Effect of microgravity on the gene expression in the mouse vestibular organ
| Project/Area Number |
23592478
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
USAMI Shin-ichi 信州大学, 医学部, 教授 (10184996)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Nobuyoshi 信州大学, 医学部, 助教 (20377641)
OGUCHI Tomohiro 信州大学, 医学部, 委嘱講師 (10377640)
NISHIO Shin-ya 信州大学, 医学部, 助教 (70467166)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 微小重力 / 前庭 / 神経可塑性 / 遺伝子 / 遺伝子発現 / 微少重力 / DNAマイクロアレイ |
|---|
| Research Abstract |
In the microgravity environment, significant decrease of vestibular inputs cause motion sickness. In this study, we compare the gene expression between 90 days space flight mouse and 15 days space flight mouse and its ground control mouse vestibular. As a result, Oc90, a major component of otoconia expression increased after 15 days space flight, but decreased after 90 days space flight. Similar situation were observed in the calcium binding protein S100a8 and S100a9. These results clearly indicated that the adaptation for micro gravity environment has acute adaptation phase and chronic adaptation phase.
|
Report
(4 results)
Research Products
(9 results)
