G. Vaginalis, suggesting HPV infection and anaerobic bacteria or G. Vaginalis have network in premalignant status. HPV infection in the high grade of intraepithelial lesion results in the enhancement of immune response. This mechanism might have some negative effect on the progression. In contrast, HPV infections have an effect on the immune escape in the normal or low grade intraepithelial lesions. The balance of the viral infection and host immune response might be crucial for the multistep carcinogenesis in the cervix.
|
Report
(4 results)
Research Products
(63 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study2013
Author(s)
Fujii T, Takatsuka N, Nagata C, Matsumoto K, Oki A, Furuta R, Maeda H, Yasugi T, Kawana K, Mitsuhashi A, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
-
Journal Title
Int J Clin Oncol
Volume: 18
Pages: 1091-1101
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies2013
Author(s)
Nishio H, Fujii T, Sugiyama J, Kuji N, Tanaka M, Hamatani T, Miyakoshi K,Minegishi K, Tsuda H, Iwata T, Tanaka K, Fukuchi T, Takehara Y, Yoshimura Y, Aoki D
-
Journal Title
Hum Reprod
Volume: 28
Pages: 1793-1798
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Subsequent risks for cervical precancer and cancer in women with low-grade squamous intraepithelial lesions unconfirmed by colposcopy-directed biopsy:results from a multicenter, prospective, cohort study2012
Author(s)
Matsumoto K, Hirai Y, Furuta R, Takatsuka N, Oki A, Yasugi T, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
-
Journal Title
Int J Clin Oncol
Volume: 17
Pages: 233-239
DOI
Related Report
Peer Reviewed
-
[Journal Article] HLA Class II DRB1*1302 Allele Protects Against Progression to Cervical Intraepithelial neoplasia grade 32012
Author(s)
Matsumoto K, Hirai Y, Furuta R, Takatsuka N, Oki A, Yasugi T, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y,Kitagawa T, Yoshikawa H
-
Journal Title
Int J Gynecol Cancer
Volume: 22
Pages: 471-478
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated with Peutz-Jeghers syndrome due to a germline mutation of STK112012
Author(s)
Hirasawa A, Akahane T, Kobayashi Y, Masuda K, Banno K, Fujii T, Susumu N, Tsubo T, Kameyama K, Sugano K, Aoki D
-
Journal Title
Annals of Oncology
Volume: 23
Pages: 2990-2992
DOI
Related Report
Peer Reviewed
-
[Journal Article] Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study2012
Author(s)
Fujii T, Takatsuka N, Nagata C, Matsumoto K, Oki A, Furuta R, Maeda H, Yasugi T, Kawana K, Mitsuhashi A, Hirai Y, Iwasaka T, Yaegashi N, Watanabe y, Nagai Y, Kitagawa T, Yoshikawa H
-
Journal Title
Int J Clin Oncol
Volume: in press
Pages: in press
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Predicting the progression of cervival precursorlesions by human papillomavirus genotyping : A prospective cohort study2011
Author(s)
Matsumoto K, Oki A, Furuta R, Maeda H, Yasugi T, Takatsuka N, Mitsuhasi A, Fujii T, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
-
Journal Title
Int J Cancer
Volume: 128
Pages: 2898-2910
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Cartenoids,smoking and alcohol drinking affects outcome of low-grade CIN2011
Author(s)
T.Fujii, N.Takatsuka, K.Matsumoto, H.Maeda, T.Yasugi, A.Mitsuhashi, Y.Aoki, A.Oki, Y.Watanabe, H.Yoshikawa
Organizer
27th International Papillomavirus conference and clinical workshop
Place of Presentation
Berlin, Germany
Year and Date
September 17-22, 2011
Related Report
-
-
[Presentation] Cartenoids,smoking and alcohol drinking affects outcome of low-grade CIN2011
Author(s)
Fujii T, ,(et al 10,1^<st>) Takatsuka N, Matsumoto K, Maeda H, Yasugi T, Mitsuhashi A, Aoki Y, Oki A, Watanabe Y, Yoshikawa H
Organizer
27^<th> International Papillomavirus Conference and Clinical Workshop
Place of Presentation
Berlin, Germany
Year and Date
20110917-22
Related Report
-
-
-
-
-
-
-
-
-
-