Development of a preventive drug for age-related deafness targeting neural crest-related genes

• Project/Area Number: 23592479
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nagoya University
• Principal Investigator: SONE MICHIHIKO 名古屋大学, 医学(系)研究科(研究院), 准教授 (30273238)
• Co-Investigator(Kenkyū-buntansha): OHGAMI Nobutaka 中部大学, 生命健康科学部, 准教授 (80424919)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 加齢性難聴 / 内耳 / ラセン神経節 / 神経堤細胞 / 難聴

Research Abstract

Preventive/cure methods for Waardenburg-Shah syndrome with congenital hearing loss has not developed yet due to congenital loss of intermediate cells (melanocytes) in inner ears. The congenital hearing loss involving neurodegeneration of spiral ganglion neurons (SGNs) in Ednrb(-/-)-mice were significantly restored by introducing an Ednrb transgene under control of the dopamine beta-hydroxylase promoter (DBH-EdnrB-Tg). The results of this study suggest Ednrb expressed in SGNs can be a novel target for a drug development of hearing losses. Meanwhile, the preventive effect of DBH-EdnrB-Tg expressed in SGNs on age-related deafness has been affected by genetic backgrounds. Further study will be needed to investigate the effect of DBH-EdnrB-Tg on age-related deafness.

Research Products

• [Journal Article] Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water (2014)
  • Author(s): Kumasaka MY, Yajima I, Ohgami N, Naito H, Omata Y, Kato M. Commentary to Krishna et al.
  • Journal Title: Arch Toxicol Volume: (In press)
• [Journal Article] Commentary to Krishna et al. (2014): Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water. (2014)
  • Author(s): Kumasaka MY, Yajima I, Ohgami N, Naito H, Omata Y, Kato M.
  • Journal Title: Arch Toxicol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity. (2014)
  • Author(s): Yajima I, Kumasaka MY, Yamanoshita O, Zou C, Li X, Ohgami N, Kato M.
  • Journal Title: Am J Cancer Res Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. (2014)
  • Author(s): Iida M, Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.
  • Journal Title: Eur J Dermatol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Enhanced Constitutive Invasion Activity in Human Nontumorigenic Keratinocytes Exposed to a Low Level of Barium for a Long Time. (2014)
  • Author(s): Thang ND, Yajima I, Ohnuma S, Ohgami N, Kumasaka YM, Ichihara G, Kato M.
  • Journal Title: Environmental Toxicology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Numerical assessment of cholesteatoma by signal intensity on non-EP-DWI and ADC maps. (2014)
  • Author(s): Suzuki H, Sone M, Yoshida T, Otake H, Kato K, TeranishiM, Suga K, Nakada T, Naganawa S, Nakashima T.
  • Journal Title: Otol Neurotol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Evaluation of vascular activity in otosclerosis by laser-Doppler flowmetry : comparison with CT densitometry (2013)
  • Author(s): Sone M, Yoshida T, Otake H, Kato K, Teranishi M, Naganawa S, Nakashima T
  • Journal Title: Otol Neurotol Volume: 34 Pages: 1559-1563
• [Journal Article] Endothelin-1 gene polymorphism in sudden sensorineural hearing loss (2013)
  • Author(s): Uchida Y, Teranishi M, Nishio N, Sugiura S, Hiramatsu M, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Ando F, Shimokata H, Nakashima T
  • Journal Title: Laryngoscope Volume: 123 Pages: 59-65
• [Journal Article] Establishment of Mouse Model of MYH9 Disorders : Heterozygous R702C Mutation Provokes Macrothrombocytopenia with Leukocyte Inclusion Bodies, Renal Glomerulosclerosis and Hearing Disability (2013)
  • Author(s): Suzuki N, Kunishima S, Ikejiri M, Maruyama S, Sone M, Takagi A, Ikawa M, Okabe M, Kojima T, Saito H, Naoe T, Matsushita T
  • Journal Title: PLos One Volume: 8
  • NAID: 120006957397
• [Journal Article] Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptorαin patients with Meniere's disease and sudden sensorineural hearing loss (2013)
  • Author(s): Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
  • Journal Title: Life Sci Volume: 92 Pages: 541-546
• [Journal Article] Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Meniere's disease in a Japanese population (2013)
  • Author(s): Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T
  • Journal Title: DNA Cell Biol Volume: 31 Pages: 1555-1562
• [Journal Article] Comparison of barium and arsenic concentrations in well drinking water and in human body samples and a novel remediation system for these elements in well drinking water. (2013)
  • Author(s): Kato M, Kumasaka YM, Ohnuma S, Furuta A, Kato Y, Shekhar HU, Kojima M, Koike Y, Thang ND, Ohgami N, Ly TB, Jia X, Yetti H, Naito H, Ichihara G, Yajima I.
  • Journal Title: PLoS ONE Volume: 8
  • Peer Reviewed
• [Journal Article] Establishing Normal Diameter Range of the Cochlear and Facial Nerves with 3D-CISS at 3T. (2013)
  • Author(s): Nakamichi R, Yamazaki M, Ikeda M, Isoda H, Kawai H, Sone M, Nakashima T, Naganawa S.
  • Journal Title: Magn Reson Med Sci Volume: 12 Pages: 241-247
  • NAID: 130003383918
  • Peer Reviewed
• [Journal Article] Evaluation of vascular activity in otosclerosis by laser-Doppler flowmetry: comparison with CT densitometry. (2013)
  • Author(s): Sone M, Yoshida T, Otake H, Kato K, Teranishi M, Naganawa S, Nakashima T.
  • Journal Title: Otol Neurotol Volume: 34 Pages: 1559-1563
  • Peer Reviewed
• [Journal Article] Endothelin-1 gene polymorphism in sudden sensorineural hearing loss. (2013)
  • Author(s): Uchida Y, Teranishi M, Nishio N, Sugiura S, Hiramatsu M, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Ando F, Shimokata H, Nakashima T.
  • Journal Title: Laryngoscope Volume: 123 Pages: 59-65
  • Peer Reviewed
• [Journal Article] Establishment of Mouse Model of MYH9 Disorders: Heterozygous R702C Mutation Provokes Macrothrombocytopenia with Leukocyte Inclusion Bodies, Renal Glomerulosclerosis and Hearing Disability. (2013)
  • Author(s): Suzuki N, Kunishima S, Ikejiri M, Maruyama S, Sone M, Takagi A, Ikawa M, Okabe M, Kojima T, Saito H, Naoe T, Matsushita T.
  • Journal Title: PLoS ONE Volume: 8
  • NAID: 120006957397
  • Peer Reviewed
• [Journal Article] Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Ménière’s disease. (2013)
  • Author(s): Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Suzuki M, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
  • Journal Title: Free Radic Res Volume: 47 Pages: 498-506
  • Peer Reviewed
• [Journal Article] Association Between Polymorphisms in Genes Encoding Methylenetetrahydrofolate Reductase and the Risk of Ménière's Disease. (2013)
  • Author(s): Huang Y, Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T
  • Journal Title: J Neurogenet Volume: 27 Pages: 5-10
  • Peer Reviewed
• [Journal Article] Endolymphatic Hydrops Revealed by Magnetic Resonance Imaging in Patients with Acute Low-Tone Sensorineural Hearing Loss. (2013)
  • Author(s): Shimono M, Teranishi M, Yoshida T, Kato M, Sano R, Otake H, Kato K, Sone M, Ohmiya N, Naganawa S, Nakashima T.
  • Journal Title: Otol Neurotol Volume: 34 Pages: 1241-1246
  • Peer Reviewed
• [Journal Article] olymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor α in patients with Ménière's disease and sudden sensorineural hearing loss. (2013)
  • Author(s): Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
  • Journal Title: Life Sci Volume: 93 Pages: 541-546
  • Peer Reviewed
• [Journal Article] Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study. (2013)
  • Author(s): Sone M, Kato T, Arao H, Izawa T, Suzuki Y, Ishida K, Nakashima T.
  • Journal Title: Acta Otolaryngol Volume: 133 Pages: 35-41
  • Peer Reviewed
• [Journal Article] Comparison of CT and MRI for evaluation of cholesteatoma with labyrinthine fistulae (2012)
  • Author(s): Sone M, Yoshida T, Naganawa S, Otake H, Kato K, Sano R, Teranishi M, Nakashima T
  • Journal Title: Laryngoscope Volume: 122 Pages: 1121-1125
• [Journal Article] Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes (2012)
  • Author(s): Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T
  • Journal Title: Gene Volume: 499 Pages: 226-230
• [Journal Article] c-Ret-mediated hearing losses (2012)
  • Author(s): Ohgami, N., Tamura, H., Ohgami, K., Iida, M., Yajima, I., Kumasaka, Y.M., Goto, Y., Sone, M., Nakashima, T., Kato, M
  • Journal Title: Int. J. Clin. Exp. Pathol Volume: 5 Pages: 23-28
• [Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice (2012)
  • Author(s): Ohgami, N., Ida-Eto, M., Sakashita, N., Sone, M., Nakashima, T., Tabuchi, K., Hoshino, T., Shimada, A., Tsuzuki, T., Yamamoto, M., Sobue, G., Jijiwa, M., Asai, N., Hara, A., Takahashi, M., Kato, M
  • Journal Title: Neurobiol. Aging Volume: 626 Pages: 25-34
• [Journal Article] Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice (2012)
  • Author(s): Tamura, H., Ohgami, N., Yajima, I., Iida, M., Ohgami, K., Fujii, N., Itabe, H., Kusudo, T., Yamashita, H., Kato, M
  • Journal Title: PLoS ONE Volume: 7
• [Journal Article] Hearing impairments caused by genetic and environmental factors (2012)
  • Author(s): Ohgami, N., Iida, M., Yajima, I., Tamura, H., Ohgami, K., Kato, M
  • Journal Title: Environmental Health and Preventive Medicine Volume: 18 Pages: 10-15
  • NAID: 10031143686
• [Journal Article] Exposure to low-dose barium by drinking water causes hearing loss in mice (2012)
  • Author(s): Ohgami, N., Hori, S., Ohgami, K., Tamura, H., Tsuzuki, T., Ohnuma, S., Kato, M
  • Journal Title: NeuroToxicology Volume: 33 Pages: 1276-1283
• [Journal Article] Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice. (2012)
  • Author(s): Tamura H
  • Journal Title: PLoS ONE Volume: 7
  • Peer Reviewed
• [Journal Article] Hearing impairments caused by genetic and environmental factors. (2012)
  • Author(s): Ohgami N
  • Journal Title: Environ Health Prev Med Volume: 18 Pages: 10-15
  • NAID: 10031143686
  • Peer Reviewed
• [Journal Article] Exposure to low-dose barium by drinking water causes hearing loss in mice. (2012)
  • Author(s): Ohgami N
  • Journal Title: NeuroToxicology Volume: 33 Pages: 1276-1283
  • Peer Reviewed
• [Journal Article] Functional analysis of GNG2 in human malignant melanoma cells. (2012)
  • Author(s): Yajima I
  • Journal Title: J Dermatol Sci Volume: 68 Pages: 172-178
  • Peer Reviewed
• [Journal Article] Comparison of CT and MRI for evaluation of cholesteatoma with labyrinthine fistulae. (2012)
  • Author(s): Sone M
  • Journal Title: Laryngoscope Volume: 112 Pages: 1121-1125
  • Peer Reviewed
• [Journal Article] Audiological signs in pediatric cases with dehiscence of the bony labyrinth caused by a high jugular bulb (2012)
  • Author(s): Sone M
  • Journal Title: Int J Pedia Otorhinolaryngol Volume: 76 Pages: 447-451
  • Peer Reviewed
• [Journal Article] Prevalence of laryngopharyngeal reflux symptoms: comparison between health check-up examinees and patients with otitis media. (2012)
  • Author(s): Sone M
  • Journal Title: Otolaryngol Head Neck Surg Volume: 146 Pages: 562-566
  • Peer Reviewed
• [Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice (2012)
  • Author(s): Ohgami N, Sone M, et al.
  • Journal Title: Neurobiology of Aging Volume: 印刷中
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing losses (2012)
  • Author(s): Ohgami N, Sone M, et al.
  • Journal Title: Int J Clin Exp Pathol Volume: 5 Pages: 23-28
  • Peer Reviewed
• [Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy (2012)
  • Author(s): Yajima I, Ohgami N, et al.
  • Journal Title: Dermatol Res Pract Volume: 2012 Pages: 354191-354191
  • Peer Reviewed
• [Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression (2012)
  • Author(s): Yajima I, Ohgami N, et al.
  • Journal Title: J Skin Cancer Volume: 印刷中
  • Peer Reviewed
• [Journal Article] A novel hairless mouse model for malignant melanoma (2012)
  • Author(s): Yajima I, Ohgami N, et al.
  • Journal Title: J Dermatol Sci Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Comparison of CT and MRI for evaluation of cholesteatoma with labyrinthine fistulae (2012)
  • Author(s): Sone M
  • Journal Title: Laryngoscope Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Morphological observation in the stria vascularis in midkine and pleiotrophin knockout mice (2011)
  • Author(s): Sone M, Yoshida T, Naganawa S, Otake H, Kato K, Sano R, Teranishi M, Nakashima T
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 41-45
• [Journal Article] Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing (2011)
  • Author(s): Ida-Eto, M., Ohgami, N., Iida, M., Yajima, I., Kumasaka, M.Y., Takaiwa, K., Kimitsuki, T., Sone, M., Nakashima, T., Tsuzuki, T., Komune, S., Yanagisawa, M., Kato, M
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 29621-29626
• [Journal Article] Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing (2011)
  • Author(s): da-Eto M, Ohgami N, Sone M, et al.
  • Journal Title: J Biol Chem Volume: 286 Pages: 29621-29626
  • Peer Reviewed
• [Presentation] 生活環境因子が誘発する神経変性疾患。 (2013)
  • Author(s): (4)大神信孝:
  • Organizer: 第8回Tokushima Young Investigators Conference (徳島大学医学研究科主催)
  • Year and Date: 2013-09-11
  • Invited
• [Presentation] 突発性難聴における酸化ストレス関連の遺伝子多型の検討 (2013)
  • Author(s): 寺西正明、内田育恵、加藤健、大竹宏直、吉田忠雄、杉浦彩子、曽根三千彦、中島務:
  • Organizer: 第58回日本聴覚医学会総会
  • Place of Presentation: 松本
• [Presentation] 腫診断における拡散強調画像の判定量的評価の有用性. (2013)
  • Author(s): 鈴木宏和、曽根三千彦、吉田忠雄、大竹宏直、加藤健、寺西正明、中島務:中耳真珠
  • Organizer: 第23回日本耳科学会総会
  • Place of Presentation: 宮崎
• [Presentation] Partial impairment of c-Ret accelerates age-related hearing loss (2013)
  • Author(s): 大神信孝、飯田真智子、加藤昌志
  • Organizer: 第36回日本神経科学大会/ Neuroscience2013()
  • Place of Presentation: 京都
• [Presentation] New Aspects on Pathophysiology and Imaging in Menieres Disease : Relationships between endolymphatic hydrops and symptoms. (2013)
  • Author(s): Sone M, Nakashima T, Yoshida T, Kato M, Teranishi M, Naganawa S
  • Organizer: The 20^<th> International Federation of Oto-Rhino-Laryngological Societies World Congress
  • Place of Presentation: Seoul, korea
• [Presentation] Evaluation of vascular activity in otosclerosis by laser-Doppler flowmetry: comparison with CT densitometry. (2013)
  • Author(s): Sone M
  • Organizer: American Academy of Otolaryngology-Head and Neck Surgery Foundation
  • Place of Presentation: Vancouver, Canada
• [Presentation] アブミ骨手術後の内耳障害とMRI評価 (2013)
  • Author(s): 曽根三千彦
  • Organizer: 第114回日本耳鼻咽喉科学会総会
  • Place of Presentation: ロイトン札幌 (札幌市)
• [Presentation] 飲水投与した低用量バリウムによる感音性難聴 (2013)
  • Author(s): 大神信孝
  • Organizer: 第24回日本微量元素学会学術集会
  • Place of Presentation: 関西大学（大阪府吹田市）
• [Presentation] Partial impairment of c-Ret accelerates age-related hearing loss (2013)
  • Author(s): 大神信孝
  • Organizer: 第36回日本神経科学大会 / Neuroscience2013
  • Place of Presentation: 国立京都国際会館 (京都市)
• [Presentation] 生活環境因子が誘発する神経変性疾患 (2013)
  • Author(s): 大神信孝
  • Organizer: 第８回Tokushima Young Investigators Conference
  • Place of Presentation: 徳島大学医学研究科 (徳島市)
  • Invited
• [Presentation] 飲水投与した低用量バリウムの組織分布の検討と聴覚系疾患への影響 (2013)
  • Author(s): 大神信孝
  • Organizer: フォーラム2013：衛生薬学・環境トキシコロジー
  • Place of Presentation: 九州大学・馬出キャンパス (福岡市)
• [Presentation] 飲水投与した低用量バリウムの聴覚系疾患への影響 (2013)
  • Author(s): 大神信孝
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学（金沢）
• [Presentation] 飲水投与した低用量バリウムの聴覚系への影響 (2013)
  • Author(s): 大神信孝
  • Organizer: 第133回日本薬学会年会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] 内耳障害を合併するP-ANCA陽性血管炎患者の3D-FLAIR MRI画像 (2012)
  • Author(s): 加藤健、曽根三千彦、寺西正明、大竹宏直、吉田忠雄、佐野塁、中島務
  • Organizer: 第113回日本耳鼻咽喉科学会総会
  • Place of Presentation: 新潟
• [Presentation] 耳鳴を主訴とする症例の3テスラMRIによる内リンパ水腫評価 (2012)
  • Author(s): 吉田忠雄、大竹宏直、加藤健、下野真理子、寺西正明、曽根三千彦、中島務.
  • Organizer: 第22回日本耳科学会総会
  • Place of Presentation: 名古屋
• [Presentation] Analysis of endothelin receptor B expressed in spiral ganglion neurons (2012)
  • Author(s): 大神信孝、飯田真智子、矢嶋伊知朗、加藤昌志:
  • Organizer: 第24回日本色素細胞学会学術大会
  • Place of Presentation: 長浜
• [Presentation] 中耳貯留液中の高ペプシノーゲンは感音難聴のリスクファクターか？ (2012)
  • Author(s): 曽根 三千彦
  • Organizer: 第113回日本耳鼻咽喉科学会総会
  • Place of Presentation: 朱鷺メッセ（新潟）
• [Presentation] Diagnosis and management of labyrinthine fistula (2012)
  • Author(s): Michihiko Sone
  • Organizer: The 9th International Conference on Cholesteatoma and Ear Surgery
  • Place of Presentation: 長崎ブリックホール（長崎）
• [Presentation] 3D FLAIR MRI所見を指標とした中耳真珠腫内耳瘻孔例の手術対応 (2012)
  • Author(s): 曽根 三千彦
  • Organizer: 第22回日本耳科学会総会
  • Place of Presentation: 名古屋国際会議場（名古屋）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2012)
  • Author(s): 大神信孝
  • Organizer: 132回日本薬学会年会
  • Place of Presentation: 北海道大学・札幌キャンパス（札幌）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2012)
  • Author(s): 大神信孝
  • Organizer: 第82回日本衛生学会総会（奨励賞受賞講演）(招待講演)
  • Place of Presentation: 京都大学・吉田キャンパス（京都）
• [Presentation] 低周波騒音が平衡感覚に与える影響の解析 (2012)
  • Author(s): 田村青鳥
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都大学・吉田キャンパス（京都）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 第84回日本生化学会大会・シンポジウム「D-アミノ酸の生化学:飛躍する新領域」
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] EDN1遺伝子Lys198Asn多型に関する突発性難聴ケースコントロール研究について (2011)
  • Author(s): 内田育恵,杉浦彩子,西尾直樹,多賀谷満彦、平松真理子、吉田忠雄,大竹宏直、加藤健、寺西正明、曽根三千彦,中島務
  • Organizer: 第112回日本耳鼻咽喉科学会総会
  • Place of Presentation: 京都
• [Presentation] 蝸牛神経核背側核電植の一例の聴覚能の検討 (2011)
  • Author(s): 棚橋汀路、松田直子、曽根三千彦
  • Organizer: 第56回日本聴覚医学会総会
  • Place of Presentation: 博多
• [Presentation] 内リンパ水腫症例における連続周波数ティンパノメトリーとMRI画像所見の比較 (2011)
  • Author(s): 加藤健、大竹宏直、吉田忠雄、寺西正明、曽根三千彦、朝日清光、中島務
  • Organizer: 第56回日本聴覚医学会総会
  • Place of Presentation: 博多
• [Presentation] 突発性難聴における炎症性サイトカインの遺伝子多型の検討 (2011)
  • Author(s): 寺西正明、内田育恵、西尾直樹、加藤健、大竹宏直、吉田忠雄、多賀谷満彦、鈴木宏和、曽根三千彦、杉浦彩子、中島務
  • Organizer: 第21回日本耳科学会総会
  • Place of Presentation: 沖縄
• [Presentation] メニエール病およびその周辺疾患における内リンパ腔MRI画像 (2011)
  • Author(s): 吉田忠雄、大竹宏直、加藤健、寺西正明、曽根三千彦、中島務.
  • Organizer: 第21回日本耳科学会総会
  • Place of Presentation: 沖縄
• [Presentation] Endothelin receptor B in spiral ganglion neurons partially contributes to postnatal development of hearing (2011)
  • Author(s): 大神信孝、飯田真智子、田村青鳥、加藤昌志
  • Organizer: 第35回日本神経科学大会/ Neuroscience2012
  • Place of Presentation: 名古屋
• [Presentation] Endothelin receptor B in spiral ganglion neurons partially contributes to postnatal development of hearing. (2011)
  • Author(s): 大神信孝
  • Organizer: 第35回日本神経科学大会 / Neuroscience2012
  • Place of Presentation: 名古屋国際会議場 (名古屋)
• [Presentation] Environmental stress-related diseases-Noise-induced physiological impairments- (2011)
  • Author(s): Ohgami N
  • Organizer: The 2nd International Symposium of Environmental Health Sciences in Malaysia.
  • Place of Presentation: University Malaysia Sabah,Malaysia
• [Presentation] 新規難聴遺伝子c-Retの解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 34回日本神経科学大会 / Neuroscience2011
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Dehiscence of the bony labyrinth caused by a high jugular bulb in children (2011)
  • Author(s): Sone M
  • Organizer: 28th Politzer Society Meeting
  • Place of Presentation: Athens, Greece
• [Presentation] Visualization of inner ear hydrops in a pendred syndrome mouse model by using microcomputed tomography (2011)
  • Author(s): Yoshida T, Sone M
  • Organizer: 28th Politzer Society Meeting
  • Place of Presentation: Athens, Greece
• [Presentation] 蝸牛神経核背側核電植の一例の聴覚能の検討 (2011)
  • Author(s): 棚橋汀路、曽根三千彦
  • Organizer: 第56回日本聴覚医学会総会
  • Place of Presentation: 福岡
• [Presentation] 内リンパ水腫症例における連続周波数ティンパノメトリーとMRI画像所見の比較 (2011)
  • Author(s): 加藤健、曽根三千彦
  • Organizer: 第56回日本聴覚医学会総会
  • Place of Presentation: 福岡
• [Presentation] メニエール病およびその周辺疾患における内リンパ腔MRI画像 (2011)
  • Author(s): 吉田忠雄、曽根三千彦
  • Organizer: 第２１回日本耳科学会総会
  • Place of Presentation: 宜野湾市
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 第84回日本生化学会大会・シンポジウム「D-アミノ酸の生化学:飛躍する新領域」
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] 騒音ストレスと関連する新規聴力制御遺伝子の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: フォーラム2011：衛生薬学・環境トキシコロジー
  • Place of Presentation: 金沢エクセル東急（金沢）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 4回「タンパク質の異常凝集とその防御・修復機構に関する研究会」
  • Place of Presentation: 京都大学原子炉実験所 （大阪）
• [Presentation] Environmental stress-related diseases-Noise-induced physiological impairments-.
  • Author(s): Ohgami N
  • Organizer: The 3rd International Symposium of Environmental Health Sciences in Hanoi, Vietnam
  • Place of Presentation: Hanoi University of Technology, Hanoi, Vietnam
  • Invited
• [Presentation] Analysis of molecular targets expressed in spiral ganglion neurons to prevent hearing losses.
  • Author(s): Ohgami N
  • Organizer: Department seminar at Dept. of Biochemistry, Dartmouth Medical School
  • Place of Presentation: Dartmouth Medical School, Hanover, NH, USA
  • Invited
• [Presentation] 低周波騒音が平衡感覚に与える影響
  • Author(s): 大神信孝
  • Organizer: フォーラム2012：衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋観光ホテル (名古屋)
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析
  • Author(s): 大神信孝
  • Organizer: 第5回「タンパク質の異常凝集とその防御・修復機構に関する研究会」
  • Place of Presentation: 京都大学原子炉実験所(大阪)
• [Presentation] Analysis of endothelin receptor B expressed in spiral ganglion neurons.
  • Author(s): 大神信孝
  • Organizer: 第24回日本色素細胞学会学術大会
  • Place of Presentation: 長浜バイオ大学（長浜）
• [Presentation] 低周波騒音曝露による平衡感覚異常の解析
  • Author(s): 大神信孝
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: つくばサイエンスインフォメーションセンター（筑波）
• [Book] Cholesteatoma and Ear Surgery-an update. Efficacy of 3D FLAIR MRI findings in evaluating cholesteatoma with labyrinthine fistulae (2013)
  • Author(s): Sone M, Yoshida T, Nakashima T. Cholesteatoma and Ear Surgery-an update. Efficacy of 3D FLAIR MRI findings in evaluating cholesteatoma with labyrinthine fistulae.
  • Publisher: Kugler Publications
• [Book] Efficacy of 3D FLAIR MRI findings in evaluating cholesteatoma with labyrinthine fistulae. Cholesteatoma and Ear Surgery-an update. (2013)
  • Author(s): Sone M, Yoshida T, Nakashima T.
  • Publisher: Kugler Publications
• [Book] ENTONI (2012)
  • Author(s): 曽根三千彦
  • Total Pages: 6
  • Publisher: 全日本病院出版会
• [Book] 今日の治療指針 (2011)
  • Author(s): 曽根三千彦
  • Total Pages: 1
  • Publisher: 医学書院
• [Book] 明日の臨床 (2011)
  • Author(s): 曽根三千彦
  • Total Pages: 7
  • Publisher: 愛知保険医協会
• [Patent(Industrial Property Rights)] 聴覚障害又は小脳性運動失調症の予防・治療剤 (2012)
  • Inventor(s): 大神信孝、加藤昌志
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-28
  • Overseas