The study of mechanism in the development, differentiation and regeneration of inner ear sensory cells

• Project/Area Number: 23592485
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kagawa University
• Principal Investigator: DONG YOUYI 香川大学, 医学部, 助教 (90457341)
• Co-Investigator(Kenkyū-buntansha): TOUKUDA Masaaki 香川大学, .医学部, 教授 (10163974) ; YAMAGUCHI Fuminori 香川大学, .医学部, 准教授 (40271085) ; KAMITORI Kazuyo 香川大学, 医学部, 助教 (40457338)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 内耳 / 発生学 / Inner ear / Development / Differentiation

Research Abstract

In this study we found that PTEN can be expressed in the differentiating marginal cells (MCs), root cells (RCs) and spiral ligament fibrocytes (SLFs). In the mature cochlea, PTEN lost its expression in MC and SLFs but it remains high expression in RCs. The expression pattern for PTEN suggests that it plays a critical role in the differentiation of the lateral wall.

Research Products

• [Journal Article] The expression of PTEN in the development of mouse cochlear lateral wall (2014)
  • Author(s): Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Noguchi C, Katagi A, Nishio M, Suzuki A, X Lou, Tokuda M
  • Journal Title: Neuroscience Volume: 258 Pages: 263-9
• [Journal Article] The expression of PTEN in the development of mouse cochlear lateral wall (2014)
  • Author(s): Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Noguchi C, Katagi A, Nishio M, Suzuki A, X Lou, Tokuda M.
  • Journal Title: Neuroscience Volume: 258 Pages: 263-269
  • Peer Reviewed
• [Presentation] The role of PTEN in the development of the interdental cells in mouse postnatal cochlea. (2013)
  • Author(s): 1. Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Noguchi C, Katagi M, Nishio M, Suzuki A, Tokuda M
  • Organizer: 86^<th> Biochemical conference of Japan, Yokohama
  • Place of Presentation: Japan,Yokohama
• [Presentation] PTEN regulates hair cell proliferation, differentiation and innervation in the mammalian inner ear (2013)
  • Author(s): Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Tokuda M.
  • Organizer: The 37^<th>Congress of the International Union of Physiological Sciences.
  • Place of Presentation: UK. Birmingham. .
• [Presentation] Role of PTEN in the development of inner ear (2013)
  • Author(s): Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Tokuda M
  • Organizer: The 90th Congress of Physiological Sciences
  • Place of Presentation: Tokyo
• [Presentation] Expression of PTEN in the development of inner ear (2013)
  • Author(s): Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Tokuda M
  • Organizer: The 89th Congress of Physiological Sciences.
  • Place of Presentation: Japan, Matsumoto
• [Presentation] PTEN regulates hair cell proliferation, differentiation and innervation in the mammalian inner ear. (2013)
  • Author(s): Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Tokuda M. PTEN regulates hair cell proliferation, differentiation and innervation in the mammalian inner ear.
  • Organizer: The 37thCongress of the International Union of Physiological Sciences
  • Place of Presentation: Birmingham.UK
• [Presentation] Role of PTEN in the development of inner ear (2013)
  • Author(s): Youyi Dong
  • Organizer: The 90th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo
• [Presentation] Role of PTEN in the development of auditory system (2012)
  • Author(s): Youyi Dong
  • Organizer: The 89th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Matsumoato, Nagano
• [Presentation] PTEN regulates the proliferation and differentiation of inner ear (2011)
  • Author(s): Youyi Dong
  • Organizer: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: Taipei, Taiwan
• [Remarks]
  • URL: http://www.kms.ac.jp/~physiol1/index.html