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Relations with a film expression style of the prestin protein and the outer hair cell function

Research Project

Project/Area Number 23592489
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of Miyazaki

Principal Investigator

MATSUDA Keiji  宮崎大学, 医学部, 准教授 (40253835)

Co-Investigator(Kenkyū-buntansha) 鍋倉 隆  宮崎大学, 医学部, 講師 (20301385)
長井 慎成  宮崎大学, 医学部, 助教 (70404457)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsプレスチン / 細胞容積調節 / 細胞容積
Research Abstract

The prestin specifically emerges at the outer hair cell in mammals, and it is revealed that it greatly participate in a hearing function.
In this study, 1.When we forcibly expressed the prestin on the cell, the ability of the cell volume regulation decreased. 2.When we administered the salicylic acid, which was the competing inhibitor of the prestin in regard to the volume-sensitive Cl- channel, to the cell, the channel current decreased in the cell forcibly expressed the prestin.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (11 results) Book (1 results)

  • [Journal Article] 開放乳突腔障害に対する皮膚・軟骨・有茎骨膜弁―体型の外耳道後壁再建型鼓室形成術(ブーツ様再建)2012

    • Author(s)
      松田圭二, 佐藤伸矢, 奥田 匠, 平原信哉, 直野秀和, 東野哲也
    • Journal Title

      Otol Japan

      Volume: 22 Pages: 23-30

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 伝音再建手術による骨導聴力への影響2012

    • Author(s)
      佐藤伸矢, 松田圭二, 河野浩万, 東野哲也
    • Journal Title

      Otol Japan

      Volume: 22 Pages: 131-136

    • NAID

      10030646710

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Propranololが著効した乳幼児耳下腺血管腫の1例2012

    • Author(s)
      平原信哉, 松田圭二, 外山勝浩, 永野由起, 長井慎成, 東野哲也
    • Journal Title

      日耳鼻

      Volume: 115 Pages: 632-635

    • NAID

      10030800051

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 混合難聴を伴った肥厚性硬膜炎の2症例2012

    • Author(s)
      福留真二, 鳥原康治, 平原信哉, 長井慎成, 東野哲也
    • Journal Title

      Otol Japan

      Volume: 22 Pages: 266-273

    • NAID

      10030959166

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 弛緩部型中耳真珠腫例における外耳道後壁破壊程度のCT評価2012

    • Author(s)
      後藤隆史, 東野哲也, 松田圭二
    • Journal Title

      Otol Japan

      Volume: 22 Pages: 814-819

    • NAID

      10031145234

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuro-otological findings in psychiatric patients with nystagmus.2011

    • Author(s)
      Kiyomizu K, Matsuda K, Torihara K, Nakayama M, Ishida Y , Yoshida K, Tono T
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 268 Pages: 1713-1719

    • Related Report
      2011 Research-status Report
  • [Journal Article] 弛緩部型真珠腫の進展度と術前後含気、術後聴力、再発率との関係2011

    • Author(s)
      松田圭二,河野浩万,長井慎成,外山勝浩,小玉隆男,東野哲也
    • Journal Title

      Otol Japan

      Volume: 21 Pages: 1-7

    • NAID

      10029699205

    • Related Report
      2011 Research-status Report
  • [Journal Article] 緊急気管切開術を要した喉頭真菌症の1例2011

    • Author(s)
      鍋倉隆,長井慎成,東野哲也
    • Journal Title

      喉頭

      Volume: 23 Pages: 36-39

    • NAID

      10030273696

    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞容積調節におけるプレスチンの及ぼす影響2013

    • Author(s)
      鍋倉隆, 松田圭二, 中村雄. 東野哲也
    • Organizer
      第23回日本耳科学会総会
    • Place of Presentation
      宮崎市
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞容積調節におけるプレスチンの及ぼす影響2013

    • Author(s)
      鍋倉 隆
    • Organizer
      第23回日本耳科学会
    • Place of Presentation
      宮崎県
    • Related Report
      2013 Annual Research Report
  • [Presentation] サイバーナイフによる治療効果の検討2012

    • Author(s)
      鍋倉 隆,外山勝浩,荻田幹夫,西井龍一,東野哲也
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] 鼓膜全面癒着を伴う緊張部型真珠腫に対する薄切軟骨を使用した鼓室形成術2012

    • Author(s)
      松田圭二,木原あゆみ,中村 雄,長井慎成,外山勝浩,東野哲也
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞容積調節におけるプレスチンの及ぼす影響2012

    • Author(s)
      鍋倉 隆,松田圭二,中村 雄,東野哲也
    • Organizer
      第22回日本耳科学会総会・学術講演会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 当科における後天性中耳真珠腫614例の進展度の検討2012

    • Author(s)
      松田圭二,鍋倉 隆,佐藤伸矢,井手慎介,東野哲也
    • Organizer
      第22回日本耳科学会総会・学術講演会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] Cochlear implantation in a patient with Epstein syndrome2011

    • Author(s)
      Nabekura T, Tono T
    • Organizer
      The 8th Asia Pacific symposium on Cochlear Implant and Related Sciences
    • Place of Presentation
      Daegu Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] 当科における反回神経麻痺の臨床統計2011

    • Author(s)
      長井慎成,鍋倉 隆,東野哲也
    • Organizer
      第23回日本喉頭科学会総会・学術講演会
    • Place of Presentation
      北海道旭川市
    • Related Report
      2011 Research-status Report
  • [Presentation] 一側性耳硬化症における臨床的特徴2011

    • Author(s)
      鍋倉 隆,東野哲也,松田圭二,土屋克之
    • Organizer
      第112回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      京都府京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 診断にMRIが有効であった第一鰓溝瘻孔の1例2011

    • Author(s)
      松田圭二,福留真二,外山勝浩,平原信哉,東野哲也
    • Organizer
      第73回耳鼻咽喉科臨床学会総会・学術講演会
    • Place of Presentation
      長野県松本市
    • Related Report
      2011 Research-status Report
  • [Presentation] Canal up型真珠腫手術における薄切耳介軟骨による再陥凹防止効果の検討2011

    • Author(s)
      松田圭二,外山勝浩,直野秀和,岩永英憲,植木義裕,東野哲也
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄県宜野湾市
    • Related Report
      2011 Research-status Report
  • [Book] 症例から見る難治性疾患の診断と治療 1.耳科領域編2011

    • Author(s)
      松田圭二,東野哲也
    • Total Pages
      16
    • Publisher
      国際医学出版
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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