| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Signaling pathways associated with the growth of cancer cell have been gradually revealed and the regulation of the pathway has been applied to treatment of various cancers. We identified the cluster of molecular which associated with the cross-talk of signaling pathway and epithelial-mesenchymal transition of head and neck cancer cells using the genome-proteome analysis. Furthermore, we find that the sensitivity to cetuximab, monoclonal antibody of epidermal growth factor receptor (EGFR), was correlated with the expression of EGFR itself and the level of ligands to EGFR. The regulation of the ligands might contributed to enhance the effect of cetuximab and expected to overcome the resistance to cetuximab
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