| Project/Area Number |
23592492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IINO Yukiko 自治医科大学, 医学部, 教授 (30108534)
HIDAKA Hiroshi 東北大学大学院, 医学研究科, 講師 (40302103)
KANAZAWA Hiromi 自治医科大学, 医学部, 助教 (40570643)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 好酸球性中耳炎 / 抗IgE抗体 / 外リンパ灌流 |
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| Outline of Final Research Achievements |
To clarify the mechanism of the inner ear dysfunction due to the esosinophilic otitis media, IL-5, Eosinophil Cationic Protein(ECP)、eotaxin、leukotoruene（LT）and PAF were perfused through the perilymph by the precise peristaltic pump. By measuring the compound action potential(CAP) for a long period of time, the run down of the CAP was measured when the ECP was perfused. The anti IgE antibody is one of the important strategy for the sever bronchial asthma, which has the effectiveness of the eosinophilic otitis media was perfused through the perilymph. The results of no effect on the CAP by anti IgE perfusion represented the possibility for the newly therapeutic approach for the eosinophilic otitis media.
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