The molecular mechanism of mucosal hypertrophy by JNK in middle ear

• Project/Area Number: 23592497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Juntendo University
• Principal Investigator: FURUKAWA MASAYUKI 順天堂大学, 医学部, 准教授 (20359524)
• Co-Investigator(Kenkyū-buntansha): KUSUNOKI Takeshi 順天堂大学, 医学部, 准教授 (30248025) ; MATTUMOTO Fumihiko 順天堂大学, 医学部, 准教授 (70445584) ; KASAI Misato 順天堂大学, 医学部, 助教 (70549279)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 急性中耳炎 / JNK１ / 中耳粘膜肥厚 / JNK2 / 分子制御 / MAP kinase / 癒着性中耳炎 / 中耳炎 / JNK / DNA microarray / 細菌性中耳炎

Research Abstract

The irreversible hypertrophy of the middle ear mucosa was occurred in chronic otitis media and adhesive otitis media. The molecular mechanism of mucosal hypertrophy by JNK in middle ear was clarified