| Project/Area Number |
23592511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
OKANO Mitsuhiro 岡山大学, 医歯(薬)学総合研究科, 准教授 (60304359)
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| Co-Investigator(Kenkyū-buntansha) |
KARIYA Shin 岡山大学, 岡山大学病院, 助教 (10274226)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | サイトカイン / 副鼻腔炎 / 好酸球 / 黄色ﾌﾞﾄﾞｳ球菌 / 真菌 / プロテアーゼ / プロスタグラシン / 衛生仮説 / 黄色ブドウ球菌 / プロスタグランジン / 好酸球性副鼻腔炎 / TLR / 自然免疫 / 好酸球性鼻副鼻腔炎 |
|---|
| Research Abstract |
We sought to determine the extrinsic and intrinsic factors involving the pathogenesis of eosinophilic rhinosinusitis. We found that microbial components including exotoxins in Staphylococcus aureus, fungal antigens, TLR agonists and proteases regulates cytokine networks including IL-5, IL-13, IFN-gamma, IL-17A, IL-18, IL-33, IL-22 and IL-10, and involved in the pathogenesis of eosinophilic rhinosinusitis including nasal polyp formation, eosinophil infiltration into nasal polyps, radiological severity of rhinosinusitis, and lower airway obstruction.
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