Relations with a film expression style of the prestin protein and the outer hair cell function
| Project/Area Number |
23592489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鍋倉 隆 宮崎大学, 医学部, 講師 (20301385)
長井 慎成 宮崎大学, 医学部, 助教 (70404457)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プレスチン / 細胞容積調節 / 細胞容積 |
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| Research Abstract |
The prestin specifically emerges at the outer hair cell in mammals, and it is revealed that it greatly participate in a hearing function.
In this study, 1.When we forcibly expressed the prestin on the cell, the ability of the cell volume regulation decreased. 2.When we administered the salicylic acid, which was the competing inhibitor of the prestin in regard to the volume-sensitive Cl- channel, to the cell, the channel current decreased in the cell forcibly expressed the prestin.
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Report
(4 results)
Research Products
(20 results)
