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Age-related olfactory dysfunction: cellular and molecular analyses

Research Project

Project/Area Number 23592506
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

KONDO Kenji  東京大学, 医学部附属病院, 講師 (40334370)

Co-Investigator(Renkei-kenkyūsha) YAMASOBA Tatsuya  東京大学, 医学部附属病院, 教授 (60251302)
SUZUKAWA Keigo  東京大学, 医学部附属病院, 助教 (50447398)
USHIO Munetak  東京大学, 医学部附属病院, 助教 (70361483)
KANAYA Kaori  東京大学, 医学部附属病院, 助教 (90456129)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords鼻科学 / 嗅覚障害 / 加齢変化 / カロリー制限 / エストロゲン / 感冒罹患後嗅覚障害 / FAT-1マウス / 嗅覚医学 / 嗅神経障害 / 神経再生 / 嗅覚 / 嗅神経上皮 / 再生
Research Abstract

1. Caloric restriction exacerbated the age-related neuroepithelial degeneration in the mouse olfactory mucosa and also worsened the regeneration of the olfactory neuroepithelium after injury. The downregulation of proliferative activity in neuroepithelium by caloric restriction appeared to play an important role in the pathogenesis. 2. The immune model of postviral olfactory disorder (PVOD) was developed in mice using Poly(I:C), a synthetic analog of viral double-stranded RNA. The analyses suggested that the secondary damage caused by the neutrophil-mediated innate immune response plays an important role in the pathogenesis of PVOD. 3. The analyses of estrogen receptor beta (ERbeta) -deficient mice suggested that estrogen plays a role in the homeostasis of the olfactory mucosa through ERbeta. 4. FAT-1 mice demonstrated better neuroepithelical regeneration after injury, suggesting that the tissue fatty acid is associated with the regeneration of the olfactory neuroepithelium.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (25 results) (of which Invited: 9 results) Remarks (3 results)

  • [Journal Article] Expression of IL-33 and its receptor ST2 in chronic rhinosinusitis with nasal polyp2014

    • Author(s)
      Baba S, Kondo K, Kanaya K, Suzukawa K, Ushio M, Urata S, Asakage T, Kakigi A, Suzukawa M, Ohta K, Yamasoba T.
    • Journal Title

      Laryngoscope

      Volume: 124 Issue: 4 Pages: 115-122

    • DOI

      10.1002/lary.24462

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes of the regeneration mode in the mouse peripheral olfactory system following olfactotoxic drug methimazole-induced damage2011

    • Author(s)
      Suzukawa K, Kondo K, Kanaya K, Sakamoto T, Watanabe K, Ushio M, Kaga K, Yamasoba T
    • Journal Title

      J Comp Neurol

      Volume: 519 Pages: 2154-2174

    • Related Report
      2013 Final Research Report
  • [Journal Article] Innate immune responses and neuroepithelial degeneration and regeneration in the mouse olfactory mucosa induced by intranasal administration of Poly(I : C)

    • Author(s)
      Kanaya K, Kondo K, Suzukawa K, Sakamoto T, Kikuta S, Okada K, Yamasoba T
    • Journal Title

      Cell Tissue Res

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] 嗅覚障害は治る:感冒後嗅覚障害(臨床シンポジウム)2013

    • Author(s)
      近藤健二
    • Organizer
      第52回日本鼻科学会学術講演会
    • Place of Presentation
      福井
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] メチマゾール障害後の嗅神経上皮の細胞増殖に対するカロリー制限の影響2013

    • Author(s)
      岩村均、近藤健二、坂本幸士、菊田周、鈴川佳吾、金谷佳織、山岨達也
    • Organizer
      第52回日本鼻科学会学術講演会
    • Place of Presentation
      福井
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Innate immune responses and neuroepithelial degeneration in the mouse olfactory mucosa induced by intranasal Poly(I : C).2013

    • Author(s)
      Kondo K, Kanaya K, Suzukawa K, Kikuta S, Sakamoto T, Yamasoba T
    • Organizer
      45th meeting of Korean Rhinologic Society
    • Place of Presentation
      Seoul
    • Year and Date
      2013-03-10
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Immune models of postviral olfactory disorder2013

    • Author(s)
      Kondo K, Kanaya K, Suzukawa K, Kikuta S, Sakamoto T, Yamasoba T
    • Organizer
      20th International Federation of Otorhinolaryngological Societies World Congress
    • Place of Presentation
      Seoul
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] Innate immune responses and neuroepithelial degeneration in the mouse olfactory mucosa induced by intranasal Poly(I : C)2013

    • Author(s)
      Kondo K, Kanaya K, Suzukawa K, Kikuta S, Sakamoto T, Yamasoba T
    • Organizer
      16th Asian Research Symposium in Rhinology
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 嗅覚障害は治る:感冒後嗅覚障害(臨床シンポジウム)2013

    • Author(s)
      近藤健二
    • Organizer
      第52回日本鼻科学会学術講演会
    • Place of Presentation
      福井
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] メチマゾール障害後の嗅神経上皮の細胞増殖に対するカロリー制限の影響.2013

    • Author(s)
      岩村均、近藤健二、坂本幸士、菊田周、鈴川佳吾、金谷佳織、山岨達也
    • Organizer
      第52回日本鼻科学会学術講演会
    • Place of Presentation
      福井
    • Related Report
      2013 Annual Research Report
  • [Presentation] Innate immune responses and neuroepithelial degeneration in the mouse olfactory mucosa induced by intranasal Poly(I:C)2013

    • Author(s)
      Kenji Kondo, Kaori Kanaya, Keigo Suzukawa, Shu Kikuta, Takashi Sakamoto, Tatsuya Yamasoba
    • Organizer
      16th Asian Research Symposium in Rhinology
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Immune responses and neuroepithelial degeneration induced by intranasal administration of Poly(I : C)in the mouse olfactory mucosa2012

    • Author(s)
      Kondo K, Kanaya K, Suzukawa K, Kikuta S, Sakamoto T, Yamasoba T
    • Organizer
      16th International Symposium on Olfaction and Taste
    • Place of Presentation
      Stockholm
    • Related Report
      2013 Final Research Report
  • [Presentation] Immune response, neuroepithelial degeneration and regeneration induced by intranasal administrationof Poly(I : C) in the mouse olfactory mucosa2012

    • Author(s)
      Kanaya K, Kondo K, Suzukawa K, Sakamoto T,Yamasoba T
    • Organizer
      24th Congress of the European Rhinologic Society & 31^<st> International Symposium of Infection & Allergy of the Nose
    • Place of Presentation
      Toulouse
    • Related Report
      2013 Final Research Report
  • [Presentation] 実験的カロリー制限はマウスにおいて加齢性の嗅粘膜変性を悪化させる2012

    • Author(s)
      近藤健二、鈴川佳吾、岩村均、菊田周、坂本幸士、金谷佳織、山岨達也
    • Organizer
      第51回日本鼻科学会学術講演会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Poly(I : C)経鼻投与により惹起される嗅上皮内好中球浸潤に対するアジスロマイシンの効果2012

    • Author(s)
      金谷佳織、近藤健二、鈴川佳吾、菊田周、坂本幸士、山岨達也
    • Organizer
      第51回日本鼻科学会学術講演会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Immune responses and neuroepithelial degeneration induced by intranasal administration of Poly(I:C) in the mouse olfactory mucosa.2012

    • Author(s)
      Kondo K, Kanaya K, Suzukawa K, Kikuta S, Sakamoto T, Yamasoba T.
    • Organizer
      16th International Symposium on Olfaction and Taste
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Research-status Report
  • [Presentation] Immune response, neuroepithelial degeneration and regeneration induced by intranasal administration of Poly(I:C) in the mouse olfactory mucosa.2012

    • Author(s)
      Kanaya K, Kondo K, Suzukawa K, Sakamoto T, Yamasoba T
    • Organizer
      24th Congress of the European Rhinologic Society & 31st International Symposium of Infection & Allergy of the Nose
    • Place of Presentation
      Toulouse, France
    • Related Report
      2012 Research-status Report
  • [Presentation] Poly(I:C)経鼻投与により惹起される嗅上皮内好中球浸潤に対するアジスロマイシンの効果2012

    • Author(s)
      金谷佳織、近藤健二、鈴川佳吾、菊田周、坂本幸士、山岨達也
    • Organizer
      第51回日本鼻科学会学術講演会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] 加齢に伴う嗅神経上皮の再生能低下の病態生理2011

    • Author(s)
      近藤健二、鈴川佳吾、山岨達也
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Age-related Changes of the Regeneration Mode in the Mouse Peripheral Olfactory System2011

    • Author(s)
      Kondo K
    • Organizer
      14th International Rhinologic Society and 30th International Symposium on Infection and Allergy of the Nose
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 加齢による嗅神経上皮の細胞動態の変化.2011

    • Author(s)
      近藤健二
    • Organizer
      日本味と匂い学会第45回大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] エストロゲン受容体β欠損マウスにみられる鼻腔病理所見2011

    • Author(s)
      近藤健二、鈴川佳吾、金谷佳織、坂本幸士、馬場信太郎、藤本千里、山岨達也
    • Organizer
      第50回日本鼻科学会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] Age-related Changes of the Regeneration Mode in the Mouse Peripheral Olfactory System.2011

    • Author(s)
      Kondo K
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kobe
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 加齢に伴う嗅神経上皮の再生能低下の病態生理

    • Author(s)
      近藤健二、鈴川佳吾、山岨達也
    • Organizer
      第11回日本抗加齢医学会総会(招待講演)
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Age-related Changes of the Regeneration Mode in the Mouse Peripheral Olfactory System

    • Author(s)
      Kenji Kondo
    • Organizer
      14th International Rhinologic Society and 30th International Symposium on Infection and Allergy of the Nose(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 加齢による嗅神経上皮の細胞動態の変化

    • Author(s)
      近藤健二
    • Organizer
      日本味と匂い学会第45回大会(招待講演)
    • Place of Presentation
      金沢
    • Related Report
      2011 Research-status Report
  • [Presentation] エストロゲン受容体β欠損マウスにみられる鼻腔病理所見

    • Author(s)
      近藤健二、鈴川佳吾、金谷佳織、 坂本幸士、馬場信太郎、 藤本千里、山岨達也
    • Organizer
      第50回日本鼻科学会
    • Place of Presentation
      岡山
    • Related Report
      2011 Research-status Report
  • [Presentation] Age-related Changes of the Regeneration Mode in the Mouse Peripheral Olfactory System

    • Author(s)
      Kenji Kondo
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery(招待講演)
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.h.u-tokyo.ac.jp/orl/

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京大学医学部耳鼻咽喉科学教室

    • URL

      http://www.h.u-tokyo.ac.jp/orl/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.h.u-tokyo.ac.jp/orl/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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