The effects of TGFalpha in intractable sinusitis and new treatment
| Project/Area Number |
23592508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Mie University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | TGFalpha / eosinophilic sinusitis / TGFα / MUC5AC / EGFシグナリング / 好酸球性副鼻腔炎 / IL-31 / Th2サイトカイン / ＴＧＦα / ＭＵＣ５ＡＣ |
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| Research Abstract |
Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease with thick mucus production, long-term nasal congestion, loss of sense of smell. In this study, we investigated which growth factor is deeply involved in the mucin overproduction in ECRS.
TGF-alpha immunoreactivity was found markedly increased in the submucosal tissue in the ECRS patient compared with that of a normal patient and with noneosinophilic CRS. TGF-alpha synergized with TNF-alpha to upregulate MUC5AC expression in human epithelial cells through the ERK signaling pathway.Our results demonstrated that TGF-alpha was highly expressed in the upper airway tract in ECRS patients and is deeply involved in mucus hypersecretion.
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Report
(4 results)
Research Products
(7 results)
