| Project/Area Number |
23592484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SHIMOGORI Hiroaki 山口大学, 医学(系)研究科(研究院), 准教授 (70226273)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Keywords | 前庭神経系 / 抗うつ薬 / CREB / BDNF / trkB / 前庭眼反射 |
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| Research Abstract |
We investigated the effects of chronic application of antidepressant on the vestibular system in guinea pigs. In the hippocampal region, phosphorylated CREB-like immunoreactivities were observed, while, in the vestibular system, no immunoreactivities were found. We evaluated BDNF mRNA. In the hippocampal region, not in the vestibular system, BDNF mRNA level was statistically higher in the antidepressant group than that in the non-antidepressant group. Twenty-four hours after right lateral semicircular canal transection, we investigated BDNF and trkB mRNA in the vestibular system. In the vestibular ganglion cells, BDNF mRNA and trkB mRNA levels of the lesioned side in the antidepressant group were statistically higher than that of the intact side in the non-antidepressant group. In the vestibular nuclei, BDNF mRNA level of the lesioned side in the antidepressant group was statistically higher than that of the intact side in the non-antidepressant group.
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